公开(公告)号：EP0831926A1

公开(公告)日：1998-04-01

申请号：EP96916251.0

申请日：1996-06-07

申请人： Marsden, John Christopher ,  NYCOMED IMAGING AS

发明人： DUGSTAD, Harald ,  KLAVENESS, Jo ,  RONGVED, Pal ,  SKURTVEIT, Roald

IPC分类号： A61K49

CPC分类号： A61K49/227

摘要： Diagnostic contrast agents having microbubbles of gas or a gas precursor stabilised by one or more membrane-forming lipids crosslinked or polymerised in the hydrophilic portion thereof may exhibit high degrees of stability and contrast efficacy.

公开(公告)号：EP0779821A1

公开(公告)日：1997-06-25

申请号：EP95930653.0

申请日：1995-09-06

申请人： Marsden, John Christopher ,  NYCOMED IMAGING AS

发明人： KLAVENESS, Jo ,  RONGVED, Pal ,  STRANDE, Per

IPC分类号： A61L15 ,  A61B8 ,  A61K49 ,  A61L27 ,  C08G63 ,  A61F2

CPC分类号： A61B8/481 ,  A61F2210/0004 ,  A61K49/0002 ,  A61K49/22 ,  A61L15/62 ,  A61L27/58

摘要： Contrast agents comprising gas-containing polymer microparticles and/or microballoons in which the polymer is a biodegradable polymer comprising repeating units of formula (II) (where a is an integer of 9-19 and b is an integer of 1-8) may be used in diagnostic applications such as ultrasound and MR imaging. The polymers are novel and are also claimed per se.

公开(公告)号：EP0620744B1

公开(公告)日：2000-04-12

申请号：EP93902156.4

申请日：1993-01-08

申请人： NYCOMED IMAGING AS

发明人： KLAVENESS, Jo ,  RONGVED, Pal ,  STUBBERUD, Lars

IPC分类号： A61K49/00

CPC分类号： A61K49/1818 ,  A61K49/1821 ,  A61K49/223 ,  A61K49/225

摘要： Contrast agents comprising microbubble-generating carbohydrate microparticles having a surfactant admixed within the microparticulate structure (with the proviso that the surfactant is not a saturated C10-20 fatty acid when the microparticulate carbohydrate is galactose) exhibit useful levels of contrast efficiency and/or stability and may be used in diagnostic applications such as ultrasound and MR imaging.

公开(公告)号：EP0752889A1

公开(公告)日：1997-01-15

申请号：EP95913223.0

申请日：1995-03-27

申请人： NYCOMED IMAGING AS ,  DAIICHI PHARMACEUTICAL CO., LTD.

发明人： KLAVENESS, Jo ,  BERG, Arne ,  JACOBSEN, Trond Vegard ,  RONGVED, Pal ,  EGE, Thorfinn ,  KIKUCHI, Hiroshi, Daiichi Pharmaceutical Co., Ltd. ,  YACHI, Kiyoto, Daiichi Pharmaceutical Co., Ltd.

IPC分类号： A61K49 ,  A61K51

CPC分类号： A61K49/227 ,  A61K49/0466 ,  A61K49/1812

摘要： The invention provides a diagnostic composition for administration to human or animal subjects the composition containing multilamellar liposomes, optionally together with unilamellar liposomes, the liposomes containing at least one imaging agent and being suspended in an aqueous medium containing said imaging agent, wherein the liposomes comprise a neutral phospholipid and a charged phospholipid, the average particle diameter of the liposomes is 50-3000 nm and the concentration of imaging agent in any aqueous phase filling the interior of the liposomes is substantially the same as that in the aqueous medium in which the liposomes are suspended. The contrast agents concerned are typically X-ray, MRI or ultrasound contrast agents.

摘要翻译： 本发明提供了用于给人或动物对象施用含有多层脂质体的组合物的组合物，所述组合物任选地与单层脂质体一起，所述脂质体含有至少一种显像剂并悬浮于含有所述显像剂的含水介质中，其中所述脂质体包含 中性磷脂和带电荷的磷脂，脂质体的平均粒径为50-3000nm，并且填充脂质体内部的任何水相中显像剂的浓度基本上与脂质体在其中的含水介质中的浓度相同 暂停。 有关的造影剂通常是X射线，MRI或超声造影剂。

公开(公告)号：EP0744960A1

公开(公告)日：1996-12-04

申请号：EP95908328.0

申请日：1995-02-15

申请人： NYCOMED IMAGING AS ,  HOLMES, Michael John

发明人： DUGSTAD, Harald ,  FOSS, Per, Antonius ,  KLAVENESS, Jo ,  RONGVED, Pal ,  SKURTVEIT, Roald ,  SOLBERG, Jan ,  AUKRUST, Inger, Reidun, Fjeldskaar

IPC分类号： A61K49

CPC分类号： A61K49/223

摘要： Microparticulate contrast agents comprising gas or a gas precursor encapsulated by a non-polymeric and non-polymerisable wall-forming material are readily characterisable materials exhibiting surprising structural integrity and stability.

公开(公告)号：EP0717658A1

公开(公告)日：1996-06-26

申请号：EP94925549.0

申请日：1994-09-05

申请人： NYCOMED IMAGING AS

发明人： DUGSTAD, Harald ,  FOSS, Per, Antonius ,  KLAVENESS, Jo ,  REDFORD, Keith ,  RONGVED, Pal ,  SKURTVEIT, Roald

IPC分类号： A61K49 ,  B01F17 ,  B01J13 ,  C08G63

CPC分类号： B01F17/0028 ,  A61K49/223 ,  Y10T428/2985

摘要： Polymer-based gas-containing contrast agents in which microbubbles of gas are encapsulated by non-polymerisable wall-forming block or graft copolymer surfactants. The polymer surfactants are preferably biodegradable and include block and graft copolymers containing linkages of formula (I): -(O)m-CO-O-C(R1R2)-O-CO-(O)¿n?- (where R?1 and R2¿ each represent a hydrogen atom or a carbon-attached monovalent organic group or R?1 and R2¿ together form a carbon-attached divalent organic group and m and n are each zero or 1) which are themselves novel.

公开(公告)号：EP0620744A1

公开(公告)日：1994-10-26

申请号：EP93902156.0

申请日：1993-01-08

申请人： HOLMES, Michael John ,  NYCOMED IMAGING AS

发明人： KLAVENESS, Jo ,  RONGVED, Pal ,  STUBBERUD, Lars

IPC分类号： A61K49

CPC分类号： A61K49/1818 ,  A61K49/1821 ,  A61K49/223 ,  A61K49/225

摘要： Agents de contraste comportant des microparticules glucidiques aptes à générer des microbulles et dotées d'un tensio-actif mélangé à l'intérieur de la structure microparticulaire (à condition que le tensio-actif ne soit pas un acide gras C10-20 saturé lorsque le glucide microparticulaire est la galactose), présentant une efficacité de contraste et/ou une stabilité précieuse(s), et pouvant s'utiliser dans les applications diagnostiques telles que l'imagerie par ultrasons et par résonance magnétique.

公开(公告)号：EP0752889B1

公开(公告)日：2002-06-26

申请号：EP95913223.4

申请日：1995-03-27

申请人： Nycomed Imaging AS ,  DAIICHI PHARMACEUTICAL CO., LTD.

发明人： KLAVENESS, Jo ,  BERG, Arne ,  JACOBSEN, Trond Vegard ,  RONGVED, Pal ,  EGE, Thorfinn ,  KIKUCHI, Hiroshi, Daiichi Pharmaceutical Co., Ltd. ,  YACHI, Kiyoto, Daiichi Pharmaceutical Co., Ltd.

IPC分类号： A61K49/00 ,  A61K49/04

CPC分类号： A61K49/227 ,  A61K49/0466 ,  A61K49/1812

摘要： The invention provides a diagnostic composition for administration to human or animal subjects the composition containing multilamellar liposomes, optionally together with unilamellar liposomes, the liposomes containing at least one imaging agent and being suspended in an aqueous medium containing said imaging agent, wherein the liposomes comprise a neutral phospholipid and a charged phospholipid, the average particle diameter of the liposomes is 50-3000 nm and the concentration of imaging agent in any aqueous phase filling the interior of the liposomes is substantially the same as that in the aqueous medium in which the liposomes are suspended. The contrast agents concerned are typically X-ray, MRI or ultrasound contrast agents.

公开(公告)号：EP0779821B1

公开(公告)日：2002-03-27

申请号：EP95930653.1

申请日：1995-09-06

申请人： NYCOMED IMAGING AS

发明人： KLAVENESS, Jo ,  RONGVED, Pal ,  STRANDE, Per

IPC分类号： A61K49/00 ,  A61M31/00 ,  A61F2/30 ,  A61K9/00

CPC分类号： A61B8/481 ,  A61F2210/0004 ,  A61K49/0002 ,  A61K49/22 ,  A61L15/62 ,  A61L27/58

公开(公告)号：EP0620743B1

公开(公告)日：1998-07-22

申请号：EP93902155.6

申请日：1993-01-08

申请人： NYCOMED IMAGING AS

发明人： KLAVENESS, Jo ,  RONGVED, Pal ,  STUBBERUD, Lars

IPC分类号： A61K49/00

CPC分类号： A61K49/223 ,  A61K49/226

摘要： Contrast agents comprising microbubble-generating carbohydrate microparticles in admixture with an amphiphilic organic acid containing in excess of 20 carbon atoms exhibit good stability and/or enhanced contrast effect and may be used in diagnostic applications such as ultrasound and MR imaging.

摘要翻译： 造影剂微泡包含产生的混合物的碳水化合物微粒与含有过量20个碳原子的两亲性有机酸表现出良好的稳定性和/或增强的对比度的效果，并且可以在诊断应用中，例如超声和MR成像中使用。