公开(公告)号：EP0744960A1

公开(公告)日：1996-12-04

申请号：EP95908328.0

申请日：1995-02-15

申请人： NYCOMED IMAGING AS ,  HOLMES, Michael John

发明人： DUGSTAD, Harald ,  FOSS, Per, Antonius ,  KLAVENESS, Jo ,  RONGVED, Pal ,  SKURTVEIT, Roald ,  SOLBERG, Jan ,  AUKRUST, Inger, Reidun, Fjeldskaar

IPC分类号： A61K49

CPC分类号： A61K49/223

摘要： Microparticulate contrast agents comprising gas or a gas precursor encapsulated by a non-polymeric and non-polymerisable wall-forming material are readily characterisable materials exhibiting surprising structural integrity and stability.

公开(公告)号：EP0689462A1

公开(公告)日：1996-01-03

申请号：EP94909227.0

申请日：1994-03-16

申请人： HOLMES, Michael John ,  NYCOMED IMAGING AS

发明人： AABYE, Arne ,  BERG, Arne ,  DUGSTAD, Harald ,  DYVIK, Kari ,  FOSS, Per, Antonius ,  KLAVENESS, Jo ,  OSTENSEN, Jonny ,  RONGVED, P l ,  STRANDE, Per ,  TOLLESHAUG, Helge

IPC分类号： A61K49

CPC分类号： A61K49/227 ,  A61K49/223

摘要： Microparticulate materials which are capable of chemical generation of gas after formulation with an appropriate carrier liquid, e.g. water for injection, and/or after administration to a subject, e.g. as a result of exposure to blood or other body fluids, may be used as contrast agents in diagnostic imaging, particularly ultrasound and magnetic resonance imaging.

公开(公告)号：EP0689461A1

公开(公告)日：1996-01-03

申请号：EP94909226.0

申请日：1994-03-16

申请人： HOLMES, Michael John ,  NYCOMED IMAGING AS

发明人： BERG, Arne ,  DUGSTAD, Harald ,  FOSS, Per, Antonius ,  KLAVENESS, Jo ,  OSTENSEN, Jonny ,  RONGVED, Pal ,  STRANDE, Per

IPC分类号： A61K9 ,  A61K49

CPC分类号： A61K49/226 ,  A61K49/223

摘要： Oil-in-water emulsions in which the oil phase comprises condensed or dissolved oil-soluble gas/fluid or gas precursor are useful as ultrasound contrast agents. Such products contain insignificant amounts of free gas bubbles or microbubbles in their stored form and exhibit good storage stability, but may be designed to promote rapid microbubble generation immediately before or upon administration.

摘要翻译： 其中油相包含冷凝或溶解的油溶性气体/流体或气体前体的水包油乳液可用作超声造影剂。 这些产品在其储存的形式中含有微不足道的游离气泡或微泡，并且表现出良好的储存稳定性，但可以设计为在施用之前或之后立即促进快速微泡产生。

公开(公告)号：EP0717658A1

公开(公告)日：1996-06-26

申请号：EP94925549.0

申请日：1994-09-05

申请人： NYCOMED IMAGING AS

发明人： DUGSTAD, Harald ,  FOSS, Per, Antonius ,  KLAVENESS, Jo ,  REDFORD, Keith ,  RONGVED, Pal ,  SKURTVEIT, Roald

IPC分类号： A61K49 ,  B01F17 ,  B01J13 ,  C08G63

CPC分类号： B01F17/0028 ,  A61K49/223 ,  Y10T428/2985

摘要： Polymer-based gas-containing contrast agents in which microbubbles of gas are encapsulated by non-polymerisable wall-forming block or graft copolymer surfactants. The polymer surfactants are preferably biodegradable and include block and graft copolymers containing linkages of formula (I): -(O)m-CO-O-C(R1R2)-O-CO-(O)¿n?- (where R?1 and R2¿ each represent a hydrogen atom or a carbon-attached monovalent organic group or R?1 and R2¿ together form a carbon-attached divalent organic group and m and n are each zero or 1) which are themselves novel.

公开(公告)号：EP0831926A1

公开(公告)日：1998-04-01

申请号：EP96916251.0

申请日：1996-06-07

申请人： Marsden, John Christopher ,  NYCOMED IMAGING AS

发明人： DUGSTAD, Harald ,  KLAVENESS, Jo ,  RONGVED, Pal ,  SKURTVEIT, Roald

IPC分类号： A61K49

CPC分类号： A61K49/227

摘要： Diagnostic contrast agents having microbubbles of gas or a gas precursor stabilised by one or more membrane-forming lipids crosslinked or polymerised in the hydrophilic portion thereof may exhibit high degrees of stability and contrast efficacy.

公开(公告)号：EP0782564A1

公开(公告)日：1997-07-09

申请号：EP95932109.0

申请日：1995-09-22

申请人： NYCOMED IMAGING AS

发明人： ALMEN, Torsten ,  ANDERSSON, Sven ,  WISTRAND, Lars-Göran ,  GOLMAN, Klaes ,  ANTONSEN, Oyvind ,  FOSSHEIM, Rune ,  WIGGEN, Unni, Nordby ,  WIKSTRÖM, Häkan, Medicinal Chemistry unit ,  KLINGSTEDT, Tomas ,  LEUNBACH, Ib ,  BERG, Arne ,  DUGSTAD, Harald

IPC分类号： A61K49 ,  C07C33 ,  C07C43 ,  C07C49 ,  C07C69 ,  C07C233 ,  C07C235 ,  C07C237 ,  C07C275 ,  C07C307 ,  C07C311 ,  C07C317

CPC分类号： C07C33/46 ,  A61K49/0433 ,  C07C33/483 ,  C07C235/16 ,  C07C237/46

摘要： The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula (I), wherein n is 0 or 1, and where n is 1 each C6R5 moiety may be the same or different; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M1, two or three non-adjacent R groups in each C6R5 moiety being iodine and at least one, and preferably two or three, R groups in each C6R5 moiety being M or M1 moieties; X denotes a bond or a group providing a 1 to 7 atom chain linking two C6R5 moieties or, where n is 0, X denotes a group R; each M independently is a non-ionic hydrophilic moiety; and each M1 independently represents a C1-4alkyl group substituted by at least one hydroxyl group and optionally linked to the phenyl ring via a carbonyl, sulphone or sulphoxide group, at least one R group being an M1 moiety; with the proviso that where n is zero either at least one M1 group other than a hydroxymethyl or 1,2-dihydroxyethyl group is present or then if one hydroxymethyl or 1,2-dihydroxyethyl M1 group is present at least one nitrogen-attached or hydroxylated-C3-4 alkyl moiety-containing M group is also present and isomers thereof.

公开(公告)号：EP0689461B1

公开(公告)日：2000-07-05

申请号：EP94909226.6

申请日：1994-03-16

申请人： NYCOMED IMAGING AS

发明人： BERG, Arne ,  DUGSTAD, Harald ,  FOSS, Per, Antonius ,  KLAVENESS, Jo ,  OSTENSEN, Jonny ,  RONGVED, Pal ,  STRANDE, Per

IPC分类号： A61K49/00

CPC分类号： A61K49/226 ,  A61K49/223

公开(公告)号：EP0521977B1

公开(公告)日：1996-09-11

申请号：EP91906843.7

申请日：1991-03-27

申请人： NYCOMED IMAGING AS

发明人： BERG, Arne ,  ALMEN, Torsten ,  KRAUTWURST, Klaus, Dieter ,  KIM, Sook-Hui ,  RONGVED, Pal ,  KLAVENESS, Jo ,  DUGSTAD, Harald

IPC分类号： A61K49/04 ,  A61K49/00

CPC分类号： C07F11/005 ,  A61K49/04 ,  A61K51/02 ,  A61K51/04 ,  A61K51/0482 ,  A61K2123/00 ,  Y10S514/836

摘要： The invention relates to the use as contrast enhancing agents in medical imaging, especially X-ray imaging, of multinuclear complexes, i.e. complexes, such as those of W2O2(ν2O)2, in which the complexed entity comprises at least two contrast enhancing atoms.

公开(公告)号：EP0452392B1

公开(公告)日：1995-04-12

申请号：EP90901813.7

申请日：1990-01-15

申请人： NYCOMED IMAGING AS

发明人： ALMEN, Torsten ,  BERG, Arne ,  DUGSTAD, Harald ,  KLAVENESS, Jo ,  KRAUTWURST, Klaus, Dieter ,  RONGVED, Pal

IPC分类号： C07D211/46 ,  A61K49/00 ,  C07D265/30 ,  C07D207/12 ,  C07D241/04 ,  C07D279/12 ,  A61K51/00 ,  A61K49/04

CPC分类号： C07D211/56 ,  A61K47/54 ,  A61K47/547 ,  A61K49/06 ,  A61K51/0478 ,  A61K51/0482 ,  A61K2121/00 ,  A61K2123/00 ,  C07D207/14 ,  C07D241/04 ,  C07D265/30 ,  C07D279/12 ,  C07F3/003 ,  C07F5/003 ,  C07F9/94 ,  C07F13/005 ,  Y10S514/836 ,  Y10T436/24

摘要： There are provided heterocyclic chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents being compounds of formula (I) (wherein X represents a bond, an oxygen or sulphur atom or a group of formula CHR?1 or NR3¿; each R1 which may be the same or different represents a hydrogen atom, a group of formula OR?3 or NR3R3¿ or an alkyl or alkoxyalkyl group optionally substituted by a hydroxyl group or by a group of formula NR3R3 or CONR3R3; each R2 which may be the same or different represents a hydrogen atom or an alkyl or alkoxy group optionally substituted by a hydroxyl or alkoxy group; each R3 which may be the same or different represents a hydrogen atom, an optionally hydroxylated alkyl group or a group of formula CH¿2?Y; Y represents a group of formula COZ, CON(OH)R?4, POZ¿2 or SO2Z; Z represents a group of formula OR?4, Nr4R4¿ or (II) where each R11 which may be the same or different is a hydrogen atom, a hydroxyl group or an optionally hydroxylated alkyl group, s is 0, 1 or 2, and W is a group CHR?11, NR11¿ or an oxygen atom; and each R4 which may be the same or different represents a hydrogen atom or an optionally mono- or poly hydroxylated alkyl, alkoxyalkyl or polyalkoxyalkyl group; with the provisos that where s is 0 then W is a CHR11 group and that where X represents a bond or a group CHR1 at least one group R1 or R2 represents other than a hydrogen atom or an unsubstituted alkyl group) and chelate complexes and salts thereof.

公开(公告)号：EP0521977A1

公开(公告)日：1993-01-13

申请号：EP91906843.0

申请日：1991-03-27

申请人： NYCOMED IMAGING AS

发明人： BERG, Arne ,  ALMEN, Torsten ,  KRAUTWURST, Klaus, Dieter ,  KIM, Sook-Hui ,  RONGVED, Pal ,  KLAVENESS, Jo ,  DUGSTAD, Harald

IPC分类号： A61K ,  A61K49 ,  A61K51 ,  C07F11

CPC分类号： C07F11/005 ,  A61K49/04 ,  A61K51/02 ,  A61K51/04 ,  A61K51/0482 ,  A61K2123/00 ,  Y10S514/836

摘要： L'invention concerne l'utilisation, comme agents d'amélioration du contraste en imagerie médicale, notamment en radiographie, de complexes multinucléaires, c'est-à-dire de complexes tels que ceux de formule W2O2(mu2O)2, dans lesquels l'entité composite comprend au moins deux atomes améliorant le contraste.

摘要翻译： 本发明涉及多核配合物的医学成像尤其是放射线照相术中的对比增强剂，即配合物如式W 2 O 2（mu 2 O）2的配合物，其中 复合实体包括至少两个对比增强原子。