公开(公告)号：EP0963209A2

公开(公告)日：1999-12-15

申请号：EP97910518.0

申请日：1997-10-28

申请人： Marsden, John Christopher ,  NYCOMED IMAGING AS

发明人： KLAVENESS, Jo ,  RONGVED, P l ,  H GSET, Anders ,  TOLLESHAUG, Helge ,  GODAL, Aslak ,  CUTHBERTSON, Alan ,  L VHAUG, Dagfinn ,  SOLBAKKEN, Magne

IPC分类号： A61K47 ,  A61K49 ,  A61K51

CPC分类号： A61K49/0058 ,  A61K47/542 ,  A61K47/62 ,  A61K47/6925 ,  A61K49/0043 ,  A61K49/0091 ,  A61K49/223 ,  A61K51/0497 ,  A61K51/088

摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generated material, in which the reporter is coupled or linked to one or more non-bioactive vectors.

公开(公告)号：EP0689462A1

公开(公告)日：1996-01-03

申请号：EP94909227.0

申请日：1994-03-16

申请人： HOLMES, Michael John ,  NYCOMED IMAGING AS

发明人： AABYE, Arne ,  BERG, Arne ,  DUGSTAD, Harald ,  DYVIK, Kari ,  FOSS, Per, Antonius ,  KLAVENESS, Jo ,  OSTENSEN, Jonny ,  RONGVED, P l ,  STRANDE, Per ,  TOLLESHAUG, Helge

IPC分类号： A61K49

CPC分类号： A61K49/227 ,  A61K49/223

摘要： Microparticulate materials which are capable of chemical generation of gas after formulation with an appropriate carrier liquid, e.g. water for injection, and/or after administration to a subject, e.g. as a result of exposure to blood or other body fluids, may be used as contrast agents in diagnostic imaging, particularly ultrasound and magnetic resonance imaging.