公开(公告)号：EP3766516A1

公开(公告)日：2021-01-20

申请号：EP19201980.0

申请日：2014-03-14

申请人： President and Fellows of Harvard College ,  Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： STARY, Georg ,  RADOVIC-MORENO, Aleksandar Filip ,  BASTO, Pamela A. ,  STARNBACH, Michael N. ,  LANGER, Robert ,  FAROKHZAD, Omid C. ,  ANDRIAN, Ulrich Von

IPC分类号： A61K39/118 ,  A61K45/00 ,  A01N63/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P33/00 ,  A61P37/04

摘要： Provided herein are new compositions including an inactivated pathogen and one or more adjuvant loaded polymeric nanoparticles, wherein the adjuvant-loaded nanoparticles are bound to the inactivated pathogen. These compositions are useful for preventing and/or treating diseases caused by the specific pathogens, especially when administered to a subject's mucosal membranes.

公开(公告)号：EP2723324A1

公开(公告)日：2014-04-30

申请号：EP12731268.4

申请日：2012-06-21

申请人： Massachusetts Institute Of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： LIPPARD, Stephen, J. ,  PARK, Ga Young ,  JOHNSTONE, Timothy ,  FAROKHZAD, Omid C. ,  GADDE, Suresh

IPC分类号： A61K9/51 ,  C07F15/00 ,  A61K33/24 ,  A61P35/00

CPC分类号： C07F15/0093

摘要： The present invention relates to compositions, kits, and methods for treatment of cancers. In some cases, the composition comprises a platinum compound comprising a phenanthridine ligand.

公开(公告)号：EP2618821A2

公开(公告)日：2013-07-31

申请号：EP11827647.6

申请日：2011-09-23

申请人： The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： KARP, Jeffrey M. ,  VEMULA, Praveen Kumar ,  CAMPBELL, Nathaniel R. ,  SYED, Abdullah M. ,  ZHANG, Sufeng ,  FAROKHZAD, Omid C. ,  LANGER, Robert S.

IPC分类号： A61K9/48 ,  A61K9/22 ,  A61K9/20 ,  A61K9/06 ,  A61K47/30 ,  A61K31/166 ,  A61K31/16 ,  A61P35/00

CPC分类号： A61K47/22 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/1075 ,  A61K31/166 ,  A61K31/405 ,  A61K31/4188 ,  A61K31/4745 ,  A61K31/573 ,  A61K31/58 ,  A61K31/713 ,  A61K38/28 ,  A61K47/14 ,  A61K47/26 ,  A61K47/28

摘要： Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

摘要翻译： 描述了自组装凝胶组合物，其包括胶凝剂，例如分子量为2500以下的酶切口凝胶剂。 自组装凝胶组合物可以包封一种或多种试剂。 还描述了使用自组装凝胶组合物制备自组装凝胶组合物的方法和药物递送方法。

公开(公告)号：EP3894561A1

公开(公告)日：2021-10-20

申请号：EP19897160.8

申请日：2019-12-11

申请人： The Brigham and Women's Hospital, Inc.

发明人： FAROKHZAD, Omid C. ,  KONG, Na ,  SHI, Jinjun ,  TAO, Wei

IPC分类号： C12N15/113 ,  C07K16/28 ,  A61K9/14 ,  A61K51/04

公开(公告)号：EP2512522A2

公开(公告)日：2012-10-24

申请号：EP10842613.1

申请日：2010-12-16

申请人： Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： FAROKHZAD, Omid C. ,  KOLISHETTI, Nagesh ,  DHAR, Shanta ,  LIPPARD, Stephen J. ,  LANGER, Robert S. ,  VALENCIA, Pedro, M.

IPC分类号： A61K47/48 ,  A61K47/30 ,  A61K9/22 ,  A61K9/20 ,  A61P35/00 ,  A61P25/28

CPC分类号： A61K45/06 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6937

摘要： Delivery compositions are provided that include two or more active agents, wherein at least one active agent is conjugated to a polymer. The delivery compositions allow for controlled release of multiple active agents, including active agents with varying solubility, charge, and/or molecular weight.