公开(公告)号：EP3189134A1

公开(公告)日：2017-07-12

申请号：EP15778076.8

申请日：2015-09-03

申请人： The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： KARP, Jeffrey M. ,  LANGER, Robert S. ,  YIN, Xiaolei ,  JOSHI, Nitin

IPC分类号： C12N5/0793 ,  A61K35/12

CPC分类号： C12N5/062 ,  A61K35/36 ,  C12N2501/415 ,  C12N2501/42

摘要： Method and compositions for inducing the self-renewal of stem/progenitor supporting cells comprised by a cochlear cell population, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.

摘要翻译： 用于诱导耳蜗细胞群包含的干/祖细胞支持细胞的自我更新的方法和组合物，包括诱导干/祖细胞增殖，同时在子细胞中维持分化为毛细胞的能力。

公开(公告)号：EP3004221A1

公开(公告)日：2016-04-13

申请号：EP14732750.6

申请日：2014-05-23

申请人： Massachusetts Institute of Technology ,  The Children's Medical Center Corporation ,  The Brigham and Women's Hospital, Inc.

发明人： KARP, Jeffrey M. ,  DEL NIDO, Pedro ,  LANG, Nora ,  LANGER, Robert S. ,  PEREIRA, Maria Jose M.N. ,  LEE, Yuhan

IPC分类号： C08J3/24 ,  C08L67/06 ,  A61L24/04 ,  A61L15/22 ,  A61L15/58

CPC分类号： A61L24/046 ,  A61L15/26 ,  A61L15/42 ,  A61L15/58 ,  A61L24/001 ,  A61L2400/18 ,  C08F2222/1073 ,  C08G63/47 ,  C08G63/914 ,  C08L67/04

摘要： Pre-polymers for use as tissue sealants and adhesives, and methods of making and using thereof are provided. The pre-polymers have flow characteristics such that they can be applied through a syringe or catheter but are sufficiently viscous to remain in place at the site of application and not run off the tissue. The pre-polymers are also sufficiently hydrophobic to resist washout by bodily fluids. The pre-polymers are stable in bodily fluids; that is the pre-polymer does not spontaneously crosslink in bodily fluids absent the presence of an intentionally applied stimulus to initiate crosslinking. Upon crosslinking, the adhesive exhibits significant adhesive strength in the presence of blood and other bodily fluids. The adhesive is sufficiently elastic that it is able to resist movement of the underlying tissue. The adhesive can provide a hemostatic seal. The adhesive is biodegradable and biocompatible, causing minimal inflammatory response.

摘要翻译： 提供用作组织密封剂和粘合剂的预聚物，及其制备和使用方法。 预聚物具有流动特性，使得它们可以通过注射器或导管施用，但足够粘稠以在施用部位保持就位，而不会从组织中流出。 预聚物也足够疏水以抵抗身体液体的冲洗。 预聚物在体液中是稳定的; 也就是预聚物在体液中不会自发交联，而不存在有意施加的刺激以引发交联。 交联时，粘合剂在存在血液和其他体液时显示出显着的粘合强度。 粘合剂具有足够的弹性，使得其能够抵抗下面的组织的运动。 粘合剂可以提供止血密封。 粘合剂是可生物降解和生物相容的，导致最小的炎症反应。

公开(公告)号：EP2858614A1

公开(公告)日：2015-04-15

申请号：EP13800636.6

申请日：2013-06-06

申请人： The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： LAULICHT, Bryan ,  KARP, Jeffrey M. ,  LANGER, Robert S.

IPC分类号： A61F13/02

CPC分类号： A61F13/024 ,  A61F13/0246 ,  A61F13/025 ,  A61F13/0253 ,  A61F13/0256 ,  A61F13/0259 ,  A61F13/0269 ,  A61F2013/00412 ,  A61F2013/00676 ,  A61F2013/00685 ,  A61F2013/00702 ,  A61F2013/0071 ,  A61F2013/00748 ,  A61F2013/008 ,  A61F2013/00804 ,  A61F2013/00838 ,  A61F2013/15569 ,  B29C65/5021 ,  B32B37/26 ,  B32B38/10 ,  B32B2037/268 ,  C09J7/255 ,  C09J2205/302 ,  C09J2467/006 ,  Y10T428/24851 ,  Y10T428/2839

摘要： Methods and compositions for securing to and removing adhesive tapes from substrates, e.g., delicate substrates such as skin, are described. The methods include providing an adhesive tape comprising an adhesive layer and a support layer in contact with the adhesive layer. A first adhesion level between the adhesive layer and the support layer is, or can be controlled to be, less than a second adhesion level between the adhesive layer and the substrate. The methods further include applying the adhesive tape to the substrate by contacting the adhesive layer to the substrate while the support layer remains in contact with the adhesive layer; and removing the support layer from the substrate by separating the support layer from the adhesive layer.

公开(公告)号：EP2618821A2

公开(公告)日：2013-07-31

申请号：EP11827647.6

申请日：2011-09-23

申请人： The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： KARP, Jeffrey M. ,  VEMULA, Praveen Kumar ,  CAMPBELL, Nathaniel R. ,  SYED, Abdullah M. ,  ZHANG, Sufeng ,  FAROKHZAD, Omid C. ,  LANGER, Robert S.

IPC分类号： A61K9/48 ,  A61K9/22 ,  A61K9/20 ,  A61K9/06 ,  A61K47/30 ,  A61K31/166 ,  A61K31/16 ,  A61P35/00

CPC分类号： A61K47/22 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/1075 ,  A61K31/166 ,  A61K31/405 ,  A61K31/4188 ,  A61K31/4745 ,  A61K31/573 ,  A61K31/58 ,  A61K31/713 ,  A61K38/28 ,  A61K47/14 ,  A61K47/26 ,  A61K47/28

摘要： Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

摘要翻译： 描述了自组装凝胶组合物，其包括胶凝剂，例如分子量为2500以下的酶切口凝胶剂。 自组装凝胶组合物可以包封一种或多种试剂。 还描述了使用自组装凝胶组合物制备自组装凝胶组合物的方法和药物递送方法。

公开(公告)号：EP3416593A1

公开(公告)日：2018-12-26

申请号：EP17753844.4

申请日：2017-02-16

申请人： Children's Medical Center Corporation ,  The Brigham and Women's Hospital, Inc.

发明人： FEINS, Eric N. ,  DEL NIDO, Pedro J. ,  VASILYEV, Nikolay V. ,  YAMAUCHI, Haruo ,  PERRIN, Douglas P. ,  HAMMER, Peter ,  ARABAGI, Veaceslav ,  KARP, Jeffrey M. ,  LEE, Yuhan ,  O'CEARBHAILL, Eoin D.

IPC分类号： A61F2/28 ,  A61F2/24 ,  A61F2/00 ,  A61L27/50 ,  A61L27/58 ,  A61L27/14 ,  A61L27/04 ,  A61F2/30

CPC分类号： A61L27/58 ,  A61F2/2445 ,  A61F2/2846 ,  A61F2250/0007 ,  A61F2250/0082 ,  A61L27/04 ,  A61L27/14 ,  A61L27/50

摘要： An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the outer element.

公开(公告)号：EP2488164A2

公开(公告)日：2012-08-22

申请号：EP10824174.6

申请日：2010-10-15

申请人： The Brigham and Women's Hospital, Inc.

发明人： KARP, Jeffrey M. ,  SARKAR, Debanjan ,  VEMULA, Praveen Kumar

IPC分类号： A61K9/22 ,  A61K9/20 ,  A61K47/30 ,  A61K35/12 ,  A61K49/00 ,  A61P35/00 ,  A61P25/28 ,  A61P19/10

CPC分类号： A61K47/6937 ,  A61K31/573 ,  A61K31/704 ,  A61K35/28 ,  A61K38/1816 ,  A61K47/6921 ,  A61K47/6935 ,  C12N5/0662

摘要： A composition includes an isolated cell; at least one particle within said cell; and at least one active agent associated with the particle, wherein the active agent is capable of being released from the cell. A method includes administration of such a cell to a subject.

公开(公告)号：EP4125963A1

公开(公告)日：2023-02-08

申请号：EP21781695.8

申请日：2021-04-02

申请人： The Brigham and Women's Hospital, Inc.

发明人： KARP, Jeffrey M. ,  YANG, Kisuk ,  HAMILOS, Allison E. ,  O'CEARBHAILL, Eoin ,  JONES, Peter Anthony

IPC分类号： A61K35/39 ,  A61F2/02 ,  A61K9/00 ,  A61K35/12

公开(公告)号：EP3352738A1

公开(公告)日：2018-08-01

申请号：EP16849871.5

申请日：2016-09-26

申请人： The Brigham and Women's Hospital, Inc.

发明人： KARP, Jeffrey M. ,  LEE, Yuhan ,  TAVAKKOLI, Ali ,  DEELMAN, Tarawatie E.

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K9/10 ,  A61K9/107 ,  A61K9/14 ,  A61K31/715 ,  A61K31/737

CPC分类号： A61K31/737 ,  A61K9/0053 ,  A61K9/107 ,  A61K31/7024 ,  A61K31/721 ,  A61K47/36 ,  A61K47/38

摘要： This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.