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公开(公告)号：EP2751127B1
公开(公告)日：2016-07-27
申请号：EP12751509.6
申请日：2012-08-29
发明人： FISCHER, Gunter , MALESEVIC, Miroslav , ERDMANN, Frank , KÜHLING, Jan , BUKRINSKY, Michael , CONSTANT, Stephanie , RÜHTER, Gerd , NUSSBAUMER, Peter , DINKEL, Klaus
CPC分类号： C07K7/645 , C12N9/90 , C12Y502/01008
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公开(公告)号：EP2751127A1
公开(公告)日：2014-07-09
申请号：EP12751509.6
申请日：2012-08-29
发明人： FISCHER, Gunter , MALESEVIC, Miroslav , ERDMANN, Frank , KÜHLING, Jan , BUKRINSKY, Michael , CONSTANT, Stephanie , RÜHTER, Gerd , NUSSBAUMER, Peter , DINKEL, Klaus
CPC分类号： C07K7/645 , C12N9/90 , C12Y502/01008
摘要： The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in medicine, more particularly in the treatment/diagnosis of acute and chronic inflammatory diseases, viral infections, cancer, degenerative muscle diseases, neurodegenerative diseases and damage that is associated with calcium homeostasis impairment. The novel cyclosporin derivatives additionally have no immunosuppressive effect.
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公开(公告)号：EP4367103A1
公开(公告)日：2024-05-15
申请号：EP22744729.9
申请日：2022-07-07
发明人： DILUCREZIA, Raffaella , BRÖNSTRUP, Mark , BILITEWSKI, Ursula , DEGENHART, Carsten , DINKEL, Klaus , JERYE, Karoline , KALAWY FANSA, Eyad , KOROTKOV, Vadim , MEDINA, Eva , ROX, Katharina , SHEKHAR, Aditya , WEICH, Herbert
IPC分类号： C07D241/44 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D515/04 , A61K31/4985 , A61P31/04
CPC分类号： C07D241/44 , C07D401/12 , C07D409/12 , C07D403/12 , C07D405/12 , C07D515/04 , A61P31/04
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公开(公告)号：EP4301736A1
公开(公告)日：2024-01-10
申请号：EP22797303.9
申请日：2022-09-25
发明人： KOCH, Uwe , ZISCHINSKY, Gunther , UNGER, Anke , NUSSBAUMER, Peter , KLEBL, Bert , CHOIDAS, Axel , DINKEL, Klaus , ENGEL, Julian , DEGENHART, Carsten , HUBER, Robert , NAM, Kiyean , KIM, Jaeseung , SEO, Jeongjea , LEE, Seung-Joo , JEON, Yeejin , AHN, Wongyun
IPC分类号： C07D273/00 , A61P35/00 , A61K31/33 , C07D491/08
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