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公开(公告)号：EP2751127B1
公开(公告)日：2016-07-27
申请号：EP12751509.6
申请日：2012-08-29
发明人： FISCHER, Gunter , MALESEVIC, Miroslav , ERDMANN, Frank , KÜHLING, Jan , BUKRINSKY, Michael , CONSTANT, Stephanie , RÜHTER, Gerd , NUSSBAUMER, Peter , DINKEL, Klaus
CPC分类号： C07K7/645 , C12N9/90 , C12Y502/01008
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公开(公告)号：EP2751127A1
公开(公告)日：2014-07-09
申请号：EP12751509.6
申请日：2012-08-29
发明人： FISCHER, Gunter , MALESEVIC, Miroslav , ERDMANN, Frank , KÜHLING, Jan , BUKRINSKY, Michael , CONSTANT, Stephanie , RÜHTER, Gerd , NUSSBAUMER, Peter , DINKEL, Klaus
CPC分类号： C07K7/645 , C12N9/90 , C12Y502/01008
摘要： The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in medicine, more particularly in the treatment/diagnosis of acute and chronic inflammatory diseases, viral infections, cancer, degenerative muscle diseases, neurodegenerative diseases and damage that is associated with calcium homeostasis impairment. The novel cyclosporin derivatives additionally have no immunosuppressive effect.
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公开(公告)号：EP2680852A1
公开(公告)日：2014-01-08
申请号：EP12706839.3
申请日：2012-03-01
IPC分类号： A61K31/53 , A61K31/5355 , C07D251/48 , C07D403/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , A61P31/14 , A61P31/16 , A61P31/22 , A61P33/02 , A61P33/10 , A61P33/12 , A61P31/04
CPC分类号： A61K31/5377 , A61K31/53 , A61K31/5355 , A61K45/06 , C07D251/48 , C07D401/04 , C07D403/04 , C07D403/14 , C07D413/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , A61K2300/00
摘要： The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted triazine derivatives as inhibitors for a protein kinase.
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公开(公告)号：EP2550257B1
公开(公告)日：2016-12-21
申请号：EP11711039.5
申请日：2011-03-20
发明人： EICKHOFF, Jan , NUSSBAUMER, Peter , RÜHTER, Gerd , SCHULTZ-FADEMRECHT, Carsten , LÜCKING, Ulrich , CHOIDAS, Axel , KLEBL, Bert
IPC分类号： C07D251/22 , C07D401/04 , C07D403/12 , C07D407/04 , A61K31/53 , A61P35/00 , A61P37/00 , C07D401/12
CPC分类号： C07D251/16 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D251/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/10 , C07D407/04 , C07D413/10
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公开(公告)号：EP2681193B1
公开(公告)日：2016-01-06
申请号：EP12706263.6
申请日：2012-03-01
发明人： RÜHTER, Gerd , NUSSBAUMER, Peter , CHOIDAS, Axel , SCHULTZ-FADEMRECHT, Carsten , KLEBL, Bert , EICKHOFF, Jan
IPC分类号： C07D213/74 , A61K31/44 , A61P35/00
CPC分类号： C07D213/74 , A61K31/4418 , A61K45/06
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公开(公告)号：EP2681193A1
公开(公告)日：2014-01-08
申请号：EP12706263.6
申请日：2012-03-01
发明人： RÜHTER, Gerd , NUSSBAUMER, Peter , CHOIDAS, Axel , SCHULTZ-FADEMRECHT, Carsten , KLEBL, Bert , EICKHOFF, Jan
IPC分类号： C07D213/74 , A61K31/44 , A61P35/00
CPC分类号： C07D213/74 , A61K31/4418 , A61K45/06
摘要： The present invention relates to disubstituted pyridine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted pyridine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted pyridine derivatives as inhibitors for a protein kinase.
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公开(公告)号：EP2550257A1
公开(公告)日：2013-01-30
申请号：EP11711039.5
申请日：2011-03-20
发明人： EICKHOFF, Jan , NUSSBAUMER, Peter , RÜHTER, Gerd , SCHULTZ-FADEMRECHT, Carsten , LÜCKING, Ulrich , CHOIDAS, Axel , KLEBL, Bert
IPC分类号： C07D251/22 , C07D401/04 , C07D403/12 , C07D407/04 , A61K31/53 , A61P35/00 , A61P37/00 , C07D401/12
CPC分类号： C07D251/16 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D251/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/10 , C07D407/04 , C07D413/10
摘要： The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted triazine derivatives as inhibitors for a protein kinase. formula (I) wherein R
1 is formula (II), formula (III) or formula (IV).摘要翻译： 本发明涉及二取代的三嗪衍生物和/或其药学上可接受的盐，这些衍生物作为药物活性剂的用途，特别是用于预防和/或治疗感染性疾病，包括机会性疾病，免疫疾病，自身免疫性疾病，心血管疾病 ，细胞增殖性疾病，炎症，勃起功能障碍和中风，以及含有所述二取代的三嗪衍生物和/或其药学上可接受的盐中的至少一种的药物组合物。 此外，本发明涉及所述二取代三嗪衍生物作为蛋白激酶的抑制剂的用途。
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