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公开(公告)号：EP2751127B1
公开(公告)日：2016-07-27
申请号：EP12751509.6
申请日：2012-08-29
发明人： FISCHER, Gunter , MALESEVIC, Miroslav , ERDMANN, Frank , KÜHLING, Jan , BUKRINSKY, Michael , CONSTANT, Stephanie , RÜHTER, Gerd , NUSSBAUMER, Peter , DINKEL, Klaus
CPC分类号： C07K7/645 , C12N9/90 , C12Y502/01008
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公开(公告)号：EP2370106A2
公开(公告)日：2011-10-05
申请号：EP09774835.4
申请日：2009-12-04
发明人： FISCHER, Gunter , MALESEVIC, Miroslav , ERDMANN, Frank , KÜHLING, Jan , BUKRINSKY, Michael , CONSTANT, Stephanie
CPC分类号： A61K49/0017 , A61K47/64 , A61K47/645 , A61K47/6455
摘要： The invention relates to an active ingredient-peptide construct for extracellular enrichment, to a method for enriching active ingredients in an extracellular space of a multicellular object, to the use of the active ingredient-peptide construct according to the invention for producing a pharmaceutical, and to a pharmaceutical composition comprising the active ingredient-peptide construct according to the invention.
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公开(公告)号：EP2751127A1
公开(公告)日：2014-07-09
申请号：EP12751509.6
申请日：2012-08-29
发明人： FISCHER, Gunter , MALESEVIC, Miroslav , ERDMANN, Frank , KÜHLING, Jan , BUKRINSKY, Michael , CONSTANT, Stephanie , RÜHTER, Gerd , NUSSBAUMER, Peter , DINKEL, Klaus
CPC分类号： C07K7/645 , C12N9/90 , C12Y502/01008
摘要： The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in medicine, more particularly in the treatment/diagnosis of acute and chronic inflammatory diseases, viral infections, cancer, degenerative muscle diseases, neurodegenerative diseases and damage that is associated with calcium homeostasis impairment. The novel cyclosporin derivatives additionally have no immunosuppressive effect.
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