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公开(公告)号：EP2751127B1
公开(公告)日：2016-07-27
申请号：EP12751509.6
申请日：2012-08-29
发明人： FISCHER, Gunter , MALESEVIC, Miroslav , ERDMANN, Frank , KÜHLING, Jan , BUKRINSKY, Michael , CONSTANT, Stephanie , RÜHTER, Gerd , NUSSBAUMER, Peter , DINKEL, Klaus
CPC分类号： C07K7/645 , C12N9/90 , C12Y502/01008
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公开(公告)号：EP2751127A1
公开(公告)日：2014-07-09
申请号：EP12751509.6
申请日：2012-08-29
发明人： FISCHER, Gunter , MALESEVIC, Miroslav , ERDMANN, Frank , KÜHLING, Jan , BUKRINSKY, Michael , CONSTANT, Stephanie , RÜHTER, Gerd , NUSSBAUMER, Peter , DINKEL, Klaus
CPC分类号： C07K7/645 , C12N9/90 , C12Y502/01008
摘要： The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in medicine, more particularly in the treatment/diagnosis of acute and chronic inflammatory diseases, viral infections, cancer, degenerative muscle diseases, neurodegenerative diseases and damage that is associated with calcium homeostasis impairment. The novel cyclosporin derivatives additionally have no immunosuppressive effect.
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3.发明公开VERFAHREN ZUR IDENTIFIZIERUNG UND HERSTELLUNG VON EFFEKTOREN CALMODULIN-ABH NGIGER PEPTIDYL-PROLYL CIS/TRANS ISOMERASEN 审中-公开方法鉴定和生产EFFECTORS钙调蛋白ABH NGIGER肽脯氨酰顺/反异构酶
公开(公告)号：EP1706504A1
公开(公告)日：2006-10-04
申请号：EP05706982.5
申请日：2005-01-24
IPC分类号： C12Q1/533
CPC分类号： C12Q1/533 , G01N2333/4727 , G01N2500/02
摘要： The invention relates to a method for identifying and producing effectors of peptidyl-prolyl cis/trans isomerases which can be activated by calmodulin. The invention also relates to the use of the identified effectors for the production of medicaments, and to screening methods and kits.
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4.发明授权
公开(公告)号：EP1421106B1
公开(公告)日：2009-01-21
申请号：EP02796249.7
申请日：2002-08-20
摘要： The invention is based on the finding that the cis/trans isomerisation of secondary amide peptide bonds in oligo- and poly-peptides can be catalytically promoted. Said catalysis is furthermore brought about by enzymes called secondary amide peptide bond cis/trans isomerases (APIases). It can be assumed that the APIase activity plays a central role in a number of pathophysiological processes. The invention thus relates to medicaments, comprising substances which inhibit APIase activity.
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5.发明公开USE OF CERTAIN CHEMICAL COMPOUNDS FOR THE INHIBITION OF THE PEPTIDYL-PROLYL CIS/TRANS ISOMERASE ACTIVITY OF CYCLOPHILINS 审中-公开某些化合物用于抑制肽基脯氨酰顺亲环/反异构酶活性使用
公开(公告)号：EP2056806A2
公开(公告)日：2009-05-13
申请号：EP07786683.8
申请日：2007-08-14
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , Heinrich-Heine-Universität Düsseldorf
发明人： FISCHER, Gunter , SCHIENE-FISCHER, Cordelia , DAUM, Sebastian , KÜLLERTZ, Gerhard , BRAUN, Manfred , FEAUX DE LACROIX, Boris
IPC分类号： A61K31/12 , A61K31/136 , A61K31/343 , A61P37/02 , A61P31/00 , A61P33/00 , A61P17/06 , A61P35/00 , A61P31/04 , A61P31/12 , A61P31/10 , A61P19/02 , A61P25/28 , A61P25/16 , A61P25/00 , A61P3/10 , A61P9/00 , A61P13/00
CPC分类号： A61K31/12 , A61K31/136 , A61K31/343 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/471 , Y02A50/475 , Y02A50/481 , Y02A50/483
摘要： The present invention relates to the use of certain spiro, ketone and carboxylic acid compounds for the inhibition of the peptidyl-prolyl cis/trans isomerase activity of cyclophilins and the use of these compounds for the production of a cosmetic or pharmaceutical composition for the promotion of hair growth or for the treatment or prevention of inflammatory autoimmune diseases, of diseases caused by fungi, of bacterial infections, of viral infections, of diseases caused by parasites, protozoa or worms, of cancer, of diseases of cells, of fibrosing diseases, and of non-neoplastic changes and diseases which are attributable to prions and changes in the structure and function of cellular proteins and cells.
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6.发明公开VORRICHTUNG UND VERFAHREN ZUR ANALYSE VON WECHSELWIRKUNGEN ZWISCHEN BIOMOLEKÜLEN 审中-公开设备和方法分析之间的相互作用生物分子
公开(公告)号：EP1766402A2
公开(公告)日：2007-03-28
申请号：EP05857270.2
申请日：2005-07-07
IPC分类号： G01N33/543
CPC分类号： C40B30/04 , G01N33/54353
摘要： The invention relates to a device for the analysis of interactions between biomolecules, comprising a support on which a number of biomolecules are immobilised on the surface of the support material in a regular or irregular arrangement, by means of linkers, whereby two biomolecules are bonded to each linker. The invention further relates to a method for detection of interactions between biopolymers immobilised on a surface, comprising the steps of preparation of a device, according to one of the above claims, setting a defined separation between two biopolymers, immobilised on the surface and the measuring of a signal, generated by the interaction between the two biopolymers.
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7.发明授权INHIBITORS OF PHOSPHOSERINE AND PHOSPHOTHREONINE-PROLINE-SPECIFIC ISOMERASES 有权磷酸盐和磷酸肌酸脯氨酸特异性异构体的抑制剂
公开(公告)号：EP1012178B1
公开(公告)日：2006-07-12
申请号：EP98946921.8
申请日：1998-09-04
申请人： Beth Israel Deaconess Medical Center , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
CPC分类号： C07K1/047 , A61K38/00 , C07K1/006 , C07K14/001
摘要： Peptides and peptide mimetics that inhibit phosphoserine- or phosphothreonine-specific pepidyl prolyl isomerases are described.
摘要翻译： 描述了抑制磷酸丝氨酸 - 或磷酸苏氨酸 - 特异性pepidyl脯氨酰异构酶的肽和肽模拟物。
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公开(公告)号：EP2370106A2
公开(公告)日：2011-10-05
申请号：EP09774835.4
申请日：2009-12-04
发明人： FISCHER, Gunter , MALESEVIC, Miroslav , ERDMANN, Frank , KÜHLING, Jan , BUKRINSKY, Michael , CONSTANT, Stephanie
CPC分类号： A61K49/0017 , A61K47/64 , A61K47/645 , A61K47/6455
摘要： The invention relates to an active ingredient-peptide construct for extracellular enrichment, to a method for enriching active ingredients in an extracellular space of a multicellular object, to the use of the active ingredient-peptide construct according to the invention for producing a pharmaceutical, and to a pharmaceutical composition comprising the active ingredient-peptide construct according to the invention.
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9.发明公开VERWENDUNG VON VON CYCLOHEXIMID ABGELEITETEN VERBINDUNGEN ZUR BEHANDLUNG ODER VORBEUGUNG VON INSBESONDERE ISCHÄMIEN UND HERZERKRANKUNGEN 审中-公开放线菌酮衍生化合物的使用，用于治疗或特别是缺血和心脏病的预防
公开(公告)号：EP2190430A1
公开(公告)日：2010-06-02
申请号：EP07801885.0
申请日：2007-08-24
CPC分类号： A61K31/45
摘要： The present invention relates to the use of certain derivatives of cycloheximide or the pharmaceutically acceptable salts thereof for the manufacture of a medicament for the treatment or prevention of ischaemias, of cardiopathies, of endothelial disorders, of traumata, of necroses, of pulmonary disorders, of vascular disorders, of forms of shock, of blood flow impairments or of stroke; or for the manufacture of a medicament for the treatment or prevention of diseases caused by ischaemia; or for the manufacture of a composition for the preservation and/or storage of transplants, especially of organs.
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