公开(公告)号：EP1545452A1

公开(公告)日：2005-06-29

申请号：EP03716788.9

申请日：2003-03-21

申请人： McNeil-PPC, Inc.

发明人： LI, Shun-Por ,  LEE, Der-Yang ,  MCNALLY, Gerard, P. ,  MCTEIGUE, Daniel ,  PARIKH, Narendra ,  SOWDEN, Harry, S. ,  WYNN, David

IPC分类号： A61K9/00

CPC分类号： A61K9/284 ,  A61K9/0004 ,  A61K9/2072 ,  A61K9/2077 ,  A61K9/2095 ,  A61K9/2893

摘要： A dosage form comprises: (a) at least one active ingredient; (b) a core having an outer surface; and (c) a shell which resides upon at least a portion of the core outer surface, wherein at least a portion of the shell is semipermeable, such that the liquid medium diffuses through the semipermeable shell or shell portion to the core due to osmosis. The shell also provides for delivery of the active ingredient to a liquid medium outside the shell after contacting of the dosage form with the liquid medium. The dosage form delivers one or more active ingredients in a controlled manner upon contacting of the dosage form with a liquid medium. The dosage form may be employed to provide a burst release of the active ingredient, or to provide release of the active ingredient at an ascending release rate over an extended time period upon contacting of the dosage form with a liquid medium.

公开(公告)号：EP1429738A2

公开(公告)日：2004-06-23

申请号：EP02783988.5

申请日：2002-09-28

申请人： McNeil-PPC, INC.

发明人： LEE, Der-Yang ,  LI, Shun-Por ,  PARIKH, Narendra ,  SOWDEN, Harry, S. ,  THOMAS, Martin ,  WYNN, David

IPC分类号： A61K9/20

CPC分类号： A23G3/04 ,  A23G1/54 ,  A23G3/0029 ,  A23G3/368 ,  A23G3/54 ,  A23L29/30 ,  A61J3/005 ,  A61J3/06 ,  A61J3/10 ,  A61K9/0004 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2068 ,  A61K9/2072 ,  A61K9/2081 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/282 ,  A61K9/2826 ,  A61K9/284 ,  A61K9/286 ,  A61K9/2873 ,  A61K9/2886 ,  A61K9/2893 ,  A61K9/5084 ,  B30B11/08 ,  B30B11/34 ,  B30B15/302 ,  Y10T428/1352

摘要： A dosage form comprises: (a) a core comprising at least one active ingredient; and (b) a molded shell which surrounds the core, wherein the shell provides a predetermined time delay of greater than one hour for the onset of dissolution of the active ingredient upon contacting of the dosage form with a liquid medium and the delay is independent of the pH of the liquid medium. The weight of the shell may be at least 50 percent of the weight of the core, and the shell may have a thickness of about 500-4000 microns, or be substantially free of pores having a diameter of 0.5 to 5 microns.

摘要翻译： 剂型包含：（a）包含至少一种活性成分的核心; 和（b）围绕核心的模制外壳，其中该外壳提供大于一小时的预定时间延迟，用于活性成分在剂型与液体介质接触时开始溶解，延迟独立于 液体介质的pH值。 壳的重量可以是芯的重量的至少50％，并且壳可以具有约500-4000微米的厚度，或者基本上不具有直径为0.5-5微米的孔。

公开(公告)号：EP1429737A1

公开(公告)日：2004-06-23

申请号：EP02773665.1

申请日：2002-09-28

申请人： McNeil-PPC, INC. ,  Thomas, Martin

发明人： LEE, Der-Yang ,  LI, Shun-Por ,  MCTEIGUE, Daniel ,  PARIKH, Narendra ,  SOWDEN, Harry, S. ,  THOMAS, Martin ,  WYNN, David

IPC分类号： A61K9/20 ,  A61K9/28

CPC分类号： A23G3/04 ,  A23G1/54 ,  A23G3/0029 ,  A23G3/368 ,  A23G3/54 ,  A23L29/30 ,  A61J3/005 ,  A61J3/06 ,  A61J3/10 ,  A61K9/0004 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2068 ,  A61K9/2072 ,  A61K9/2081 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/282 ,  A61K9/2826 ,  A61K9/284 ,  A61K9/286 ,  A61K9/2873 ,  A61K9/2886 ,  A61K9/2893 ,  A61K9/5084 ,  B30B11/08 ,  B30B11/34 ,  B30B15/302 ,  Y10T428/1352

摘要： A dosage form comprises: (a) at least one active ingredient; (b) a core; and(c) a shell which surrounds the core, wherein the shell is substantially free of pores having a diameter of 0.5-5.0 microns, and the shell comprises a first shell portion and a second shell portion which are compositionally different and the dosage form provides a modified release profile of the active ingredient upon contacting of the dosage form with a liquid medium. In another embodiment, the dosage form comprises: (a) at least one active ingredient; (b) a core comprising first and second core portions; and (c) a shell which surrounds the core, wherein the shell comprises first and second shell portions such that the first shell portion resides upon the first core portion and the second shell portion resides upon the second core portion, and at least one of the first or second shell portions or first or second shell portions provides a modified release profile of the active ingredient upon contacting of the dosage form with a liquid medium.

公开(公告)号：EP1429742B1

公开(公告)日：2011-05-04

申请号：EP02766427.5

申请日：2002-09-28

申请人： McNeil-PPC, Inc.

发明人： LEE, Der-Yang ,  LI, Shun-Por ,  PARIKH, Narendra ,  MCTEIGUE, Dan ,  SOWDEN, Harry, S. ,  THOMAS, Martin ,  WYNN, David

IPC分类号： A61K9/28

CPC分类号： A23G3/04 ,  A23G1/54 ,  A23G3/0029 ,  A23G3/368 ,  A23G3/54 ,  A23L29/30 ,  A61J3/005 ,  A61J3/06 ,  A61J3/10 ,  A61K9/0004 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2068 ,  A61K9/2072 ,  A61K9/2081 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/282 ,  A61K9/2826 ,  A61K9/284 ,  A61K9/286 ,  A61K9/2873 ,  A61K9/2886 ,  A61K9/2893 ,  A61K9/5084 ,  B30B11/08 ,  B30B11/34 ,  B30B15/302 ,  Y10T428/1352

摘要： In one embodiment, a dosage form comprises: (a) at least one active ingredient; (b) a molded core which is solid at room temperature; and (c) a shell which is in contact with at least a portion of the core, wherein the dosage form provides modified release of the active ingredient upon contacting of the dosage form with a liquid medium. In another embodiment of this invention, a dosage form comprises: (a) at least one active ingredient; (b) a molded core comprising a plurality of particles; and (c) a shell which is in contact with at least a portion of the core, wherein the dosage form provides modified release of the active ingredient upon contacting of the dosage form with a liquid medium.

公开(公告)号：EP1429738B1

公开(公告)日：2007-10-31

申请号：EP02783988.5

申请日：2002-09-28

申请人： McNEIL-PPC, Inc.

发明人： LEE, Der-Yang ,  LI, Shun-Por ,  PARIKH, Narendra ,  SOWDEN, Harry, S. ,  THOMAS, Martin ,  WYNN, David

IPC分类号： A61K9/20

CPC分类号： A23G3/04 ,  A23G1/54 ,  A23G3/0029 ,  A23G3/368 ,  A23G3/54 ,  A23L29/30 ,  A61J3/005 ,  A61J3/06 ,  A61J3/10 ,  A61K9/0004 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2068 ,  A61K9/2072 ,  A61K9/2081 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/282 ,  A61K9/2826 ,  A61K9/284 ,  A61K9/286 ,  A61K9/2873 ,  A61K9/2886 ,  A61K9/2893 ,  A61K9/5084 ,  B30B11/08 ,  B30B11/34 ,  B30B15/302 ,  Y10T428/1352

公开(公告)号：EP1429742A2

公开(公告)日：2004-06-23

申请号：EP02766427.5

申请日：2002-09-28

申请人： McNEIL-PPC, INC.

发明人： LEE, Der-Yang ,  LI, Shun-Por ,  PARIKH, Narendra ,  MCTEIGUE, Dan ,  SOWDEN, Harry, S. ,  THOMAS, Martin ,  WYNN, David

IPC分类号： A61K9/28

CPC分类号： A23G3/04 ,  A23G1/54 ,  A23G3/0029 ,  A23G3/368 ,  A23G3/54 ,  A23L29/30 ,  A61J3/005 ,  A61J3/06 ,  A61J3/10 ,  A61K9/0004 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2068 ,  A61K9/2072 ,  A61K9/2081 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/282 ,  A61K9/2826 ,  A61K9/284 ,  A61K9/286 ,  A61K9/2873 ,  A61K9/2886 ,  A61K9/2893 ,  A61K9/5084 ,  B30B11/08 ,  B30B11/34 ,  B30B15/302 ,  Y10T428/1352

摘要： In one embodiment, a dosage form comprises: (a) at least one active ingredient; (b) a molded core which is solid at room temperature; and (c) a shell which is in contact with at least a portion of the core, wherein the dosage form provides modified release of the active ingredient upon contacting of the dosage form with a liquid medium. In another embodiment of this invention, a dosage form comprises: (a) at least one active ingredient; (b) a molded core comprising a plurality of particles; and (c) a shell which is in contact with at least a portion of the core, wherein the dosage form provides modified release of the active ingredient upon contacting of the dosage form with a liquid medium.