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公开(公告)号：EP2170275B1
公开(公告)日：2012-11-21
申请号：EP08771808.6
申请日：2008-06-24
申请人： McNeil-PPC, Inc.
CPC分类号： A61K9/0056 , A61K9/209 , A61K31/485
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公开(公告)号：EP2170275A2
公开(公告)日：2010-04-07
申请号：EP08771808.6
申请日：2008-06-24
申请人： McNeil-PPC, Inc.
CPC分类号： A61K9/0056 , A61K9/209 , A61K31/485
摘要： The present invention relates to a dosage form including both a disintegrative tablet portion and a hard candy portion, wherein: (i) the disintegrative tablet portion comprises at least one pharmaceutically active agent, and (ii) the hard candy portion covers at least 20% of the surface of the disintegrative tablet portion, and wherein the disintegration time of the hard candy portion is at least ten times longer than the disintegration time of the disintegrative tablet portion.
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公开(公告)号：EP1545452A1
公开(公告)日：2005-06-29
申请号：EP03716788.9
申请日：2003-03-21
申请人： McNeil-PPC, Inc.
发明人： LI, Shun-Por , LEE, Der-Yang , MCNALLY, Gerard, P. , MCTEIGUE, Daniel , PARIKH, Narendra , SOWDEN, Harry, S. , WYNN, David
IPC分类号： A61K9/00
CPC分类号： A61K9/284 , A61K9/0004 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K9/2893
摘要： A dosage form comprises: (a) at least one active ingredient; (b) a core having an outer surface; and (c) a shell which resides upon at least a portion of the core outer surface, wherein at least a portion of the shell is semipermeable, such that the liquid medium diffuses through the semipermeable shell or shell portion to the core due to osmosis. The shell also provides for delivery of the active ingredient to a liquid medium outside the shell after contacting of the dosage form with the liquid medium. The dosage form delivers one or more active ingredients in a controlled manner upon contacting of the dosage form with a liquid medium. The dosage form may be employed to provide a burst release of the active ingredient, or to provide release of the active ingredient at an ascending release rate over an extended time period upon contacting of the dosage form with a liquid medium.
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公开(公告)号：EP1438030A2
公开(公告)日：2004-07-21
申请号：EP02799689.1
申请日：2002-09-28
申请人： McNEIL-PPC, INC.
发明人： LEE, Der-Yang , LI, Shun-Por , SOWDEN, Harry, S. , THOMAS, Martin , WYNN, David
IPC分类号： A61K9/28
CPC分类号： A23G3/04 , A23G1/54 , A23G3/0029 , A23G3/368 , A23G3/54 , A23L29/30 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0004 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2081 , A61K9/209 , A61K9/2095 , A61K9/282 , A61K9/2826 , A61K9/284 , A61K9/286 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K9/5084 , B30B11/08 , B30B11/34 , B30B15/302 , Y10T428/1352
摘要： A dosage form comprises: (a) at least one active ingredient: (b) a core having a first surface portion upon which resides a first coating and a second surface portion which is substantially free of the first coating; and (c) a shell which resides upon at least a portion of the second surface portion, wherein the shell comprises a different material from the first coating. In another embodiment, the dosage form comprises: (a) at least one active ingredient; (b)a core comprising a center portion having an exterior surface and an annular portion having an exterior surface and an interior surface, wherein the annular portion interior surface is in contact with at least a portion of the center portion exterior surface, and a coating resides on at least a portion of the annular portion exterior surface; and (c) a shell which resides upon at least a portion of the exterior surface of the center portion, wherein the shell comprises a different material than the impermeable coating. In another embodiment, the dosage form comprises: (a) at least one active ingredient; (b) a core having an outer surface and a cavity which extends at least partially through the core such that the core outer surface has at least a first opening therein; (c) a first coating which resides on at least a portion of the core outer surface, wherein the first shell portion comprises a different material from the first coating; and (d) a first shell portion which is adjacent to the first opening and covers at least the first opening.
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公开(公告)号：EP1429737A1
公开(公告)日：2004-06-23
申请号：EP02773665.1
申请日：2002-09-28
申请人： McNeil-PPC, INC. , Thomas, Martin
发明人： LEE, Der-Yang , LI, Shun-Por , MCTEIGUE, Daniel , PARIKH, Narendra , SOWDEN, Harry, S. , THOMAS, Martin , WYNN, David
CPC分类号： A23G3/04 , A23G1/54 , A23G3/0029 , A23G3/368 , A23G3/54 , A23L29/30 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0004 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2081 , A61K9/209 , A61K9/2095 , A61K9/282 , A61K9/2826 , A61K9/284 , A61K9/286 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K9/5084 , B30B11/08 , B30B11/34 , B30B15/302 , Y10T428/1352
摘要： A dosage form comprises: (a) at least one active ingredient; (b) a core; and(c) a shell which surrounds the core, wherein the shell is substantially free of pores having a diameter of 0.5-5.0 microns, and the shell comprises a first shell portion and a second shell portion which are compositionally different and the dosage form provides a modified release profile of the active ingredient upon contacting of the dosage form with a liquid medium. In another embodiment, the dosage form comprises: (a) at least one active ingredient; (b) a core comprising first and second core portions; and (c) a shell which surrounds the core, wherein the shell comprises first and second shell portions such that the first shell portion resides upon the first core portion and the second shell portion resides upon the second core portion, and at least one of the first or second shell portions or first or second shell portions provides a modified release profile of the active ingredient upon contacting of the dosage form with a liquid medium.
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公开(公告)号：EP1545472B1
公开(公告)日：2010-12-08
申请号：EP03798655.1
申请日：2003-03-21
申请人： McNeil-PPC, Inc.
IPC分类号： A61K9/20
CPC分类号： A61K9/284 , A61K9/0004 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K9/2893
摘要： A modified release dosage form comprising at least one active ingredient and at least two cores surrounded by a shell is provided. The shell comprises at least one opening and provides for modified release of active ingredient upon contacting of the dosage form with a liquid medium. At least one of the cores is distal from the opening. In a preferred embodiment, the dosage form has a pulsatile release profile.
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公开(公告)号：EP1542661A1
公开(公告)日：2005-06-22
申请号：EP03716781.4
申请日：2003-03-21
申请人： McNeil-PPC, Inc.
CPC分类号： A61K9/284 , A61K9/0004 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K9/2893
摘要： The invention provides a dosage form comprising at least one active ingredient, and first core and second cores surrounded by and separated by a shell. The dosage form provides a delay of at least one hour between the initial release of active ingredient contained in said first core and the initial release of active ingredient contained in said second core after contacting of the dosage form with a liquid medium.
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公开(公告)号：EP1438028A1
公开(公告)日：2004-07-21
申请号：EP02799682.6
申请日：2002-09-28
申请人： McNEIL-PPC, INC.
发明人： LEE, Der-Yang , LI, Shun-Por , SOWDEN, Henry, S. , THOMAS, Martin , WYNN, David
IPC分类号： A61K9/20
CPC分类号： A23G3/04 , A23G1/54 , A23G3/0029 , A23G3/368 , A23G3/54 , A23L29/30 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0004 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2081 , A61K9/209 , A61K9/2095 , A61K9/282 , A61K9/2826 , A61K9/284 , A61K9/286 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K9/5084 , B30B11/08 , B30B11/34 , B30B15/302 , Y10T428/1352
摘要： In one embodiment a dosage form comprises at least one active ingredient and a molded matrix which comprises from 10 to 100% of a material having a melting point of less than about 100 degrees C selected from the stamp consisting of thermoplastic polyalkylene oxides, low melting hydrophobic materials, thermoplastic polymers, thermoplastic starches and combinations thereof, and the matrix is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium. The dosage form may additionally comprise uncoated particles which may contain at least one active ingredient. In another embodiment, a dosage form comprises at least one active ingredient, a plurality of particles and a molded matrix, wherein at least a portion of the particles are coated. The coated particles, the matrix or both may comprise at least one active ingredient, and the coated particles or the matrix or a combination thereof is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium.
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公开(公告)号：EP1429738A2
公开(公告)日：2004-06-23
申请号：EP02783988.5
申请日：2002-09-28
申请人： McNeil-PPC, INC.
发明人： LEE, Der-Yang , LI, Shun-Por , PARIKH, Narendra , SOWDEN, Harry, S. , THOMAS, Martin , WYNN, David
IPC分类号： A61K9/20
CPC分类号： A23G3/04 , A23G1/54 , A23G3/0029 , A23G3/368 , A23G3/54 , A23L29/30 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0004 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2081 , A61K9/209 , A61K9/2095 , A61K9/282 , A61K9/2826 , A61K9/284 , A61K9/286 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K9/5084 , B30B11/08 , B30B11/34 , B30B15/302 , Y10T428/1352
摘要： A dosage form comprises: (a) a core comprising at least one active ingredient; and (b) a molded shell which surrounds the core, wherein the shell provides a predetermined time delay of greater than one hour for the onset of dissolution of the active ingredient upon contacting of the dosage form with a liquid medium and the delay is independent of the pH of the liquid medium. The weight of the shell may be at least 50 percent of the weight of the core, and the shell may have a thickness of about 500-4000 microns, or be substantially free of pores having a diameter of 0.5 to 5 microns.
摘要翻译： 剂型包含：（a）包含至少一种活性成分的核心; 和（b）围绕核心的模制外壳，其中该外壳提供大于一小时的预定时间延迟，用于活性成分在剂型与液体介质接触时开始溶解，延迟独立于 液体介质的pH值。 壳的重量可以是芯的重量的至少50％，并且壳可以具有约500-4000微米的厚度，或者基本上不具有直径为0.5-5微米的孔。
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公开(公告)号：EP1542661B1
公开(公告)日：2013-12-18
申请号：EP03716781.4
申请日：2003-03-21
申请人： McNeil-PPC, Inc.
CPC分类号： A61K9/284 , A61K9/0004 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K9/2893
摘要： The invention provides an immediate release dosage form having a solid core and a shell readily soluble in gastrointestinal fluids. The dosage form also comprises one or more openings in the shell.
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