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    Method for handling and mixing droplets
    9.
    发明公开
    Method for handling and mixing droplets 审中-公开
    Verfahren zur Handhabung und Mischung vonTröpfchen

    公开(公告)号：EP2662136A2

    公开(公告)日：2013-11-13

    申请号：EP13165667.0

    申请日：2004-08-27

    申请人： President and Fellows of Harvard College

    发明人： Link, Darren ,  Weitz, David ,  Cristobal-Azkarte, Glader ,  Cheng, Zhengdong ,  Ahn, Keunho

    IPC分类号： B01J19/00 ,  G01N15/14

    CPC分类号： B01L3/5027 ,  B01F5/0256 ,  B01F5/0646 ,  B01F5/0655 ,  B01F5/0682 ,  B01F5/0689 ,  B01F13/0069 ,  B01F13/0071 ,  B01F13/0074 ,  B01F13/0076 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00862 ,  B01L3/0241 ,  B01L3/502761 ,  B01L3/502776 ,  B01L3/502784 ,  B01L3/502792 ,  B01L3/5088 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2200/0673 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/161 ,  B01L2400/0415 ,  B01L2400/0439 ,  B01L2400/0487 ,  C12Q2563/159 ,  C12Q2565/629 ,  G01N15/10 ,  G01N15/14 ,  G01N15/1459 ,  G01N15/1484 ,  G01N2015/1006 ,  G01N2015/1081 ,  G01N2015/149 ,  Y10S436/807 ,  Y10T436/118339 ,  Y10T436/2525 ,  Y10T436/2575

    摘要： Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid etc. In some cases, the droplets may each have a substantially uniform number of entities therein. For example, 95% or more of the droplets may each contain the same number of entities of a particular species. In another aspect, the invention relates to systems and methods for dividing a fluidic droplet into two droplets, for example, through charge and/or dipole interactions with an electric field. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In a related aspect of the invention, systems and methods for allowing fluid mixing within droplets to occur are also provided. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets. In some cases, the fluidic droplets can be sorted at relatively high rates, e.g., at about 10 droplets per second or more. Another aspect of the invention provides the ability to determine droplets, or a component thereof, for example, using fluorescence and/or other optical techniques (e.g., microscopy), or electric sensing techniques such as dielectric sensing.

    摘要翻译： 本发明的各个方面涉及流体物质的控制和操作，例如在微流体系统中。 一方面，本发明涉及使用例如电场，机械改变，中间流体等的添加来制造由液体包围的流体液滴的系统和方法。在一些情况下，液滴可以具有 基本上统一的实体数量。 例如，95％或更多的液滴可以各自包含相同数量的特定物质的实体。 另一方面，本发明涉及用于将流体液滴分成两个液滴的系统和方法，例如通过与电场的电荷和/或偶极相互作用。 本发明还涉及根据本发明的另一方面，例如通过电荷和/或偶极相互作用来熔融液滴的系统和方法。 在一些情况下，液滴的融合可以引发或确定反应。 在本发明的相关方面，还提供了用于允许在液滴内进行流体混合的系统和方法。 在另一方面，本发明涉及用于分选液滴的系统和方法，例如通过使液滴移动到流体系统内的某些区域。 实例包括使用电相互作用（例如电荷，偶极子等）或机械系统（例如，流体位移）来对液滴进行分类。 在一些情况下，流体液滴可以以相对高的速率进行分选，例如每秒大约10个液滴或​​更多。 本发明的另一方面提供了例如使用荧光和/或其他光学技术（例如显微镜）或诸如电介质感测的电传感技术来确定液滴或其组分的能力。

    Method for mixing droplets in a microchannel
    10.
    发明公开
    Method for mixing droplets in a microchannel 审中-公开
    埃及米克罗卡纳尔（Vervahren Zur Mischung vonTröpfchen）

    公开(公告)号：EP2662135A2

    公开(公告)日：2013-11-13

    申请号：EP13165665.4

    申请日：2004-08-27

    申请人： President and Fellows of Harvard College

    发明人： Link, Darren R. ,  Weitz, David A. ,  Cristobal-Azkarte, Glader ,  Cheng, Zhengdong ,  Ahn, Keunho

    IPC分类号： B01J19/00 ,  G01N15/14

    CPC分类号： B01L3/5027 ,  B01F5/0256 ,  B01F5/0646 ,  B01F5/0655 ,  B01F5/0682 ,  B01F5/0689 ,  B01F13/0069 ,  B01F13/0071 ,  B01F13/0074 ,  B01F13/0076 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00862 ,  B01L3/0241 ,  B01L3/502761 ,  B01L3/502776 ,  B01L3/502784 ,  B01L3/502792 ,  B01L3/5088 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2200/0673 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/161 ,  B01L2400/0415 ,  B01L2400/0439 ,  B01L2400/0487 ,  C12Q2563/159 ,  C12Q2565/629 ,  G01N15/10 ,  G01N15/14 ,  G01N15/1459 ,  G01N15/1484 ,  G01N2015/1006 ,  G01N2015/1081 ,  G01N2015/149 ,  Y10S436/807 ,  Y10T436/118339 ,  Y10T436/2525 ,  Y10T436/2575

    摘要： Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid etc. In some cases, the droplets may each have a substantially uniform number of entities therein. For example, 95% or more of the droplets may each contain the same number of entities of a particular species. In another aspect, the invention relates to systems and methods for dividing a fluidic droplet into two droplets, for example, through charge and/or dipole interactions with an electric field. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In a related aspect of the invention, systems and methods for allowing fluid mixing within droplets to occur are also provided. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets. In some cases, the fluidic droplets can be sorted at relatively high rates, e.g., at about 10 droplets per second or more. Another aspect of the invention provides the ability to determine droplets, or a component thereof, for example, using fluorescence and/or other optical techniques (e.g., microscopy), or electric sensing techniques such as dielectric sensing.

    摘要翻译： 本发明的各个方面涉及流体物质的控制和操作，例如在微流体系统中。 一方面，本发明涉及使用例如电场，机械改变，中间流体等的添加来制造由液体包围的流体液滴的系统和方法。在一些情况下，液滴可以具有 基本上统一的实体数量。 例如，95％或更多的液滴可以各自包含相同数量的特定物种的实体。 另一方面，本发明涉及用于将流体液滴分成两个液滴的系统和方法，例如通过与电场的电荷和/或偶极相互作用。 本发明还涉及根据本发明的另一方面，例如通过电荷和/或偶极相互作用来熔融液滴的系统和方法。 在一些情况下，液滴的融合可以引发或确定反应。 在本发明的相关方面，还提供了用于允许在液滴内进行流体混合的系统和方法。 在另一方面，本发明涉及用于分选液滴的系统和方法，例如通过使液滴移动到流体系统内的某些区域。 实例包括使用电相互作用（例如电荷，偶极子等）或机械系统（例如，流体位移）来对液滴进行分类。 在一些情况下，流体液滴可以以相对高的速率进行分选，例如每秒大约10个液滴或​​更多。 本发明的另一方面提供了例如使用荧光和/或其他光学技术（例如显微镜）或诸如电介质感测的电传感技术来确定液滴或其组分的能力。