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1.发明授权HEPATITIS B VIRUS DNA POLYMERASE AND SURFACE ANTIGEN VARIANTS AND METHODS OF USING SAME 有权乙型肝炎病毒DNA聚合酶和表面抗原变体及其使用方法IHER
公开(公告)号：EP1297109B1
公开(公告)日：2011-11-23
申请号：EP01937883.5
申请日：2001-06-08
发明人： BARTHOLOMEUSZ, Angeline, Ingrid , LOCARNINI, Stephen, Alister , AYRES, Anna , LITTLEJOHN, Margaret, Rose , MCCAUGHAN, Geoffrey, William , ANGUS, Peter, William
CPC分类号： C07K14/005 , A61K2039/525 , C12N9/1252 , C12N2730/10122 , C12Q1/706 , C12Q2600/156
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to agents and in particular nucleoside analogues. More particularly, the present invention is directed to hepatitis B virus variants exhibiting complete or partial resistance to nucleoside analogues. The variants may also comprise corresponding mutations affecting immunological interactivity to viral surface components. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic regimes and in developing new or modified vaccines directed against viral agents and in particular hepatitis B virus variants. The present invention also contemplates the use of the viral variants to screen for agents capable of inhibiting infection, replication and/or release of the virus.
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2.发明公开HEPATITIS B VIRUS DNA POLYMERASE AND SURFACE ANTIGEN VARIANTS AND METHODS OF USING SAME 有权乙型肝炎病毒DNA聚合酶和表面抗原变体及其使用方法IHER
公开(公告)号：EP1297109A1
公开(公告)日：2003-04-02
申请号：EP01937883.5
申请日：2001-06-08
发明人： BARTHOLOMEUSZ, Angeline, Ingrid , LOCARNINI, Stephen, Alister , AYRES, Anna , LITTLEJOHN, Margaret, Rose , MCCAUGHAN, Geoffrey, William , ANGUS, Peter, William
CPC分类号： C07K14/005 , A61K2039/525 , C12N9/1252 , C12N2730/10122 , C12Q1/706 , C12Q2600/156
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to agents and in particular nucleoside analogues. More particularly, the present invention is directed to hepatitis B virus variants exhibiting complete or partial resistance to nucleoside analogues. The variants may also comprise corresponding mutations affecting immunological interactivity to viral surface components. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic regimes and in developing new or modified vaccines directed against viral agents and in particular hepatitis B virus variants. The present invention also contemplates the use of the viral variants to screen for agents capable of inhibiting infection, replication and/or release of the virus.
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