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    ANTIVIRAL RESISTANCE MUTANTS AND APPLICATIONS THEREOF
    4.
    发明公开
    ANTIVIRAL RESISTANCE MUTANTS AND APPLICATIONS THEREOF 有权
    抗病毒耐药性突变体及其应用

    公开(公告)号：EP1948800A1

    公开(公告)日：2008-07-30

    申请号：EP06790408.6

    申请日：2006-10-20

    申请人： Melbourne Health ,  Austin Health

    发明人： BARTHOLOMEUSZ, Angeline, Ingrid ,  LOCARNINI, Stephen ,  AYRES, Anna ,  LITTLEJOHN, Margaret ,  ANGUS, Peter, William

    IPC分类号： C12N15/51 ,  A61K35/76 ,  C12N7/06

    CPC分类号： A61K35/76 ,  C12N7/00 ,  C12N2730/10132 ,  C12Q1/18

    摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to agents such as nucleoside or nucleotide analogs or other DNA polymerase antagonists and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs or other DNA polymerase antagonists and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.

    VIRAL VARIANTS
    5.
    发明公开
    VIRAL VARIANTS 审中-公开
    病毒变异

    公开(公告)号：EP1169452A1

    公开(公告)日：2002-01-09

    申请号：EP00915035.0

    申请日：2000-04-07

    申请人： Melbourne Health

    发明人： BARTHOLOMEUSZ, Angeline ,  LITTLEJOHN, Margaret ,  AYRES, Anna ,  LOCARNINI, Stephen

    IPC分类号： C12N15/13 ,  C12N7/01 ,  C12N15/36

    CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/005 ,  C07K16/082 ,  C12N2730/10122

    摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus variants exhibiting complete or partial resistance to nucleoside analogues and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic regimes and in developing new or modified vaccines directed against viral agents and in particular hepatitis B virus variants.

    ANTIVIRAL RESISTANCE MUTANTS AND APPLICATIONS THEREOF
    7.
    发明授权
    ANTIVIRAL RESISTANCE MUTANTS AND APPLICATIONS THEREOF 有权
    ANTIVIRALE RESISTENZMUTANTEN UND DEREN ANWENDUNGEN

    公开(公告)号：EP1948800B1

    公开(公告)日：2015-12-23

    申请号：EP06790408.6

    申请日：2006-10-20

    申请人： Melbourne Health ,  Austin Health

    发明人： BARTHOLOMEUSZ, Angeline, Ingrid ,  LOCARNINI, Stephen ,  AYRES, Anna ,  LITTLEJOHN, Margaret ,  ANGUS, Peter, William

    IPC分类号： C12N15/51 ,  A61K35/76 ,  C12N7/06

    CPC分类号： A61K35/76 ,  C12N7/00 ,  C12N2730/10132 ,  C12Q1/18

    摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to agents such as nucleoside or nucleotide analogs or other DNA polymerase antagonists and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs or other DNA polymerase antagonists and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.

    摘要翻译： 本发明一般涉及对诸如核苷或核苷酸类似物或其他DNA聚合酶拮抗剂的药物的敏感性降低和/或与免疫试剂降低的相互作用的病毒变体。 更具体地，本发明涉及对核苷或核苷酸类似物或其他DNA聚合酶拮抗剂表现出完全或部分抗性和/或降低与病毒表面成分抗体的相互作用的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。 本发明进一步考虑了用于检测这种病毒变体的测定法，该测定法可用于监测抗病毒治疗方案和开发针对病毒剂，特别是HBV变体的新的或修饰的疫苗。 本发明还考虑使用病毒变体来筛选和/或开发或设计能够抑制病毒感染，复制和/或释放的试剂。