公开(公告)号：EP1363655A2

公开(公告)日：2003-11-26

申请号：EP01993274.8

申请日：2001-12-14

申请人： Merck & Co., Inc.

发明人： LIU, Qingyun ,  CLEMENTS, Michelle ,  MCDONALD, Terrence, P.

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C07K14/00 ,  C07K14/47 ,  G01N33/53

CPC分类号： G01N33/5091 ,  C07K14/705 ,  C12Q1/6883 ,  C12Q1/6897 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5041 ,  G01N33/566 ,  G01N2333/726

摘要： Disclosed herein are newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polypeptides by recombinant techniques. More particularly, the polynucleotides and polypeptides of the present invention relate to a G-Protein coupled receptor protein, hereinafter referred to as Human GPR54 (GPR54), which happens to be an orphan receptor protein. The invention also relates to inhibiting or activating the action of such polynucleotides and polypeptides.

公开(公告)号：EP1133515A1

公开(公告)日：2001-09-19

申请号：EP99962792.0

申请日：1999-11-18

申请人： Merck & Co., Inc.

发明人： LIU, Qingyun ,  MCDONALD, Terrence, P.

IPC分类号： C07H21/04 ,  C07K14/00 ,  C07K16/28 ,  C12N1/21 ,  C12N5/02 ,  C12N15/00 ,  C12P21/00 ,  G01N33/53 ,  G01N33/567

CPC分类号： C07K14/705

摘要： A cDNA encoding a novel human G-protein-coupled receptor, HG51, as well as the protein encoded by the cDNA, is provided. Methods of identifying agonists and antagonists of HG51 are also provided.

公开(公告)号：EP1017811A1

公开(公告)日：2000-07-12

申请号：EP98949466.1

申请日：1998-09-24

申请人： MERCK & CO., INC.

发明人： LIU, Qingyun ,  BAILEY, Wendy, J. ,  MCDONALD, Terrence, P.

IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N15/00 ,  C12P21/02 ,  C07K14/47 ,  C07K16/00 ,  G01N33/53 ,  C12Q1/68

CPC分类号： C12N15/8509 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C07K14/723 ,  C12Q1/68 ,  C12Q1/6876 ,  C12Q1/6897 ,  C12Q2600/158

摘要： This invention provides a novel G-protein coupled glycoprotein hormone receptor HG38, mutant and polymorphic forms of the receptor, nucleic acids encoding the same, expression vectors including the nucleic acids, host cells transformed with nucleic acids, transgenic knockout animals lacking the receptor and transgenic animals expressing a non-native receptor gene, antibodies against the receptor and polypeptides thereof and assays for modulators, agonists and antagonists of the receptor. The receptor proteins and polypeptides, nucleic acids, cells, animals and assays of this invention are useful in drug screening and development, diagnosis and therapeutic applications.

公开(公告)号：EP1233981A1

公开(公告)日：2002-08-28

申请号：EP00978622.9

申请日：2000-11-14

申请人： Merck & Co., Inc. ,  BANYU PHARMACEUTICAL CO., LTD.

发明人： LIU, Qingyun ,  MCDONALD, Terrence, P. ,  HOWARD, Andrew, D. ,  IWAASA, Hisashi ,  SANO, Hideki

IPC分类号： C07K14/05 ,  C07K14/71 ,  C07K16/18 ,  C07K16/22 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  G01N33/53 ,  G01N33/567 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C12N15/64

CPC分类号： C07K14/723 ,  A61K38/00

摘要： The present invention features HG67 nucleic acids and HG67 polypeptides. HG67, also referred to herein as 'MCH-R2', is a G-protein coupled receptor having a high degree of sequence identity with MCH-R1. The amino acid sequence for HG67 is provided by SEQ. ID. NO. 1. The cDNA sequence of HG67 is provided by SEQ. ID. NO. 2.

公开(公告)号：EP1017709A1

公开(公告)日：2000-07-12

申请号：EP98951942.6

申请日：1998-09-24

申请人： MERCK & CO., INC.

发明人： LIU, Qingyun ,  ABRAMOVITZ, Mark ,  MCDONALD, Terrence, P. ,  O'NEILL, Gary, P. ,  WANG, Ruiping

IPC分类号： C07H21/04

CPC分类号： G01N33/5091 ,  A01K2217/05 ,  A01K2217/075 ,  C07K14/723 ,  G01N33/5008 ,  G01N33/502 ,  G01N2333/726

摘要： This invention provides a novel G-protein coupled glycoprotein hormone receptor AOMF05, mutant and polymorphic forms of the receptor, nucleic acids encoding the same, expression vectors including the nucleic acids, host cells transformed with nucleic acids, transgenic knockout animals lacking the receptor and transgenic animals expressing a non-native receptor gene, antibodies against the receptor and polypeptides thereof and assays for modulators, agonists and antagonists of the receptor. The receptor proteins and polypeptides, nucleic acids, cells, animals and assays of this invention are useful in drug screening and development, diagnosis and therapeutic applications.