公开(公告)号：EP3419606B1

公开(公告)日：2019-12-25

申请号：EP17701268.9

申请日：2017-01-24

申请人： Merck Patent GmbH

发明人： BENK, Harald ,  BIRK, Gudrun ,  DECKER, Melina ,  LUBDA, Dieter ,  MODDELMOG, Guenter ,  MUESSIG, Harald ,  SCARAMUZZA, Tanino ,  SCHLEEHAHN, Michael

IPC分类号： A61K9/16 ,  B01J2/22 ,  C07C229/08

公开(公告)号：EP3247334A1

公开(公告)日：2017-11-29

申请号：EP15817080.3

申请日：2015-12-22

申请人： Merck Patent GmbH

发明人： KUCERA, Shawn ,  LUBDA, Dieter ,  MILLER, Dave ,  BROUGH, Chris

IPC分类号： A61K9/14 ,  A61K31/192 ,  A61K31/4422 ,  A61K31/496

CPC分类号： A61K9/146 ,  A61K31/192 ,  A61K31/4422 ,  A61K31/496

摘要： The present invention refers to a method for producing storage-stable solid dispersions of poorly soluble pharmaceutically active compounds comprising polyvinyl alcohol as carrier matrix. The invention also refers to the prepared compositions and their use.

公开(公告)号：EP2897645A1

公开(公告)日：2015-07-29

申请号：EP13755955.5

申请日：2013-08-19

申请人： Merck Patent GmbH

发明人： MODDELMOG, Guenter ,  OGNIBENE, Roberto ,  WEDEL, Thorsten ,  LUBDA, Dieter

IPC分类号： A61K47/02

CPC分类号： A61K47/02 ,  A61K9/1611 ,  A61K31/375 ,  A61K31/525

摘要： The present invention relates to solid formulations which contain at least one porous carrier and one or more functional substances in a stable mixture, and to the use thereof.

摘要翻译： 本发明涉及含有至少一种多孔载体和稳定混合物中的一种或多种功能性物质的固体制剂及其用途。

公开(公告)号：EP1269179B1

公开(公告)日：2009-04-29

申请号：EP01919385.3

申请日：2001-03-13

申请人： Merck Patent GmbH

发明人： CABRERA, Karin ,  KRAUS, Alexander ,  NEUROTH, Willi ,  LUBDA, Dieter

IPC分类号： G01N30/00

CPC分类号： B01J20/281 ,  B01J20/28042 ,  B01J2220/54 ,  B01J2220/82 ,  G01N30/60 ,  G01N2030/528

摘要： The invention relates to monolithic sorbents with a fiber-reinforced plastic coating. By using fiber-reinforced plastic with a viscosity 40 - 100 ml/10 min according to the MVI-method, the coating can be applied to the shaped body with a low dead volume and possesses sufficient mechanical stability.

公开(公告)号：EP1155316B1

公开(公告)日：2007-04-11

申请号：EP00916851.9

申请日：2000-02-21

申请人： Merck Patent GmbH ,  Evotec AG

发明人： UNGER, Klaus ,  BOOS, Karl-Siegfried ,  LUBDA, Dieter ,  MUSCATE-MAGNUSSEN, Angelika

IPC分类号： G01N27/447 ,  B01J20/281

CPC分类号： G01N27/44747

摘要： The invention relates to the use of supporting material for carrying out capillary electrochromatography, whereby the supporting material based on a base material containing hydroxyl groups has reversed phases which are restricted to the inner surfaces of porous particles, and these reversed phases are comprised of fatty acid esters. The invention also relates to capillary columns which are suited for carrying out the inventive use of reversed phase supporting material in capillary electrochromatography.

公开(公告)号：EP1562700A1

公开(公告)日：2005-08-17

申请号：EP03809725.9

申请日：2003-10-21

申请人： MERCK PATENT GmbH

发明人： BAYRAM-HAHN, Zöfre ,  UNGER, Klaus ,  HENDRIKS, Robertus ,  LUBDA, Dieter

IPC分类号： B01J20/32 ,  G01N30/48

CPC分类号： B01J20/261 ,  B01J20/103 ,  B01J20/264 ,  B01J20/28042 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/28092 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3257 ,  B01J20/327 ,  B01J20/3276 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/82 ,  B01J2220/825 ,  G01N2030/525 ,  Y10T428/249967 ,  Y10T428/249969 ,  Y10T428/249978 ,  Y10T428/249979 ,  Y10T428/249991 ,  Y10T428/249992

摘要： The invention relates to inorganic, monolithic moulded bodies, whose surface is coated with physically or chemically adsorbed organic polymers, in addition to a method for producing materials of this type. The inventive materials are particularly suitable for use as sorbents for chromatography, in particular for the high-pressure liquid chromatography of biological materials.

公开(公告)号：EP1194201B1

公开(公告)日：2003-08-20

申请号：EP00945798.7

申请日：2000-06-21

申请人： MERCK PATENT GmbH

发明人： LUBDA, Dieter ,  SÄTTLER, Günther ,  NEUROTH, Willi ,  HAUKE, Günter ,  CABRERA, Karin

IPC分类号： B01D15/08

CPC分类号： G01N30/6052 ,  B01D15/08

摘要： The invention relates to tubes used for chromatography that consist of fiber-reinforced synthetic material, preferably carbon or glass-fiber reinforced PEEK. The inventive reinforcement materials substantially improve the mechanical stability of the columns and reduce the absorption of humidity by the synthetic material.

公开(公告)号：EP0912242A1

公开(公告)日：1999-05-06

申请号：EP97937469.0

申请日：1997-07-08

申请人： MERCK PATENT GmbH

发明人： MÜLLER, Egbert ,  LUBDA, Dieter ,  WIELAND, Gerhard ,  CABRERA, Karin ,  CZERNY, Kristina ,  DICKS, Edith

IPC分类号： B01J20 ,  B01D15 ,  C08G69 ,  C08G81 ,  C12N11 ,  G01N30

CPC分类号： B01J20/29 ,  B01D15/1821 ,  B01J20/28033 ,  B01J20/28042 ,  B01J20/28054 ,  B01J20/28078 ,  B01J20/28092 ,  B01J20/283 ,  B01J20/285 ,  B01J20/286 ,  B01J20/287 ,  B01J20/3204 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3257 ,  B01J20/3263 ,  B01J2220/54 ,  B01J2220/82 ,  C08G69/48 ,  C08G81/028 ,  C12N11/08 ,  G01N2030/528

摘要： The invention concerns non-particulate sorbents which are modified by chiral groups, for example on the basis of monolithic base carriers or derivatized polyamide membranes. These sorbents permit high flow rates during enantiomer separation.

公开(公告)号：EP4069202A1

公开(公告)日：2022-10-12

申请号：EP20811630.1

申请日：2020-11-27

申请人： Merck Patent GmbH

发明人： LUBDA, Dieter ,  BIRK, Gudrun

IPC分类号： A61K9/19 ,  A61K47/02 ,  A61K47/20 ,  A61K47/38 ,  A61K31/03 ,  A61K31/4196 ,  A61K9/14

公开(公告)号：EP3911303A1

公开(公告)日：2021-11-24

申请号：EP20700831.9

申请日：2020-01-17

申请人： Merck Patent GmbH

发明人： LUBDA, Dieter ,  KIPPING, Thomas

IPC分类号： A61K9/16 ,  A61J3/06 ,  A61K9/20 ,  A61K31/00 ,  A61K9/14 ,  A61K47/32