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1.发明授权
公开(公告)号：EP2683687B1
公开(公告)日：2017-04-19
申请号：EP12709453.0
申请日：2012-03-05
发明人： SHAH, Shrenik, K. , ALI, Amjad , LO, Michael Man-Chu , WHITEHEAD, Brent , HENDERSON, Timothy, J. , YAN, Lin , GUO, Zhiqiang
IPC分类号： C07D207/12 , C07D207/48 , C07D211/46 , C07D211/96 , C07D223/08 , C07D309/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12 , C07D207/273 , A61K31/445
CPC分类号： C07D211/46 , C07D207/12 , C07D207/273 , C07D207/48 , C07D211/96 , C07D223/08 , C07D309/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12
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公开(公告)号：EP2632255A1
公开(公告)日：2013-09-04
申请号：EP11836944.6
申请日：2011-10-25
发明人： ALI, Amjad , LO, Michael Man-Chu , BAKER, Robert, K. , GUO, Zhiqiang , WHITEHEAD, Brent , HENDERSON, Timothy, J. , METZGER, Edward , YAN, Lin , SHAH, Shrenik, K. , DELLUREFICIO, James , WANG, Jun
IPC分类号： A01N33/26 , A61K31/655
CPC分类号： C07D211/44 , A61K31/655 , C07D205/04 , C07D207/12 , C07D207/16 , C07D207/273 , C07D307/20 , C07D309/12 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D413/04 , C07D413/10 , C07D417/04
摘要： A compound having the structure: useful for treating hypertension, Pulmonary Arterial Hypertension (PAH), congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.
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公开(公告)号：EP2387574A1
公开(公告)日：2011-11-23
申请号：EP10700293.3
申请日：2010-01-12
发明人： DU, Wu , HAGMANN, William, K. , HE, Shuwen , LAI, Zhong , SHAH, Shrenik, K. , TRUONG, Quang, T.
IPC分类号： C07D471/04 , A61K31/407 , A61K31/437
CPC分类号： C07D471/04
摘要： Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety. Formula (I).
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公开(公告)号：EP1496838B1
公开(公告)日：2010-11-03
申请号：EP03714051.4
申请日：2003-03-07
发明人： HAGMANN, William, K. , LIN, Linus, S. , SHAH, Shrenik, K. , GUTHIKONDA, Ravindra, N. , QI, Hongbo , CHANG, Linda, L. , LIU, Ping , ARMSTRONG, Helen, M. , JEWELL, James, P. , LANZA, Thomas, J., Jr.
IPC分类号： C07C233/05 , C07D213/02 , C07D213/62 , C07D401/02 , A61K31/165 , A61K31/44 , A61K31/505
CPC分类号： C07D213/64 , C07C233/13 , C07C235/06 , C07C235/20 , C07C235/34 , C07C235/74 , C07C235/78 , C07C237/06 , C07C255/55 , C07C255/60 , C07C271/14 , C07C271/22 , C07C275/30 , C07C311/03 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D209/34 , C07D209/94 , C07D211/34 , C07D213/65 , C07D213/68 , C07D215/06 , C07D231/12 , C07D233/56 , C07D233/70 , C07D237/28 , C07D237/32 , C07D239/34 , C07D249/04 , C07D249/08 , C07D249/12 , C07D263/58 , C07D267/14 , C07D277/30 , C07D277/36 , C07D295/13 , C07D295/15 , C07D513/04
摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
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公开(公告)号：EP2665701A2
公开(公告)日：2013-11-27
申请号：EP12736335.6
申请日：2012-01-12
IPC分类号： C07C245/04 , C07C243/06 , A61K31/04 , A61P9/12
CPC分类号： C07C291/02 , A61K45/06 , C07C291/08
摘要： A compound having the structure (I) useful for treating hypertension, pulmonary arterial hypertension, congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.
摘要翻译： 具有用于治疗高血压，肺动脉高压，充血性心力衰竭，由过度保水，心血管疾病，糖尿病，氧化应激，内皮功能障碍，肝硬化，先兆子痫，骨质疏松症或肾病引起的病症的结构（I）的化合物。
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公开(公告)号：EP2178537A1
公开(公告)日：2010-04-28
申请号：EP08780184.1
申请日：2008-07-15
发明人： DOBBELAAR, Peter, H. , DU, Wu , GUO, Liangqin , HAGMANN, William, K. , HE, Shuwen , JIAN, Tianying , LIU, Jian , NARGUND, Ravi, P. , PASTERNAK, Alexander , SHAH, Shrenik, K. , TRUONG, Quang, T. , YE, Zhixiong , DELLUREFICIO, James , BAKSHI, Raman
IPC分类号： A61K31/535
CPC分类号： C07D471/04
摘要： Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.
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公开(公告)号：EP2683687A1
公开(公告)日：2014-01-15
申请号：EP12709453.0
申请日：2012-03-05
发明人： SHAH, Shrenik, K. , ALI, Amjad , LO, Michael Man-Chu , WHITEHEAD, Brent , HENDERSON, Timothy, J. , YAN, Lin , GUO, Zhiqiang
IPC分类号： C07D207/12 , C07D207/48 , C07D211/46 , C07D211/96 , C07D223/08 , C07D309/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12 , C07D207/273 , A61K31/445
CPC分类号： C07D211/46 , C07D207/12 , C07D207/273 , C07D207/48 , C07D211/96 , C07D223/08 , C07D309/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12
摘要： A compound having the structure (I) useful for treating hypertension, Pulmonary Arterial Hypertension (PAH), congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.
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公开(公告)号：EP2523558A1
公开(公告)日：2012-11-21
申请号：EP11733256.9
申请日：2011-01-11
发明人： GUO, Liangqin , HAGMANN, William, K. , HE, Shuwen , LAI, Zhong , LIU, Jian , NARGUND, Ravi, P. , SHAH, Shrenik, K. , TRUONG, Quang, T.
IPC分类号： A01N43/42
CPC分类号： C07D471/04
摘要： Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.
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