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公开(公告)号：EP3083559A1
公开(公告)日：2016-10-26
申请号：EP14872226.7
申请日：2014-12-18
发明人： ANDRESEN, Brian M. , ARRINGTON, Kenneth L. , OTTE, Ryan D. , ELLIS, John Michael , BUTCHER, John W. , NORTHRUP, Alan B. , ROBICHAUD, Joel S. , GAUTHIER, Jacques Yves , FOURNIER, Jean-Francois
IPC分类号： C07D213/72
CPC分类号： C07D417/14 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D417/12
摘要： The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein ring R
1 , R
2 , R
3 , R
4 , ring B, and the subscript r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).摘要翻译： 本发明提供式（I）的某些噻唑取代的氨基杂芳基化合物或其药学上可接受的盐，其中R1，R2，R3，R4，环B和下标r如本文所定义。 本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）介导的疾病或病症的方法。
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公开(公告)号：EP2900665A1
公开(公告)日：2015-08-05
申请号：EP13841430.5
申请日：2013-09-24
发明人： MACHACEK, Michelle R. , ROMEO, Eric T. , KATTAR, Solomon D. , CHRISTOPHER, Matthew , ALTMAN, Michael D. , NORTHRUP, Alan B. , ELLIS, John Michael , BOYLE, Brendan O' , DONOFRIO, Anthony , GRIMM, Jonathan , REUTERSHAN, Michael H. , CHILDERS, Kaleen Konrad , OTTE, Ryan D. , CASH, Brandon , DUCHARME, Yves , HAIDLE, Andrew M. , SPENCER, Kerrie , VITHARANA, Dilrukshi , WU, Lingyun , ZHANG, Li , ZHANG, Peng , BEAULIEU, Christian , GUAY, Daniel
IPC分类号： C07D417/12 , C07D417/14 , C07D239/50 , A61K31/506 , A61P11/06 , A61P29/00 , A61P35/00
CPC分类号： C07D401/14 , A61K9/0019 , A61K9/0073 , A61K9/0075 , A61K9/10 , A61K9/2027 , A61K9/4858 , C07D239/42 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/04
摘要： Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
摘要翻译： 提供了式I的三唑衍生物，它们是有效的脾酪氨酸激酶抑制剂和药物组合物。 三唑衍生物可用于治疗和预防由所述酶介导的疾病，如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：EP2513098A1
公开(公告)日：2012-10-24
申请号：EP10801736.9
申请日：2010-12-15
发明人： ALTMANN, Michael D. , ANDRESEN, Brian M. , ARRINGTON, Kenneth L. , CHILDERS, Kaleen Konrad , DI FRANCESCO, Maria Emilia , DONOFRIO, Anthony , ELLIS, John Michael , FISCHER, Christian , GUERIN, David Joseph , HAIDLE, Andrew M. , KATTAR, Solomon , KNOWLES, Sandra Lee , LI, Chaomin , LIM, Jongwon , MACHACEK, Michelle , NORTHRUP, Alan B. , O'BOYLE, Brendan M. , OTTE, Ryan D. , PETROCCHI, Alessia , REUTERSHAN, Michael H. , ROMEO, Eric , SIU, Tony , TAOKA, Brandon M. , TROTTER, B. Wesley , ZHOU, Hua , BURCH, Jason , COTE, Bernard , DUPONT-GAUDET, Kristina , FOURNIER, Jean-Francois , GAUTHIER, Jacques Yves , GUAY, Daniel , ROBICHAUD, Joel S. , GRIMM, Jonathan , MADDESS, Matthew L. , SCHELL, Adam J. , SPENCER, Kerrie B. , WOO, Hyun Chong , BHAT, Sathesh
IPC分类号： C07D417/12 , C07D417/14 , A61K31/497 , A61P11/00 , A61P11/06 , A61P29/00 , A61P35/00
CPC分类号： C07D417/12 , C07D417/14 , C07D451/06 , C07D471/04 , C07D471/08 , C07D487/04 , C07D491/08 , C07D495/04 , C07F9/65583
摘要： The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
摘要翻译： 本发明提供了式（I）的新型嘧啶胺，它们是脾酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD和类风湿性关节炎。
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公开(公告)号：EP2934525B1
公开(公告)日：2019-05-08
申请号：EP13864370.5
申请日：2013-12-19
发明人： ALTMAN, Michael D. , ANDRESEN, Brian M. , ARRINGTON, Kenneth L. , CHILDERS, Kaleen Konrad , DI FRANCESCO, Maria Emilia , ELLIS, John Michael , HAIDLE, Andrew M. , LIU, Yuan , NORTHRUP, Alan , O'BOYLE, Brendan , OTTE, Ryan D. , REUTERSHAN, Michael H. , VITHARANA, Dilrukshi , WOO, Hyun Chong
IPC分类号： A61K31/44 , A61P35/00 , C07D417/14
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公开(公告)号：EP2706853A1
公开(公告)日：2014-03-19
申请号：EP12782298.9
申请日：2012-05-04
发明人： ALTMAN, Michael D. , CHILDERS, Kaleen Konrad , DI FRANCESCO, Maria Emilia , ELLIS, John Michael , FISCHER, Christian , GRIMM, Jonathan , HAIDLE, Andrew M. , KATTAR, Solomon D. , NORTHRUP, Alan B. , OTTE, Ryan D. , PETROCCHI, Alessia , SCHELL, Adam J. , ZHOU, Hua
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D417/12 , C07D417/14
摘要： The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.
摘要翻译： 本发明提供了式I的新型嘧啶胺，它们是有效的脾酪氨酸激酶抑制剂，可用于治疗和预防由所述酶介导的疾病，如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：EP2900665B1
公开(公告)日：2018-01-03
申请号：EP13841430.5
申请日：2013-09-24
发明人： MACHACEK, Michelle R. , ROMEO, Eric T. , KATTAR, Solomon D. , CHRISTOPHER, Matthew , ALTMAN, Michael D. , NORTHRUP, Alan B. , ELLIS, John Michael , BOYLE, Brendan O' , DONOFRIO, Anthony , GRIMM, Jonathan , REUTERSHAN, Michael H. , CHILDERS, Kaleen Konrad , OTTE, Ryan D. , CASH, Brandon , DUCHARME, Yves , HAIDLE, Andrew M. , SPENCER, Kerrie , VITHARANA, Dilrukshi , WU, Lingyun , ZHANG, Li , ZHANG, Peng , BEAULIEU, Christian , GUAY, Daniel
IPC分类号： C07D417/12 , C07D417/14 , C07D239/50 , A61K31/506 , A61P11/06 , A61P29/00 , A61P35/00
CPC分类号： C07D401/14 , A61K9/0019 , A61K9/0073 , A61K9/0075 , A61K9/10 , A61K9/2027 , A61K9/4858 , C07D239/42 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/04
摘要： Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
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公开(公告)号：EP2706853B1
公开(公告)日：2017-06-14
申请号：EP12782298.9
申请日：2012-05-04
发明人： ALTMAN, Michael D. , CHILDERS, Kaleen Konrad , DI FRANCESCO, Maria Emilia , ELLIS, John Michael , FISCHER, Christian , GRIMM, Jonathan , HAIDLE, Andrew M. , KATTAR, Solomon D. , NORTHRUP, Alan B. , OTTE, Ryan D. , PETROCCHI, Alessia , SCHELL, Adam J. , ZHOU, Hua
IPC分类号： A01N43/54 , A61K31/505 , C07D417/12 , A61K31/506 , A61P11/06 , A61P35/00 , C07D417/14
CPC分类号： C07D417/12 , C07D417/14
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公开(公告)号：EP2513098B1
公开(公告)日：2016-11-09
申请号：EP10801736.9
申请日：2010-12-15
发明人： ALTMANN, Michael D. , ANDRESEN, Brian M. , ARRINGTON, Kenneth L. , CHILDERS, Kaleen Konrad , DI FRANCESCO, Maria Emilia , DONOFRIO, Anthony , ELLIS, John Michael , FISCHER, Christian , GUERIN, David Joseph , HAIDLE, Andrew M. , KATTAR, Solomon , KNOWLES, Sandra Lee , LI, Chaomin , LIM, Jongwon , MACHACEK, Michelle , NORTHRUP, Alan B. , O'BOYLE, Brendan M. , OTTE, Ryan D. , PETROCCHI, Alessia , REUTERSHAN, Michael H. , ROMEO, Eric , SIU, Tony , TAOKA, Brandon M. , TROTTER, B. Wesley , ZHOU, Hua , BURCH, Jason , COTE, Bernard , DUPONT-GAUDET, Kristina , FOURNIER, Jean-Francois , GAUTHIER, Jacques Yves , GUAY, Daniel , ROBICHAUD, Joel S. , GRIMM, Jonathan , MADDESS, Matthew L. , SCHELL, Adam J. , SPENCER, Kerrie B. , WOO, Hyun Chong , BHAT, Sathesh
IPC分类号： C07D417/12 , C07D417/14 , A61K31/497 , A61P11/00 , A61P11/06 , A61P29/00 , A61P35/00
CPC分类号： C07D417/12 , C07D417/14 , C07D451/06 , C07D471/04 , C07D471/08 , C07D487/04 , C07D491/08 , C07D495/04 , C07F9/65583
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公开(公告)号：EP3116506B1
公开(公告)日：2019-04-17
申请号：EP15761538.6
申请日：2015-03-09
发明人： ALTMAN, Michael D. , CASH, Brandon , ELLIS, John Michael , MADDESS, Matthew L. , NORTHRUP, Alan B. , OTTE, Ryan D. , SUN, Binyuan
IPC分类号： A61K31/506 , A61K31/505 , C07D401/14 , C07D405/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D409/14 , C07D471/04 , C07D491/056 , A61K31/497 , A61K45/06
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公开(公告)号：EP3116506A1
公开(公告)日：2017-01-18
申请号：EP15761538.6
申请日：2015-03-09
发明人： ALTMAN, Michael D. , CASH, Brandon , ELLIS, John Michael , MADDESS, Matthew L. , NORTHRUP, Alan B. , OTTE, Ryan D. , SUN, Binyuan
IPC分类号： A61K31/506 , A61K31/505
CPC分类号： A61K31/497 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D491/056 , A61K2300/00
摘要： The invention provides certain pyrazine-2-carboxamide compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein A, B, and X are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
摘要翻译： 本发明提供了一些式（I）的吡嗪-2-甲酰胺化合物或其药学上可接受的盐，其中A，B和X如本文所定义。 本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）介导的疾病或病症的方法。
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