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    CRYSTALLINE ANTI-HUMAN IL-23 ANTIBODIES
    7.
    发明公开
    CRYSTALLINE ANTI-HUMAN IL-23 ANTIBODIES 审中-公开
    结晶抗体与人IL-23

    公开(公告)号：EP2866833A2

    公开(公告)日：2015-05-06

    申请号：EP13808570.9

    申请日：2013-06-25

    申请人： Merck Sharp & Dohme Corp.

    发明人： REICHERT, Paul ,  PROSISE, Winifred, W. ,  ORTH, Peter ,  NARASIMHAN, Chakravarthy ,  KASHI, Ramesh, S.

    IPC分类号： A61K39/395

    CPC分类号： C07K16/244 ,  A61K39/39591 ,  C07K2299/00 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

    摘要： Crystalline forms of antibodies to human IL-23, such as antibodies to human IL-23p19 , are provided, as well as methods of producing such crystalline forms, and uses of such crystalline forms, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders. In various embodiments, the anti-hulL-23 antibody crystals, such as anti-hulL-23p19 antibody crystals of the present invention are obtainable by batch crystallization methods, vapor diffusion methods, liquid-liquid diffusion methods, and dialysis. In other aspects, the invention relates to suspensions of the crystalline anti-hulL-23 antibodies of the present invention, including those at higher concentrations and lower viscosities than would be possible with a corresponding non-crystalline solution at the same concentration of antibody. In other embodiments, the anti-huiL-23 antibody crystals of the present invention have increased stability, i.e. they maintain biological activity of the anti-huiL-23 antibody, such as anti-huiL-23p 19 antibody, longer than corresponding solution formulations.