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公开(公告)号：EP1976849B1
公开(公告)日：2016-03-09
申请号：EP07709799.6
申请日：2007-01-16
发明人： YU, Wensheng , TONG, Ling , CHEN, Lei , KOZLOWSKI, Joseph, A. , LAVEY, Brian, J. , SHIH, Neng-Yang , MADISON, Vincent, S. , ZHOU, Guowei , ORTH, Peter , GUO, Zhuyan , WONG, Michael, K.C. , YANG, De-Yi , KIM, Seong-Heon , SHANKAR, Bandarpalle, B. , SIDDIQUI, M., Arshad , ROSNER, Kristin, E. , DAI, Chaoyang , POPOVICI-MULLER, Janeta , GIRIJAVALLABHAN, Vinay, M. , LI, Dansu , RIZVI, Razia , MICULA, Aneta, S , FELTZ, Robert Schering-Plough Corporation
IPC分类号： C07D401/14 , C07D403/06 , A61P35/00 , A61K31/4166 , C07D471/04 , C07D473/34 , C07D473/00 , C07D491/04 , C07D495/04 , C07D417/14 , C07D413/14 , C07D405/14 , C07D403/14
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
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公开(公告)号：EP2608669A1
公开(公告)日：2013-07-03
申请号：EP11820438.7
申请日：2011-08-22
发明人： ZHAO, Lianyun , LIU, Duan , TANG, Shuyi , MANDAL, Amit, K. , MANSOOR, Umar, Faruk , VITHARANA, Lalanthi, Dilrukshi , REDDY, Panduranga, Adulla, P. , SIDDIQUI, M., Arshad
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K45/06
摘要： The present invention relates to certain pyrazolo[1,5-a]pyrimidine compounds of Formula (I) as inhibitors of mammalian Target Of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP. The compounds may be used in the treatment of cancer and other disorders where mTOR is deregulated. The present invention further provides pharmaceutical compositions comprising the pyrazolo[1,5-a]pyrimidine compounds.
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公开(公告)号：EP1973900B1
公开(公告)日：2017-04-05
申请号：EP07716637.9
申请日：2007-01-16
发明人： LAVEY, Brian, J. , KOZLOWSKI, Joseph, A. , ZHOU, Guowei , TONG, Ling , YU, Wensheng , WONG, Michael, K.C. , SHANKAR, Bandarpalle, B. , SHIH, Neng-Yang , SIDDIQUI, M., Arshad , ROSNER, Kristin, E. , DAI, Chaoyang , POPOVICI-MULLER, Janeta , GIRIJAVALLABHAN, Vinay, M. , LI, Dansu , MICULA, Aneta, M. , KIM, Seong-heon , YANG, De-yi , RIZVI, Razia
IPC分类号： C07D403/06 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D513/04 , A61K31/4178 , A61P29/00
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
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公开(公告)号：EP2078003B1
公开(公告)日：2017-03-08
申请号：EP07853013.6
申请日：2007-10-29
发明人： SHIPPS, Gerald, W., Jr. , CHENG, Cliff, C. , HUANG, Xiaohua , FISCHMANN, Thierry, O. , DUCA, Jose, S. , RICHARDS, Matthew , ZENG, Hongbo , SUN, Binyuan , REDDY, Panduranga, A. , WONG, Tzu, T. , TADIKONDA, Praveen, K. , SIDDIQUI, M., Arshad , LABROLI, Marc, M. , POKER, Cory , GUZI, Timothy, J.
IPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10 , A61K31/426 , A61K31/427 , A61P35/00
CPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10
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公开(公告)号：EP1973901B1
公开(公告)日：2014-12-17
申请号：EP07716634.6
申请日：2007-01-16
发明人： LAVEY, Brian, J. , KOZLOWSKI, Joseph, A. , ZHOU, Guowei , TONG, Ling , YU, Wensheng , WONG, Michael, K.C. , SHANKAR, Bandarpalle, B. , SHIH, Neng-Yang , SIDDIQUI, M., Arshad , ROSNER, Kristin, E. , DAI, Chaoyang , POPOVICI-MULLER, Janeta , GIRIJAVALLABHAN, Vinay, M. , LI, Dansu , RIZVI, Razia , CHEN, Lei , YANG, De-yi , FELTZ, Robert , KIM, Seong-heon
IPC分类号： C07D403/14 , A61K31/4178 , A61P29/00
CPC分类号： C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
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公开(公告)号：EP2417138B1
公开(公告)日：2019-11-27
申请号：EP10715010.4
申请日：2010-04-08
发明人： DENG, Yongqi , SUN, Binyuan , ZENG, Hongbo , RICHARDS, Matthew , SHIPPS, Gerald, W., Jr. , CHENG, Cliff, C. , ZHAO, Yinyan , MCRINER, Andrew , MENG, Zhaoyang , NAN, Yang , PATEL, Mehul, F. , WRONA, Iwona, E. , REDDY, Panduranga, Adulla , EKLOV, Brian, M. , TANG, Shuyi , LIU, Duan , MANDAL, Amit, K. , ZHAO, Lianyun , SIDDIQUI, M., Arshad
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61P35/00
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公开(公告)号：EP2608669B1
公开(公告)日：2016-06-22
申请号：EP11820438.7
申请日：2011-08-22
发明人： ZHAO, Lianyun , LIU, Duan , TANG, Shuyi , MANDAL, Amit, K. , MANSOOR, Umar, Faruk , VITHARANA, Lalanthi, Dilrukshi , REDDY, Panduranga, Adulla, P. , SIDDIQUI, M., Arshad
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K45/06
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公开(公告)号：EP2069348B1
公开(公告)日：2015-12-30
申请号：EP07839217.2
申请日：2007-10-02
发明人： GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , SIDDIQUI, M., Arshad , REDDY, Panduranga, Adulla, P. , BELANGER, David, B. , HAMANN, Blake , CURRAN, Patrick, J.
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
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公开(公告)号：EP2078004B1
公开(公告)日：2015-02-25
申请号：EP07853035.9
申请日：2007-10-29
发明人： SHIPPS, Gerald, W., Jr. , CHENG, Cliff, C. , HUANG, Xiaohua , FISCHMANN, Thierry, O. , DUCA, Jose, S. , RICHARDS, Matthew , ZENG, Hongbo , SUN, Binyuan , REDDY, Panduranga, A. , ZHAO, Lianyun , TANG, Shuyi , WONG, Tzu, T. , TADIKONDA, Praveen, K. , TORRES, Luis, E. , SIDDIQUI, M., Arshad , DWYER, Michael, P. , KEERTIKAR, Kartik, M. , GUZI, Timothy, J.
IPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , A61P35/00
CPC分类号： C07D277/56 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04 , A61K2300/00
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公开(公告)号：EP2448942B1
公开(公告)日：2014-09-24
申请号：EP10730016.2
申请日：2010-06-30
发明人： CHENG, Cliff, C. , ZENG, Hongbo , SHIPPS, Jr., Gerald, W. , DENG, Yongqi , MENG, Zhaoyang , ZHAO, Lianyun , NAN, Yang , SUN, Binyuan , LIU, Duan , REDDY, Panduranga, A. , SIDDIQUI, M., Arshad
IPC分类号： C07D487/14 , A61K31/519 , A61P35/00
CPC分类号： C07D487/14
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