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公开(公告)号：EP2078003B1
公开(公告)日：2017-03-08
申请号：EP07853013.6
申请日：2007-10-29
发明人： SHIPPS, Gerald, W., Jr. , CHENG, Cliff, C. , HUANG, Xiaohua , FISCHMANN, Thierry, O. , DUCA, Jose, S. , RICHARDS, Matthew , ZENG, Hongbo , SUN, Binyuan , REDDY, Panduranga, A. , WONG, Tzu, T. , TADIKONDA, Praveen, K. , SIDDIQUI, M., Arshad , LABROLI, Marc, M. , POKER, Cory , GUZI, Timothy, J.
IPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10 , A61K31/426 , A61K31/427 , A61P35/00
CPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/10
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公开(公告)号：EP2515908A2
公开(公告)日：2012-10-31
申请号：EP10843507.4
申请日：2010-12-20
IPC分类号： A61K31/497
CPC分类号： C07D403/12 , C07D239/42 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to 1,4-Substituted Piperazine Derivatives, compositions comprising one or more 1,4-Substituted Piperazine Derivatives, and methods of using the 1,4-Substituted Piperazine Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
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公开(公告)号：EP2078004B1
公开(公告)日：2015-02-25
申请号：EP07853035.9
申请日：2007-10-29
发明人： SHIPPS, Gerald, W., Jr. , CHENG, Cliff, C. , HUANG, Xiaohua , FISCHMANN, Thierry, O. , DUCA, Jose, S. , RICHARDS, Matthew , ZENG, Hongbo , SUN, Binyuan , REDDY, Panduranga, A. , ZHAO, Lianyun , TANG, Shuyi , WONG, Tzu, T. , TADIKONDA, Praveen, K. , TORRES, Luis, E. , SIDDIQUI, M., Arshad , DWYER, Michael, P. , KEERTIKAR, Kartik, M. , GUZI, Timothy, J.
IPC分类号： C07D277/56 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , A61P35/00
CPC分类号： C07D277/56 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04 , A61K2300/00
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公开(公告)号：EP2654748B1
公开(公告)日：2016-07-27
申请号：EP11849978.9
申请日：2011-12-16
发明人： SHIPPS, Gerald, W., JR. , HUANG, Xiaohua , DENG, Yongqi , ZHU, Liang , COOPER, Alan, B. , SUN, Binyuan , ACHAB, Abdelghani Abe , LO, Sie-Mun
IPC分类号： A61K31/416 , C07D231/56 , A61P35/00 , C07D401/04 , C07D471/04 , C07D401/14 , C07D403/14 , C07D417/04
CPC分类号： A61K31/4439 , A61K31/416 , A61K31/437 , A61K45/06 , C07D231/56 , C07D401/04 , C07D401/14 , C07D403/14 , C07D417/04 , C07D471/04 , A61K2300/00
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公开(公告)号：EP2654748A1
公开(公告)日：2013-10-30
申请号：EP11849978.9
申请日：2011-12-16
发明人： SHIPPS, Gerald, W., JR. , HUANG, Xiaohua , DENG, Yongqi , ZHU, Liang , COOPER, Alan, B. , SUN, Binyuan , ACHAB, Abdelghani Abe , LO, Sie-Mun
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： A61K31/4439 , A61K31/416 , A61K31/437 , A61K45/06 , C07D231/56 , C07D401/04 , C07D401/14 , C07D403/14 , C07D417/04 , C07D471/04 , A61K2300/00
摘要： The present invention provides a compound of the Formula I, or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R
1 , R
2 , R
3 , m and are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions that comprise the above compounds, and methods of treating cancer using the same.-
公开(公告)号：EP2584903A1
公开(公告)日：2013-05-01
申请号：EP11798821.2
申请日：2011-06-22
发明人： DENG, Yongqi , ZHU, Liang , SHIPPS, Gerald, W., Jr. , LO, Sie-Mun , SUN, Binyuan , HUANG, Xiaohua , BEINSTOCK, Corey , COOPER, Alan, B. , GAO, Xiaolei , YAO, Xin , ZHU, Hugh, Y. , KELLY, Joseph, M. , BOGA, Sobhana Babu , ALHASSAN, Abdul-Basit , TAGAT, Jayaram, R. , MANSOOR, Umar Faruk , WILSON, Kevin , O'BOYLE, Brendan, M. , DANIELS, Matthew , SCHELL, Adam , SILIPHAIVANH, Phieng , FISCHER, Christian
IPC分类号： A01N43/56 , C07D231/56 , C07D209/48 , C07D235/04
CPC分类号： C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/1804
摘要： The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
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公开(公告)号：EP2584903B1
公开(公告)日：2018-10-24
申请号：EP11798821.2
申请日：2011-06-22
发明人： DENG, Yongqi , ZHU, Liang , SHIPPS, Gerald, W., Jr. , LO, Sie-Mun , SUN, Binyuan , HUANG, Xiaohua , BEINSTOCK, Corey , COOPER, Alan, B. , GAO, Xiaolei , YAO, Xin , ZHU, Hugh, Y. , KELLY, Joseph, M. , BOGA, Sobhana Babu , ALHASSAN, Abdul-Basit , TAGAT, Jayaram, R. , MANSOOR, Umar Faruk , WILSON, Kevin , O'BOYLE, Brendan, M. , DANIELS, Matthew , SCHELL, Adam , SILIPHAIVANH, Phieng , FISCHER, Christian
IPC分类号： A01N43/56 , C07D231/56 , C07D209/48 , C07D235/04
CPC分类号： C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F7/1804
摘要： The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
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公开(公告)号：EP2225235B1
公开(公告)日：2017-09-06
申请号：EP08844930.1
申请日：2008-10-27
IPC分类号： C07D417/14 , A61K31/427 , A61P35/00
CPC分类号： C07D417/14
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公开(公告)号：EP2358716B1
公开(公告)日：2016-01-06
申请号：EP09752650.3
申请日：2009-11-10
发明人： SHIPPS, JR., Gerald, W. , CHENG, Cliff, C. , HUANG, Xiaohua , ACHAB, Abdelghani, Abe , ORTH, Peter , VOIGT, Johannes, H. , SOUCY, Kyle, Ann
IPC分类号： C07D487/04 , C07D519/00 , A61P3/00 , A61K31/519
CPC分类号： C07D487/04 , C07D519/00
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公开(公告)号：EP2078002B1
公开(公告)日：2013-08-28
申请号：EP07853011.0
申请日：2007-10-29
发明人： SHIPPS, Gerald, W., Jr. , CHENG, Cliff, C. , HUANG, Xiaohua , FISCHMANN, Thierry, O. , DUCA, Jose, S. , RICHARDS, Matthew
IPC分类号： C07D277/56 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/501 , A61K31/4427 , A61K31/427 , A61P35/00
CPC分类号： C07D277/56 , C07D417/12 , C07D417/14 , C07D471/04
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