公开(公告)号：EP3302484A1

公开(公告)日：2018-04-11

申请号：EP16804001.2

申请日：2016-05-24

申请人： Merck Sharp & Dohme Corp. ,  MSD R&D (China) Co., Ltd.

发明人： SHEN, Dong-Ming ,  DWYER, Michael, P. ,  SINZ, Christopher, J. ,  WANG, Deping ,  STACHEL, Shawn, J. ,  PAONE, Daniel, V. ,  FORSTER, Ashley ,  BERGER, Richard ,  SHIPE, William, D. ,  CHEN, Yili ,  QIAN, Yimin ,  XU, Shimin ,  HU, Chunmei ,  FU, Jianmin ,  GUO, Zhigang ,  LI, Haitang ,  BO, Yingjian

IPC分类号： A61K31/519 ,  A61P25/28 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28

摘要： The present invention is directed to 6-alkyl dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

公开(公告)号：EP3302484B1

公开(公告)日：2020-09-16

申请号：EP16804001.2

申请日：2016-05-24

申请人： Merck Sharp & Dohme Corp. ,  MSD R&D (China) Co., Ltd.

发明人： SHEN, Dong-Ming ,  DWYER, Michael, P. ,  SINZ, Christopher, J. ,  WANG, Deping ,  STACHEL, Shawn, J. ,  PAONE, Daniel, V. ,  FORSTER, Ashley ,  BERGER, Richard ,  SHIPE, William, D. ,  CHEN, Yili ,  QIAN, Yimin ,  XU, Shimin ,  HU, Chunmei ,  FU, Jianmin ,  GUO, Zhigang ,  LI, Haitang ,  BO, Yingjian

IPC分类号： A61K31/519 ,  A61P25/28 ,  C07D487/04

公开(公告)号：EP3319966B1

公开(公告)日：2020-01-29

申请号：EP16818525.4

申请日：2016-06-27

申请人： Merck Sharp & Dohme Corp.

发明人： STACHEL, Shawn, J. ,  SINZ, Christopher, J. ,  CHEN, Yili ,  WILSON, Jonathan, E. ,  DWYER, Michael, P. ,  PAONE, Daniel, V. ,  XU, Shimin

IPC分类号： C07D487/04 ,  A61P25/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/28 ,  A61K31/519 ,  A61K31/53

公开(公告)号：EP3319966A1

公开(公告)日：2018-05-16

申请号：EP16818525.4

申请日：2016-06-27

申请人： Merck Sharp & Dohme Corp.

发明人： STACHEL, Shawn, J. ,  SINZ, Christopher, J. ,  CHEN, Yili ,  WILSON, Jonathan, E. ,  DWYER, Michael, P. ,  PAONE, Daniel, V. ,  XU, Shimin

IPC分类号： C07D487/04 ,  A61K31/53 ,  C07D231/56 ,  C07D253/06 ,  C07D253/065 ,  C07D253/075

CPC分类号： C07D487/04 ,  A61P25/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/28

摘要： The present invention is directed to dihydropyrazolopyrimidinone compounds of formulas (I) and (II) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.