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1.发明公开
公开(公告)号：EP3302484A1
公开(公告)日：2018-04-11
申请号：EP16804001.2
申请日：2016-05-24
发明人： SHEN, Dong-Ming , DWYER, Michael, P. , SINZ, Christopher, J. , WANG, Deping , STACHEL, Shawn, J. , PAONE, Daniel, V. , FORSTER, Ashley , BERGER, Richard , SHIPE, William, D. , CHEN, Yili , QIAN, Yimin , XU, Shimin , HU, Chunmei , FU, Jianmin , GUO, Zhigang , LI, Haitang , BO, Yingjian
IPC分类号： A61K31/519 , A61P25/28 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28
摘要： The present invention is directed to 6-alkyl dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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公开(公告)号：EP3302486A1
公开(公告)日：2018-04-11
申请号：EP16804194.5
申请日：2016-05-31
发明人： SHEN, Dong-Ming , DWYER, Michael P. , SINZ, Christopher J. , WANG, Deping , STACHEL, Shawn , PAONE, Daniel V. , FORSTER, Ashley , BERGER, Richard , CHEN, Yili , QIAN, Yimin , XU, Shimin , HU, Chunmei
IPC分类号： A61K31/519 , A61P25/28 , C07D487/04
摘要： The present invention is directed to dihydropyrazolopyrimidinone compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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3.发明公开
公开(公告)号：EP3087060A1
公开(公告)日：2016-11-02
申请号：EP14873215.9
申请日：2014-12-17
发明人： SHEN, Dong-Ming , EGBERTSON, Melissa , BERGER, Richard , QIAN, XiaoXia , QIAN, Yimin , HARPER, Bart , YANG, Meng , GUO, Zack Zhi Qiang , RADA, Vanessa L. , WANG, Deping , CERNAK, Timothy A. , SINZ, Christopher J. , WANG, Ming , WILSON, Jonathan E. , XU, Shimin
IPC分类号： C07D239/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , A61K31/513 , A61P25/18 , A61P25/22 , A61P25/28
CPC分类号： C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D487/04
摘要： Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.
摘要翻译： 公开了式（I）的嘧啶羧酰胺化合物，其可用作治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统疾病，药物组合物及其用途的治疗剂。
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公开(公告)号：EP3302486B1
公开(公告)日：2020-09-30
申请号：EP16804194.5
申请日：2016-05-31
发明人： SHEN, Dong-Ming , DWYER, Michael P. , SINZ, Christopher J. , WANG, Deping , STACHEL, Shawn , PAONE, Daniel V. , FORSTER, Ashley , BERGER, Richard , CHEN, Yili , QIAN, Yimin , XU, Shimin , HU, Chunmei
IPC分类号： A61K31/519 , A61P25/28 , C07D487/04
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公开(公告)号：EP3302484B1
公开(公告)日：2020-09-16
申请号：EP16804001.2
申请日：2016-05-24
发明人： SHEN, Dong-Ming , DWYER, Michael, P. , SINZ, Christopher, J. , WANG, Deping , STACHEL, Shawn, J. , PAONE, Daniel, V. , FORSTER, Ashley , BERGER, Richard , SHIPE, William, D. , CHEN, Yili , QIAN, Yimin , XU, Shimin , HU, Chunmei , FU, Jianmin , GUO, Zhigang , LI, Haitang , BO, Yingjian
IPC分类号： A61K31/519 , A61P25/28 , C07D487/04
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公开(公告)号：EP3087060B1
公开(公告)日：2020-05-13
申请号：EP14873215.9
申请日：2014-12-17
发明人： SHEN, Dong-Ming , EGBERTSON, Melissa , BERGER, Richard , QIAN, XiaoXia , QIAN, Yimin , HARPER, Bart , YANG, Meng , GUO, Zack Zhi Qiang , RADA, Vanessa L. , WANG, Deping , CERNAK, Timothy A. , SINZ, Christopher J. , WANG, Ming , WILSON, Jonathan E. , XU, Shimin
IPC分类号： C07D239/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , A61K31/513 , A61P25/18 , A61P25/22 , A61P25/28
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公开(公告)号：EP2276756A1
公开(公告)日：2011-01-26
申请号：EP09726601.9
申请日：2009-04-02
发明人： BERGER, Richard , CHANG, Lehua , EDMONDSON, Scott, D. , GOBLE, Stephen, D. , HA, Sookhee, Nicole , KAR, Nam, Fung , KOPKA, Ihor, E. , LI, Bing , MORRIELLO, Gregori, J. , MOYES, Chris, R. , SHEN, Dong-Ming , WANG, Liping , ZHU, Cheng
IPC分类号： C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04 , C07D487/04 , A61P13/00 , A61K31/4178 , A61K31/506
CPC分类号： C07D487/04 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译： 本发明提供式（I）的化合物，其药物组合物及其在治疗或预防由β3-肾上腺素受体激活介导的疾病中的使用方法。
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8.发明公开
公开(公告)号：EP3475275A1
公开(公告)日：2019-05-01
申请号：EP17815984.4
申请日：2017-06-19
发明人： WALJI, Abbas , BERGER, Richard , STUMP, Craig, A. , SCHLEGEL, Kelly Ann, S. , MULHEARN, James, J. , GRESHOCK, Thomas, J. , WANG, Deping , FRALEY, Mark, E. , JONES, Kristen, G.
IPC分类号： C07D413/14 , A61K31/4245 , A61K31/444
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9.发明公开
公开(公告)号：EP3313852A1
公开(公告)日：2018-05-02
申请号：EP16815100.9
申请日：2016-06-20
发明人： MORRIELLO, Gregori J. , CHANG, Lehua , FORSTER, Ashley , CHEN, Yili , DWYER, Michael, P. , BERGER, Richard , WANG, Ming , NANDA, Kausik K. , BUNDA, Jaime L. , SHIPE, William D.
IPC分类号： C07D498/04 , C07D491/04 , C07D495/04
CPC分类号： C07D498/04 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/28 , C07D473/34 , C07D487/04
摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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公开(公告)号：EP2274296B1
公开(公告)日：2012-10-17
申请号：EP09726940.1
申请日：2009-03-23
发明人： BERGER, Richard , CHANG, Lehua , EDMONDSON, Scott, D. , GOBLE, Stephen, D. , HARPER, Bart , KAR, Nam, Fung , KOPKA, Ihor, E. , LI, Bing , MORRIELLO, Gregori, J. , MOYES, Chris, R. , SHEN, Dong-ming , WANG, Liping , WENDT, Harvey , ZHU, Cheng
IPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , A61K31/4406 , A61P13/10
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04 , C07D495/04
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