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1.发明公开
公开(公告)号：EP3393472A1
公开(公告)日：2018-10-31
申请号：EP16879916.1
申请日：2016-12-19
发明人： ACTON, John, J., III , BAO, Jianming , EGBERTSON, Melissa , GAO, Xiaolei , HARRISON, Scott T. , KNOWLES, Sandra L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert D., Jr. , MENG, Zhaoyang , RUDD, Michael, T. , SELYUTIN, Oleg , TELLERS, David, M. , TONG, Ling , WAI, Jenny Miu-Chun
IPC分类号： A61K31/4155 , C07D231/10
摘要： The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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2.发明授权
公开(公告)号：EP3393472B1
公开(公告)日：2020-08-12
申请号：EP16879916.1
申请日：2016-12-19
发明人： ACTON, John, J., III , BAO, Jianming , EGBERTSON, Melissa , GAO, Xiaolei , HARRISON, Scott T. , KNOWLES, Sandra L. , LI, Chunsing , LO, Michael Man-Chu , MAZZOLA, Robert D., Jr. , MENG, Zhaoyang , RUDD, Michael, T. , SELYUTIN, Oleg , TELLERS, David, M. , TONG, Ling , WAI, Jenny Miu-Chun
IPC分类号： A61K31/4155 , C07D231/10
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3.发明公开THIOPHENE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES 审中-公开取代四环噻吩和方法及其使用病毒疾病治疗
公开(公告)号：EP2945953A1
公开(公告)日：2015-11-25
申请号：EP13872073.5
申请日：2013-12-31
发明人： TONG, Ling , YU, Wensheng , KOZLOWSKI, Joseph A. , CHEN, Lei , SELYUTIN, Oleg , KIM, Seong Heon , DWYER, Michael , HU, Bin , ZHONG, Bin , WANG, Dahai , HAO, Jinglai , SHEN, Changmao , LEI, Zhixin , WANG, Weijun
IPC分类号： C07D498/04 , C07D409/14 , A61K31/5365 , A61P31/14
CPC分类号： C07D498/04 , A61K31/4985 , A61K31/5365 , A61K31/7056 , A61K31/7072 , A61K38/005 , A61K38/212 , A61K45/06 , C07D519/00 , Y02A50/385 , Y02A50/389 , A61K2300/00
摘要： Thiophene-substituted tetracyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2, R3, R4 and R5 are as defined herein. The compositions comprising at least one thiophene-substituted tetracyclic compound, and methods of using the thiophene-substituted tetracyclic compounds for treating or preventing HCV infection in a patient are also provided.
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公开(公告)号：EP2945952B1
公开(公告)日：2019-08-28
申请号：EP13871363.1
申请日：2013-12-31
发明人： YU, Wensheng , TONG, Ling , KOZLOWSKI, Joseph A. , SELYUTIN, Oleg , CHEN, Lei , KIM, Jae-Hun , SHA, Deyou , RIZVI, Razia , SHANKAR, Bandarpalle , HU, Bin , ZHONG, Bin , WANG, Dahai , HAO, Jinglai , WEI, Wei , JI, Tao , ZAN, Shuai
IPC分类号： C07D498/04 , C07D409/14 , A61K31/5365 , A61P31/14 , A61K45/06
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5.发明公开HETEROCYCLE-SUBSTITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES 审中-公开杂环取代的FOR USE四环CONNECTIONS及其方法进行病毒疾病治疗
公开(公告)号：EP2945952A1
公开(公告)日：2015-11-25
申请号：EP13871363.1
申请日：2013-12-31
发明人： YU, Wensheng , TONG, Ling , KOZLOWSKI, Joseph A. , SELYUTIN, Oleg , CHEN, Lei , KIM, Jae-Hun , SHA, Deyou , RIZVI, Razia , SHANKAR, Bandarpalle , HU, Bin , ZHONG, Bin , WANG, Dahai , HAO, Jinglai , WEI, Wei , JI, Tao , ZAN, Shuai
IPC分类号： C07D498/04 , C07D409/14 , A61K31/5365 , A61P31/14
CPC分类号： A61K31/5365 , A61K31/4985 , A61K31/7056 , A61K31/7072 , A61K45/06 , C07D498/04 , C07D513/04 , Y02A50/385 , Y02A50/389 , A61K2300/00
摘要： The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
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