公开(公告)号：EP2882754B1

公开(公告)日：2018-10-03

申请号：EP13748245.1

申请日：2013-08-06

Applicant: Merck Sharp & Dohme Corp. ,  Merck Canada Inc.

Inventor： BARA, Thomas ,  BHAT, Sathesh ,  BISWAS, Dipshika ,  BROCKUNIER, Linda ,  BURNETTE, Duane ,  CHACKALAMANNIL, Samuel ,  CHELIAH, Mariappan, V. ,  CHEN, Austin ,  CLASBY, Martin ,  COLANDREA, Vince, J. ,  GUO, Zhuyan ,  HAN, Yongxin ,  JAYNE, Charles ,  JOSIEN, Hubert ,  MARCANTONIO, Karen ,  MIAO, Shouwu ,  NEELAMKAVIL, Santhosh ,  PINTO, Patrick ,  RAJAGOPALAN, Murali ,  SHAH, Unmesh ,  VELAZQUEZ, Francisco ,  VENKATRAMAN, Srikanth ,  XIA, Yan

IPC: C07D491/22 ,  C07D419/00 ,  A61K45/06 ,  A61K31/343 ,  A61K31/407 ,  A61P1/16 ,  A61P31/14

CPC classification number: C07K5/08 ,  A61K38/06 ,  A61K45/06 ,  C07D419/00 ,  C07D491/22

Abstract: The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.

公开(公告)号：EP2882754A1

公开(公告)日：2015-06-17

申请号：EP13748245.1

申请日：2013-08-06

Applicant: Merck Sharp & Dohme Corp. ,  Merck Canada Inc.

Inventor： BARA, Thomas ,  BHAT, Sathesh ,  BISWAS, Dipshika ,  BROCKUNIER, Linda ,  BURNETTE, Duane ,  CHACKALAMANNIL, Samuel ,  CHELIAH, Mariappan, V. ,  CHEN, Austin ,  CLASBY, Martin ,  COLANDREA, Vince, J. ,  GUO, Zhuyan ,  HAN, Yongxin ,  JAYNE, Charles ,  JOSIEN, Hubert ,  MARCANTONIO, Karen ,  MIAO, Shouwu ,  NEELAMKAVIL, Santhosh ,  PINTO, Patrick ,  RAJAGOPALAN, Murali ,  SHAH, Unmesh ,  VELAZQUEZ, Francisco ,  VENKATRAMAN, Srikanth ,  XIA, Yan

IPC: C07D491/107 ,  A61K31/343 ,  A61K31/407 ,  A61P1/16 ,  A61P31/14

CPC classification number: C07K5/08 ,  A61K38/06 ,  A61K45/06 ,  C07D419/00 ,  C07D491/22

Abstract: The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.

Abstract translation: 本发明涉及含有螺环状的丙型肝炎病毒（HCV）NS3蛋白酶抑制剂，这些化合物的用途以及这些化合物的合成。

公开(公告)号：EP2780026A2

公开(公告)日：2014-09-24

申请号：EP12850713.4

申请日：2012-11-09

Applicant: Merck Sharp & Dohme Corp. ,  Merck Canada Inc. ,  Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L.

Inventor： RUDD, Michael, T. ,  MCCAULEY, John ,  LIVERTON, Nigel ,  GRISE-BARD, Christiane ,  BROUCHU, Marie-Christine ,  CHARRON, Sylvie ,  AULAKH, Virender ,  BACHAND, Benoit ,  BEAULIEU, Patrick ,  ZAGHDANE, Helmi ,  HAN, Yongxin ,  FERRARA, Marco ,  HARPER, Steven ,  SUMMA, Vincenzo ,  CHACKALAMANNIL, Samuel ,  VENKATRAMAN, Srikanth ,  SHAH, Unmesh ,  VELAZQUEZ, Francisco

IPC: A61K38/12

CPC classification number: C07K5/08 ,  A61K31/4745 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/7056 ,  A61K38/005 ,  A61K38/06 ,  A61K38/12 ,  A61K38/21 ,  C07K5/0804 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0821 ,  A61K2300/00

Abstract: The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

公开(公告)号：EP3463362A1

公开(公告)日：2019-04-10

申请号：EP17803324.7

申请日：2017-05-19

Applicant: Merck Sharp & Dohme Corp.

Inventor： ADAMS, Gregory, L. ,  COX, Jason, M. ,  DEBENHAM, John, S. ,  EDMONDSON, Scott ,  GILBERT, Eric, J. ,  GUO, Yan ,  JIANG, Yu ,  JOSIEN, Hubert ,  KIM, Hyunjin, M. ,  LAN, Ping ,  MIAO, Shouwu ,  PLUMMER, Christopher, W. ,  RAJAGOPALAN, Murali ,  SHAH, Unmesh ,  SUN, Zhongxiang ,  TRUONG, Quang, T. ,  UJJAINWALLA, Feroze ,  VELAZQUEZ, Francisco ,  VENKATRAMAN, Srikanth ,  SUZUKI, Takao ,  WANG, Nengxue

IPC: A61K31/472 ,  A61K31/4725 ,  A61P3/10 ,  C07D217/02

公开(公告)号：EP2064180B1

公开(公告)日：2016-07-13

申请号：EP07862998.7

申请日：2007-12-17

Applicant: Merck Sharp & Dohme Corp.

Inventor： CHEN, Kevin X. ,  VENKATRAMAN, Srikanth ,  NJOROGE, F., George ,  ROSENBLUM, Stuart B. ,  LESBURG, Charles A. ,  DUCA, Jose S. ,  SHIH, Neng-Yang ,  VELAZQUEZ, Francisco ,  ANILKUMAR, Gopinadhan N. ,  ZENG, Qingbei ,  KOZLOWSKI, Joseph A.

IPC: C07D209/60 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D471/04 ,  C07D491/04 ,  A61K31/407 ,  A61P31/12 ,  C07D401/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

CPC classification number: C07D491/04 ,  C07D401/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

公开(公告)号：EP2408761B1

公开(公告)日：2014-01-01

申请号：EP08795629.8

申请日：2008-08-27

Applicant: Merck Sharp & Dohme Corp.

Inventor： ANILKUMAR, Gopinadhan, N. ,  BENNETT, Frank ,  CHAN, Tin-Yau ,  CHEN, Kevin, X. ,  SANNIGRAHI, Mousumi ,  VELAZQUEZ, Francisco ,  VENKATRAMAN, Srikanth ,  ZENG, Qingbei ,  DUCA, Jose, S. ,  LESBURG, Charles, A. ,  KOZLOWSKI, Joseph, A. ,  NJOROGE, F., George ,  ROSENBLUM, Stuart, B. ,  SHIH, Neng-Yang

IPC: C07D401/04 ,  C07D403/04 ,  A61K31/513 ,  A61P31/12

CPC classification number: C07D403/04 ,  C07D401/04

公开(公告)号：EP2303893B1

公开(公告)日：2016-12-07

申请号：EP09763490.1

申请日：2009-06-10

Applicant: Merck Sharp & Dohme Corp.

Inventor： VENKATRAMAN, Srikanth ,  ANILKUMAR, Gopinadhan, N. ,  CHEN, Kevin, X. ,  VELAZQUEZ, Francisco ,  ZENG, Qingbei ,  LIU, Duan ,  JIANG, Yueheng ,  KOZLOWSKI, Joseph, A. ,  NJOROGE, F., George ,  ROSENBLUM, Stuart, B. ,  GAVALAS, Stephen, J. ,  PINTO, Patrick, A. ,  SELYUTIN, Oleg, B. ,  VIBULBHAN, Bancha

IPC: C07D491/048 ,  C07D519/00 ,  A61P31/14 ,  A61K31/4439 ,  A61K31/444

CPC classification number: C07D491/048 ,  C07D491/04 ,  C07D519/00

公开(公告)号：EP2600872A1

公开(公告)日：2013-06-12

申请号：EP11815098.6

申请日：2011-07-28

Applicant: Merck Sharp & Dohme Corp.

Inventor： MIESEL, Gay Lynn ,  VENKATRAMAN, Srikanth

IPC: A61K31/497

CPC classification number: A61K31/4985 ,  A61K31/497 ,  Y02A50/402 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481

Abstract: Disclosed are methods of treating microbial infections, comprising administering a compound of Formula (I) Formula I wherein R1, R2, R3 and R4 are defined herein.

Abstract translation: 公开了治疗微生物感染的方法，包括施用其中R 1，R 2，R 3和R 4如本文所定义的式（I）的化合物。