专利检索 ap:("Merck Sharp & Dohme Corp." OR "Merck Frosst Canada Ltd.") AND inv:"HUGHES, Gregory" 第 1 页

1.

发明公开
PROCESS FOR THE PREPARATION OF AN OREXIN RECEPTOR ANTAGONIST 有权
标题翻译：用于生产食欲素受体拮抗剂

公开(公告)号：EP2297135A1

公开(公告)日：2011-03-23

申请号：EP09751262.8

申请日：2009-05-18

申请人： Merck Sharp & Dohme Corp. , Merck Frosst Canada Ltd.

发明人： CAMPEAU, Louis-charles , HUGHES, Gregory , GAUVREAU, Danny , GIRARDIN-RONDEAU, Melina , MELLON, Christophe , MOORE, Jeffrey, C. , O'SHEA, Paul , QUELLET, Stephane, G. , CHUNG, John Y. L. , MALONEY, Kevin Matthew

IPC分类号： C07D401/12 , C07D401/14 , C07D233/96

CPC分类号： C07D401/14 , C07D233/96 , C07D401/12

摘要： The present invention is directed to processes for preparing a pyridyl piperidine compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.

2.

发明公开
PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS 有权
标题翻译：用于生产氨基环己基的醚化合物

公开(公告)号：EP2605772A2

公开(公告)日：2013-06-26

申请号：EP11818552.9

申请日：2011-08-08

申请人： Merck Sharp & Dohme Corp.

发明人： LIMANTO, John , BEUTNER, Gregory, L. , YIN, Jingjun , KLAPARS, Artis , ASHLEY, Eric, R. , STROTMAN, Hallena, R. , TRUPPO, Matthew, D. , CHUNG, Cheol, K. , HUGHES, Gregory , LIU, Zhijian , GRAU, Brendan , JANEY, Jacob

IPC分类号： A61K31/275

CPC分类号： C07D207/12 , C07C217/52 , C07D207/416 , C12P17/10

摘要： The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates.

3.

发明授权
PROCESS FOR THE PREPARATION OF AN OREXIN RECEPTOR ANTAGONIST 有权
标题翻译：用于生产食欲素受体拮抗剂

公开(公告)号：EP2297135B1

公开(公告)日：2015-06-17

申请号：EP09751262.8

申请日：2009-05-18

申请人： Merck Sharp & Dohme Corp. , Merck Canada Inc.

发明人： CAMPEAU, Louis-charles , HUGHES, Gregory , GAUVREAU, Danny , GIRARDIN-RONDEAU, Melina , MELLON, Christophe , MOORE, Jeffrey, C. , O'SHEA, Paul , QUELLET, Stephane, G. , CHUNG, John Y. L. , MALONEY, Kevin Matthew

IPC分类号： C07D401/12 , C07D401/14 , C07D233/96

CPC分类号： C07D401/14 , C07D233/96 , C07D401/12

4.

发明公开
IMMOBILIZED TRANSAMINASES AND PROCESS FOR MAKING AND USING IMMOBILIZED TRANSAMINASE 审中-公开
标题翻译：固定化转氨酶和方法生产和使用固定化转氨酶

公开(公告)号：EP2723763A1

公开(公告)日：2014-04-30

申请号：EP12801916.3

申请日：2012-06-18

申请人： Merck Sharp & Dohme Corp.

发明人： TRUPPO, Matthew, D. , JANEY, Jacob, M. , HUGHES, Gregory

IPC分类号： C07K14/00 , C12Q1/52

CPC分类号： C12N9/1096 , C12N11/08 , C12P13/001 , C12P17/182 , Y02P20/52

摘要： The invention is directed to immobilized transaminases and methods of making and using them.