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公开(公告)号：EP2348857B1
公开(公告)日：2016-02-24
申请号：EP09822430.6
申请日：2009-10-12
发明人： BOOKSER, Brett, C. , DANG, Qun , GIBSON, Tony, S. , JIANG, Hongjian , CHUNG, De Michael , BAO, Jianming , JIANG, Jinlong , KASSICK, Andy , KEKEC, Ahmet , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F., Anthony , SEBHAT, Iyassu , WILSON, David , WODKA, Dariusz
IPC分类号： C07F9/6506 , C07F9/6558 , C07F9/6571 , A61K31/415
CPC分类号： C07F9/65068 , C07F9/65583 , C07F9/657181
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公开(公告)号：EP1689383A2
公开(公告)日：2006-08-16
申请号：EP04811701.4
申请日：2004-11-19
IPC分类号： A61K31/28 , A61K31/445 , A61K31/435 , C07F9/06
CPC分类号： C07F9/4056 , C07F9/301 , C07F9/306 , C07F9/3808 , C07F9/3882 , C07F9/4006 , C07F9/4075 , C07F9/4407 , C07F9/4465 , C07F9/5728 , C07F9/582 , C07F9/588 , C07F9/65517 , C07F9/657181
摘要： The present invention relates to compounds of phosphonic acid containing T3 mimetics, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndromex and diabetes.
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公开(公告)号：EP3924343A1
公开(公告)日：2021-12-22
申请号：EP09792782.6
申请日：2009-09-21
发明人： BOOKSER, Brett, C. , DANG, Qun , GIBSON, Tony, S. , JIANG, Hongjian , CHUNG, De Michael , BAO, Jianming , JIANG, Jinlong , KASSICK, Andy , KEKEC, Ahmet , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F. Anthony , SEBHAT, Iyassu , WILSON, David , WODKA, Dariusz
IPC分类号： C07D235/26 , C07D235/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , A61K31/4184 , A61K31/4439 , A61P3/10
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4.发明授权
公开(公告)号：EP2362731B1
公开(公告)日：2016-04-06
申请号：EP09824027.8
申请日：2009-10-22
发明人： DANG, Qun , CHUNG, De Michael , GIBSON, Tony, S. , JIANG, Hongjian , CASHION, Daniel, K. , BAO, Jianming , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F. Anthony , SEBHAT, Iyassu , WODKA, Dariusz
IPC分类号： A61K31/366 , C07F9/6506 , C07F9/6574 , A61K31/415 , A61K31/397 , A61K31/4184 , A01N43/50 , A61K31/4412 , A61K45/06 , C07F9/6558
CPC分类号： C07F9/65068 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4412 , A61K45/06 , C07F9/65583 , C07F9/65742 , A61K2300/00
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5.发明公开
公开(公告)号：EP2362731A1
公开(公告)日：2011-09-07
申请号：EP09824027.8
申请日：2009-10-22
发明人： DANG, Qun , CHUNG, De Michael , GIBSON, Tony, S. , JIANG, Hongjian , CASHION, Daniel, K. , BAO, Jianming , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F. Anthony , SEBHAT, Iyassu , WODKA, Dariusz
IPC分类号： A01N43/50 , A61K31/415 , C07D243/08
CPC分类号： C07F9/65068 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4412 , A61K45/06 , C07F9/65583 , C07F9/65742 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK- activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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公开(公告)号：EP1891080A2
公开(公告)日：2008-02-27
申请号：EP06760469.4
申请日：2006-05-26
CPC分类号： C07F9/65517 , C07F9/3211 , C07F9/36 , C07F9/3808 , C07F9/3882 , C07F9/4006 , C07F9/4056 , C07F9/4075 , C07F9/4407 , C07F9/4426 , C07F9/4465 , C07F9/657181
摘要： The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.
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公开(公告)号：EP1890768A2
公开(公告)日：2008-02-27
申请号：EP06760470.2
申请日：2006-05-26
IPC分类号： A61P5/14
CPC分类号： C07F9/4808 , C07F9/301 , C07F9/306 , C07F9/3264 , C07F9/3282 , C07F9/3288 , C07F9/36 , C07F9/4056 , C07F9/4084 , C07F9/4087 , C07F9/5728 , C07F9/65515 , C07F9/65517 , C07F9/657172
摘要： The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.
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公开(公告)号：EP2352374B1
公开(公告)日：2014-09-24
申请号：EP09824011.2
申请日：2009-10-19
发明人： DANG, Qun , CHUNG, De Michael , GIBSON, Tony, S. , JIANG, Hongjian , CASHION, Daniel, K. , BAO, Jianming , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F., Anthony , SEBHAT, Iyassu , WODKA, Dariusz
IPC分类号： C07D235/26 , C07D235/28 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04 , A61K31/4184
CPC分类号： C07D235/28 , C07D235/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04
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公开(公告)号：EP1689383B1
公开(公告)日：2012-10-31
申请号：EP04811701.4
申请日：2004-11-19
IPC分类号： C07F9/30 , A61K31/28 , A61K31/445 , A61K31/435 , C07F9/06 , A61P5/18
CPC分类号： C07F9/4056 , C07F9/301 , C07F9/306 , C07F9/3808 , C07F9/3882 , C07F9/4006 , C07F9/4075 , C07F9/4407 , C07F9/4465 , C07F9/5728 , C07F9/582 , C07F9/588 , C07F9/65517 , C07F9/657181
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公开(公告)号：EP2352374A1
公开(公告)日：2011-08-10
申请号：EP09824011.2
申请日：2009-10-19
发明人： DANG, Qun , CHUNG, De Michael , GIBSON, Tony, S. , JIANG, Hongjian , CASHION, Daniel, K. , BAO, Jianming , LAN, Ping , LU, Huagang , MAKARA, Gergely, M. , ROMERO, F., Anthony , SEBHAT, Iyassu , WODKA, Dariusz
IPC分类号： A01N43/52
CPC分类号： C07D235/28 , C07D235/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的激活剂并且可用于治疗，预防和抑制由AMPK-活化的蛋白激酶介导的疾病。 本发明化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。
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