专利检索 ap:("Metabolex Inc.") AND inv:"WILSON, Maria, E." 第 1 页

1.

发明公开
HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权
标题翻译：杂环受体激动剂糖尿病和代谢疾病的治疗

公开(公告)号：EP2111107A2

公开(公告)日：2009-10-28

申请号：EP07869989.9

申请日：2007-12-27

申请人： Metabolex Inc.

发明人： CHEN, Xin , CHENG, Peng , CLEMENS, L., Edward , JOHNSON, Jeffrey, D. , MA, Jingyuan , MURPHY, Alison , NASHASHIBI, Imad , RABBAT, Christopher, J. , SONG, Jiangao , WILSON, Maria, E. , ZHU, Yan , ZHAO, Zuchun

IPC分类号： A01N43/40 , A61K31/445 , A61K31/497

CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14

摘要： The present disclosure provides 2,4-disubstituted thiazoles of the general structure shown below that are agonists of G-protein coupled receptor (IC-GPCR2). Also, provided are compositions comprising these compounds as well as methods for using these compounds in a variety of applications including diabetes and metabolic disorders.

2.

发明公开
OXYMETHYLENE ARYL COMPOUNDS AND USES THEREOF 有权
标题翻译：甲醛芳基化合物和用途

公开(公告)号：EP2280704A1

公开(公告)日：2011-02-09

申请号：EP09727673.7

申请日：2009-03-30

申请人： METABOLEX, INC.

发明人： WILSON, Maria, E. , JOHNSON, Jeffrey , CLEMENS, L., Edward , ZHAO, Zuchun , CHEN, Xin

IPC分类号： A61K31/401 , A61K31/4523 , A61K31/4985 , A61K31/506

CPC分类号： A61K45/06 , A61K31/401 , A61K31/4523 , A61K31/4985 , A61K31/506 , A61K2300/00

摘要： Use of oxymethylene aryl GPR119 agonists and DPP IV inhibitors for the treatment of diabetic diseases, including Type II diabetes and other diseases associated with poor glycemic control are provided.

3.

发明授权
HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权
标题翻译： HETEROZYKLISCHE REZEPTORAGONISTEN ZUR BEHANDLUNG VON DIABETES UND STOFFWECHSELKRANKHEITEN

公开(公告)号：EP2111107B1

公开(公告)日：2013-04-24

申请号：EP07869989.9

申请日：2007-12-27

申请人： Metabolex Inc.

发明人： CHEN, Xin , CHENG, Peng , CLEMENS, L., Edward , JOHNSON, Jeffrey, D. , MA, Jingyuan , MURPHY, Alison , NASHASHIBI, Imad , RABBAT, Christopher, J. , SONG, Jiangao , WILSON, Maria, E. , ZHU, Yan , ZHAO, Zuchun

IPC分类号： A01N43/40 , A61K31/445 , A61K31/497

CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14

摘要： The present disclosure provides 2,4-disubstituted thiazoles of the general structure shown below that are agonists of G-protein coupled receptor (IC-GPCR2). Also, provided are compositions comprising these compounds as well as methods for using these compounds in a variety of applications including diabetes and metabolic disorders.

摘要翻译： 提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。本发明的化合物是口服活性的。