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9 条记录 (耗时 0.018 秒)

    PROCESS FOR THE STEREOSELECTIVE PREPARATION OF (-)-HALOFENATE AND INTERMEDIATES THEREOF
    1.
    发明公开
    PROCESS FOR THE STEREOSELECTIVE PREPARATION OF (-)-HALOFENATE AND INTERMEDIATES THEREOF 有权
    操作法，STEREO选择性制备（ - ） - HALOFENAT及中间体

    公开(公告)号：EP1940387A1

    公开(公告)日：2008-07-09

    申请号：EP06815150.5

    申请日：2006-09-21

    申请人： METABOLEX, INC.

    发明人： ZHU, Yan ,  CHENG, Peng ,  CHEN, Xin ,  MA, Jingyuan ,  ZHAO, Zuchun

    IPC分类号： A61K31/40 ,  A61K31/5375 ,  A61K31/495 ,  A61K31/4025 ,  C07D207/06 ,  C07D265/30 ,  C07D241/04

    CPC分类号： C07D295/185

    摘要： The present invention provides a compounds the formula (IV): and methods for producing an α-(phenoxy)phenylacetic acid compound of the formula: wherein R1 is a member selected from the group consisting of: each R2 is a member independently selected from the group consisting of (C1- C4)alkyl, halo, (C1-C4)haloalkyl, amino, (C1-C4 aminoalkyl, amido, (C1- C4)amidoalkyl, (C1-C4)sulfonylalkyl, (C1-C4)sulfamylalkyl, (C1-C4)allcoxy, (C1- C4)heteroalkyl, carboxy and nitro; the subscript n is 1 when R1 has the formula (a) or (b) and 2 when R1 has the formula (c) or (d); the subscript m is an integer of from O to 3; * indicates a carbon which is enriched in one stereoisomeric configuration; and the wavy line indicates the point of attachment of R1; and compounds .

    MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
    2.
    发明公开
    MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION 审中-公开
    PPAR调节因子及其制造方法

    公开(公告)号：EP1776111A2

    公开(公告)日：2007-04-25

    申请号：EP05785499.4

    申请日：2005-08-12

    申请人： METABOLEX, INC.

    发明人： ZHU, Yan ,  MA, Jingyuan ,  CHENG, Peng ,  ZHAO, Zuchun ,  GREGOIRE, Francine, M. ,  RAKHMANOVA, Vera, A.

    IPC分类号： A61K31/4192

    CPC分类号： C07D263/57 ,  C07D249/06 ,  C07D249/20 ,  C07D403/12 ,  C07D409/10

    摘要： The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.

    SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
    9.
    发明公开
    SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION 审中-公开
    AS PPAR调节取代的三唑及其制造方法

    公开(公告)号：EP1751120A2

    公开(公告)日：2007-02-14

    申请号：EP05759611.6

    申请日：2005-05-24

    申请人： METABOLEX, INC.

    发明人： ZHU, Yan ,  MA, Jingyuan ,  CHENG, Peng ,  ZHAO, Zuchun ,  GREGOIRE, Francine M. ,  RAKHMANOVA, Vera A.

    IPC分类号： C07D249/06 ,  A01N43/647

    CPC分类号： C07D249/06 ,  C07D409/10

    摘要： The present invention is directed to certain novel triazole compounds represented by Formula: (I); and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.