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公开(公告)号：EP2350016A2
公开(公告)日：2011-08-03
申请号：EP09744008.5
申请日：2009-10-20
申请人： Metabolex Inc.
发明人： MA, Jingyuan , NOVACK, Aaron , NASHASHIBI, Imad , PHAM, Phuongly , RABBAT, Christopher J. , SONG, Jiangao , SHI, Dong Fang , ZHAO, Zuchun , CHOI, Yun-Jung , CHEN, Xin
IPC分类号： C07D231/12 , C07D233/64 , C07D249/06 , C07D261/08 , C07D263/32 , C07D277/24 , C07D285/06 , C07D307/42 , C07D333/16 , C07D409/04 , A61K31/41 , A61P3/10
CPC分类号： C07D231/12 , C07D233/64 , C07D249/06 , C07D261/08 , C07D263/32 , C07D277/24 , C07D285/06 , C07D307/42 , C07D333/16 , C07D409/04
摘要： Aryl GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
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2.发明公开N-AZACYCLIC SUBSTITUTED PYRROLE, IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES AS AGONISTS OF THE RUP3 OR GPR119 FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权N-取代的氮杂环吡咯，吡唑，咪唑，三唑和四唑小于或RUP3- GPR119激动剂糖尿病和代谢紊乱的治疗
公开(公告)号：EP2185544A2
公开(公告)日：2010-05-19
申请号：EP08826604.4
申请日：2008-07-10
申请人： Metabolex Inc.
发明人： MA, Jingyuan , RABBAT, Christopher J. , SONG, Jiangao , CHEN, Xin , NASHASHIBI, Imad , ZHAO, Zuchun , NOVACK, Aaron , SHI, Dong Fang , CHENG, Peng , ZHU, Yan , MURPHY, Alison
IPC分类号： C07D401/14 , C07D401/04 , C07D413/14 , C07D417/14 , A61K31/4439 , A61K31/506 , A61K31/454 , A61P3/10
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
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3.发明公开HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权杂环受体激动剂糖尿病和代谢疾病的治疗
公开(公告)号：EP2111107A2
公开(公告)日：2009-10-28
申请号：EP07869989.9
申请日：2007-12-27
申请人： Metabolex Inc.
发明人： CHEN, Xin , CHENG, Peng , CLEMENS, L., Edward , JOHNSON, Jeffrey, D. , MA, Jingyuan , MURPHY, Alison , NASHASHIBI, Imad , RABBAT, Christopher, J. , SONG, Jiangao , WILSON, Maria, E. , ZHU, Yan , ZHAO, Zuchun
IPC分类号： A01N43/40 , A61K31/445 , A61K31/497
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present disclosure provides 2,4-disubstituted thiazoles of the general structure shown below that are agonists of G-protein coupled receptor (IC-GPCR2). Also, provided are compositions comprising these compounds as well as methods for using these compounds in a variety of applications including diabetes and metabolic disorders.
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公开(公告)号：EP2367793A1
公开(公告)日：2011-09-28
申请号：EP09796212.0
申请日：2009-12-17
申请人： Metabolex Inc.
发明人： SHI, Dong Fang , SONG, Jiangao , MA, Jingyuan , NOVACK, Aaron , PHAM, Phuongly , NASHASHIBI, Imad , RABBAT, Christopher J. , CHEN, Xin
IPC分类号： C07D213/64 , C07D231/56 , C07D235/12 , C07D307/79 , C07D307/83 , C07D311/58 , C07D319/08 , C07D333/54 , C07D407/04 , A61K31/343 , A61P5/50
CPC分类号： C07D405/04 , C07D213/64 , C07D231/56 , C07D235/12 , C07D307/79 , C07D307/80 , C07D307/83 , C07D307/94 , C07D311/58 , C07D319/08 , C07D333/54 , C07D333/60 , C07D405/10 , C07D407/04 , C07D407/12
摘要： GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
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公开(公告)号：EP2303859A2
公开(公告)日：2011-04-06
申请号：EP09798422.3
申请日：2009-06-16
申请人： Metabolex Inc.
发明人： SONG, Jiangao , MA, Jingyuan , RABBAT, Christopher, J. , NASHASHIBI, Imad , CHEN, Xin , ZHAO, Zuchun
IPC分类号： C07D401/04 , C07D401/14 , A61P3/10 , A61K31/444
CPC分类号： C07D401/04 , C07D401/14
摘要： Aryl GPR119 agonists are provided. These compounds are useful for the treatment of diabetic diseases, including Type II diabetes and other diseases associated with poor glycemic control.
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公开(公告)号：EP2582674A1
公开(公告)日：2013-04-24
申请号：EP10731862.8
申请日：2010-06-16
申请人： Metabolex Inc.
发明人： SHI, Dong Fang , SONG, Jiangao , MA, Jingyuan , NOVACK, Aaron , PHAM, Phuongly , NASHASHIBI, Imad , RABBAT, Christopher J. , CHEN, Xin
IPC分类号： C07D213/64 , C07D231/56 , C07D235/12 , C07D307/79 , C07D307/83 , C07D311/58 , C07D319/08 , C07D333/54 , C07D407/04 , A61K31/343 , A61P5/50
CPC分类号： C07D213/64 , C07D231/56 , C07D235/12 , C07D307/79 , C07D307/83 , C07D311/58 , C07D319/08 , C07D333/54 , C07D407/04
摘要： GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
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7.发明授权HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权HETEROZYKLISCHE REZEPTORAGONISTEN ZUR BEHANDLUNG VON DIABETES UND STOFFWECHSELKRANKHEITEN
公开(公告)号：EP2111107B1
公开(公告)日：2013-04-24
申请号：EP07869989.9
申请日：2007-12-27
申请人： Metabolex Inc.
发明人： CHEN, Xin , CHENG, Peng , CLEMENS, L., Edward , JOHNSON, Jeffrey, D. , MA, Jingyuan , MURPHY, Alison , NASHASHIBI, Imad , RABBAT, Christopher, J. , SONG, Jiangao , WILSON, Maria, E. , ZHU, Yan , ZHAO, Zuchun
IPC分类号： A01N43/40 , A61K31/445 , A61K31/497
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present disclosure provides 2,4-disubstituted thiazoles of the general structure shown below that are agonists of G-protein coupled receptor (IC-GPCR2). Also, provided are compositions comprising these compounds as well as methods for using these compounds in a variety of applications including diabetes and metabolic disorders.
摘要翻译： 提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。 本发明的化合物是口服活性的。
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公开(公告)号：EP2367793B1
公开(公告)日：2013-03-27
申请号：EP09796212.0
申请日：2009-12-17
申请人： Metabolex Inc.
发明人： SHI, Dong Fang , SONG, Jiangao , MA, Jingyuan , NOVACK, Aaron , PHAM, Phuongly , NASHASHIBI, Imad , RABBAT, Christopher J. , CHEN, Xin
IPC分类号： C07D213/64 , C07D231/56 , C07D235/12 , C07D307/79 , C07D307/83 , C07D311/58 , C07D319/08 , C07D333/54 , C07D407/04 , A61K31/343 , A61P5/50
CPC分类号： C07D405/04 , C07D213/64 , C07D231/56 , C07D235/12 , C07D307/79 , C07D307/80 , C07D307/83 , C07D307/94 , C07D311/58 , C07D319/08 , C07D333/54 , C07D333/60 , C07D405/10 , C07D407/04 , C07D407/12
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