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公开(公告)号：EP1461351A2
公开(公告)日：2004-09-29
申请号：EP02786860.3
申请日：2002-12-02
申请人： METABOLEX, INC.
CPC分类号： C07K14/47
摘要： Methods and Reagents for Diagnosis and Treatment of DiabetesThe invention relates to methods and reagents for diagnosing and treating diabetes.
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2.发明授权METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING DIABETES AND RELATED DISEASES INVOLVING BETA-TRP (MTR1 / LTRPC5 / TRPM5) 有权用于与BETA-TRP的诊断与治疗糖尿病和相关疾病的方法和组合物（MTR1 / LTRPC5 / TRPM5）
公开(公告)号：EP1599732B1
公开(公告)日：2007-05-09
申请号：EP04717456.0
申请日：2004-03-04
申请人： Metabolex Inc.
CPC分类号： C07K14/705 , A61K48/00 , G01N33/507 , G01N33/5088 , G01N33/6872 , G01N33/74 , G01N2333/62
摘要： Expression of beta-TRP is enriched in islet cells. Introduction of expression cassettes encoding beta-TRP into diabetic islet cells improved glucose-stimulated insulin production. Therefore, the invention provides methods of identifying beta-TRP modulators for treating diabetic individuals and introducing beta-TRP into islet cells.
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3.发明公开HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权杂环受体激动剂糖尿病和代谢疾病的治疗
公开(公告)号：EP2111107A2
公开(公告)日：2009-10-28
申请号：EP07869989.9
申请日：2007-12-27
申请人： Metabolex Inc.
发明人： CHEN, Xin , CHENG, Peng , CLEMENS, L., Edward , JOHNSON, Jeffrey, D. , MA, Jingyuan , MURPHY, Alison , NASHASHIBI, Imad , RABBAT, Christopher, J. , SONG, Jiangao , WILSON, Maria, E. , ZHU, Yan , ZHAO, Zuchun
IPC分类号： A01N43/40 , A61K31/445 , A61K31/497
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present disclosure provides 2,4-disubstituted thiazoles of the general structure shown below that are agonists of G-protein coupled receptor (IC-GPCR2). Also, provided are compositions comprising these compounds as well as methods for using these compounds in a variety of applications including diabetes and metabolic disorders.
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4.发明公开COMPOSITIONS AND METHODS OF USING APOPTOSIS SIGNALING KINASE RELATED KINASE (ASKRK) 审中-公开组合物之使用ASKRK方法（细胞凋亡信号激酶相关激酶）
公开(公告)号：EP1697542A2
公开(公告)日：2006-09-06
申请号：EP04810311.3
申请日：2004-11-03
申请人： METABOLEX, INC.
CPC分类号： C07K14/4747 , A61K38/00 , C12N9/12 , C12N9/1205 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The invention provides apoptosis signaling kinase related kinase (ASKRK) nucleic acid and polypeptide sequences and methods of using such sequences to identify modulators of ASKRK. Such modulators can be used for the treatment of diabetes or for delaying the onset of diabetes. The invention also provides methods of diagnosing diabetes or pre-diabetes and methods of making a prognosis based on the detection of ASKRK nucleic acids and proteins.
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公开(公告)号：EP1604036A2
公开(公告)日：2005-12-14
申请号：EP04757980.0
申请日：2004-03-19
申请人： METABOLEX, INC.
发明人： JOHNSON, Jeffrey, D. , GREGOIRE, Francine, M. , SCHWEITZER, Anthony , TERASAWA, Yuko , WILSON, Maria, S. , BLUME, John, E.
CPC分类号： G01N33/5008 , C12Q1/485 , G01N33/502 , G01N33/5023 , G01N33/5044 , G01N33/507 , G01N33/5088 , G01N33/5091 , G01N33/6893 , G01N2800/042
摘要： The current invention provides methods of identifying modulators of hexokinase V. Such modulators can be used for the treatment of diabetes or for delaying the onset of diabetes. The invention also provides methods of diagnosing diabetes or pre-diabetes and methods of making a prognosis based on the detection of hexokinase V nucleic acids and proteins.
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6.发明公开METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING DIABETES AND RELATED DISEASES INVOLVING BETA-TRP (MTR1 / LTRPC5 / TRPM5) 有权用于与BETA-TRP的诊断与治疗糖尿病和相关疾病的方法和组合物（MTR1 / LTRPC5 / TRPM5）
公开(公告)号：EP1599732A1
公开(公告)日：2005-11-30
申请号：EP04717456.0
申请日：2004-03-04
申请人： Metabolex Inc.
CPC分类号： C07K14/705 , A61K48/00 , G01N33/507 , G01N33/5088 , G01N33/6872 , G01N33/74 , G01N2333/62
摘要： Expression of beta-TRP is enriched in islet cells. Introduction of expression cassettes encoding beta-TRP into diabetic islet cells improved glucose-stimulated insulin production. Therefore, the invention provides methods of identifying beta-TRP modulators for treating diabetic individuals and introducing beta-TRP into islet cells.
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7.发明授权HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权HETEROZYKLISCHE REZEPTORAGONISTEN ZUR BEHANDLUNG VON DIABETES UND STOFFWECHSELKRANKHEITEN
公开(公告)号：EP2111107B1
公开(公告)日：2013-04-24
申请号：EP07869989.9
申请日：2007-12-27
申请人： Metabolex Inc.
发明人： CHEN, Xin , CHENG, Peng , CLEMENS, L., Edward , JOHNSON, Jeffrey, D. , MA, Jingyuan , MURPHY, Alison , NASHASHIBI, Imad , RABBAT, Christopher, J. , SONG, Jiangao , WILSON, Maria, E. , ZHU, Yan , ZHAO, Zuchun
IPC分类号： A01N43/40 , A61K31/445 , A61K31/497
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present disclosure provides 2,4-disubstituted thiazoles of the general structure shown below that are agonists of G-protein coupled receptor (IC-GPCR2). Also, provided are compositions comprising these compounds as well as methods for using these compounds in a variety of applications including diabetes and metabolic disorders.
摘要翻译： 提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。 本发明的化合物是口服活性的。
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公开(公告)号：EP1572085A3
公开(公告)日：2005-09-21
申请号：EP03737015.2
申请日：2003-06-10
申请人： METABOLEX, INC.
IPC分类号： A61K6/00
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公开(公告)号：EP1572085A2
公开(公告)日：2005-09-14
申请号：EP03737015.2
申请日：2003-06-10
申请人： METABOLEX, INC.
IPC分类号： A61K6/00
CPC分类号： G01N33/6872 , C07K14/705 , G01N2500/04 , G01N2500/10
摘要： The present invention provides polynucleotides encoding potassium channels as well as methods of using the potassium channels to treat and diagnose diabetes and a predisposion for diabetes.
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10.发明公开NUCLEIC ACIDS ENCODING A G-PROTEIN COUPLED RECEPTOR INVOLVED IN ISLET CELL SIGNALING 审中-公开A ON CELL SIGNALING是否涉及G蛋白偶联受体的核酸编码岛
公开(公告)号：EP1506306A2
公开(公告)日：2005-02-16
申请号：EP03710641.6
申请日：2003-01-06
申请人： METABOLEX, INC.
IPC分类号： C12Q1/00
CPC分类号： C07K14/705
摘要： The invention provides isolated nucleic acid and amino acid sequences of human and murine islet cell G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, methods of screening for modulators of islet cell G-protein coupled receptors and methods of treating mammals with modulators of islet cell G-protein coupled receptor activity.
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