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公开(公告)号：EP2933248A1
公开(公告)日：2015-10-21
申请号：EP13836321.3
申请日：2013-09-13
发明人： IIJIMA, Toru , TAKAHASHI, Yoichi , HIRAI, Miki , SUGAMA, Hiroshi , TOGASHI, Yuko , SHEN, Jingkang , XIA, Guangxin , WAN, Huixin
IPC分类号： C07D265/30 , A61K31/5377 , A61P9/04 , A61P9/12 , A61P13/12 , A61P43/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048
CPC分类号： C07D413/12 , C07D265/30 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048
摘要： The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I] which is useful as a renin inhibitor.
wherein R 1 is a cycloalkyl group or an alkyl,
R 22 is an optionally substituted aryl and the like,
R is a lower alkyl group,
R 3 , R 4 , R 5 and R 6 are the same or different, and are a hydrogen atom, an optionally substituted carbamoyl, an optionally substituted alkyl, or alkoxycarbonyl,
or a pharmaceutically acceptable salt thereof.摘要翻译： 本发明提供了可用作肾素抑制剂的式[I]的含氮饱和杂环化合物。 其中R 1为环烷基或烷基，R 22为任选取代的芳基等，R为低级烷基，R 3，R 4，R 5和R 6相同或不同，为氢 原子，任选取代的氨基甲酰基，任选取代的烷基或烷氧基羰基，或其药学上可接受的盐。
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公开(公告)号：EP2687518B1
公开(公告)日：2017-11-01
申请号：EP12757539.7
申请日：2012-03-15
发明人： IIJIMA, Toru , SUGAMA, Hiroshi , KAWAGUCHI, Takayuki , SHEN, Jingkang , XIA, Guangxin , XIE, Jianshu , HIRAI, Miki
IPC分类号： C07D265/30 , A61K31/4025 , A61K31/416 , A61K31/437 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61P9/00 , A61P9/12 , A61P13/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D471/04
CPC分类号： C07D265/30 , C07D231/56 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D471/04
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公开(公告)号：EP2687518A1
公开(公告)日：2014-01-22
申请号：EP12757539.7
申请日：2012-03-15
发明人： IIJIMA, Toru , SUGAMA, Hiroshi , KAWAGUCHI, Takayuki , SHEN, Jingkang , XIA, Guangxin , XIE, Jianshu
IPC分类号： C07D265/30 , A61K31/4025 , A61K31/416 , A61K31/437 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61P9/00 , A61P9/12 , A61P13/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D471/04
CPC分类号： C07D265/30 , C07D231/56 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D471/04
摘要： The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I]:
wherein R 1 is a cycloalkyl group and the like, R 22 is an optionally substituted aryl and the like, R is a lower alkyl and the like, T is a carbonyl group, Z is -O- and the like, and R 3 to R 6 are the same or different and a hydrogen atom and the like; or a pharmaceutically acceptable salt, that is useful as a renin inhibitor.摘要翻译： 本发明提供了式[I]的含氮饱和杂环化合物：其中R 1为环烷基等，R 22为任选取代的芳基等，R为低级烷基等，T为 羰基，Z是-O-等，R 3〜R 6相同或不同，表示氢原子等。 或可药用盐，其可用作肾素抑制剂。
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公开(公告)号：EP2168952B1
公开(公告)日：2017-02-15
申请号：EP08777242.2
申请日：2008-06-16
发明人： AKATSUKA, Hidenori , SUGAMA, Hiroshi , AWAI, Nobumasa , KAWAGUCHI, Takayuki , TAKAHASHI, Yoichi , IIJIMA, Toru , SHEN, Jingkang , XIA, Guangxin , XIE, Jianshu
IPC分类号： C07D265/30 , A61K31/5375 , A61K31/538 , A61P9/04 , A61P9/12 , A61P13/12 , A61P43/00 , C07D265/36 , C07D413/12
CPC分类号： C07D265/30 , C07D209/08 , C07D209/14 , C07D209/30 , C07D209/34 , C07D209/42 , C07D231/56 , C07D265/36 , C07D403/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
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公开(公告)号：EP2933248B1
公开(公告)日：2018-01-31
申请号：EP13836321.3
申请日：2013-09-13
发明人： IIJIMA, Toru , TAKAHASHI, Yoichi , HIRAI, Miki , SUGAMA, Hiroshi , TOGASHI, Yuko , SHEN, Jingkang , XIA, Guangxin , WAN, Huixin
IPC分类号： C07D265/30 , A61K31/5377 , A61P9/04 , A61P9/12 , A61P13/12 , A61P43/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048
CPC分类号： C07D413/12 , C07D265/30 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048
摘要： The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I] which is useful as a renin inhibitor. wherein R 1 is a cycloalkyl group or an alkyl, R 22 is an optionally substituted aryl and the like, R is a lower alkyl group, R 3 , R 4 , R 5 and R 6 are the same or different, and are a hydrogen atom, an optionally substituted carbamoyl, an optionally substituted alkyl, or alkoxycarbonyl, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP1907387A1
公开(公告)日：2008-04-09
申请号：EP06781142.2
申请日：2006-07-10
IPC分类号： C07D417/12 , C07D417/14 , C07D513/04 , C07D213/75 , C07D277/46 , C07D285/08 , C07D241/20 , C07D403/06 , C07D405/12 , C07D405/14 , A61K31/433 , A61P3/04 , A61P3/10 , A61P9/10 , C07C251/32
CPC分类号： C07D405/12 , A61K31/433 , C07D213/75 , C07D241/20 , C07D277/46 , C07D285/01 , C07D403/06 , C07D405/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]: wherein Ring A is aryl or heteroaryl; Q is cycloalkyl, heterocycle, alkyl or alkenyl; Ring T is heteroaryl or heterocycle; R1 and R2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl or the like; R3 and R4 are independently hydrogen atom, hydroxy, oxo, halogen atom or the like; R5 is hydrogen atom, halogen atom, cyano, nitro, tetrazolyl or the like; or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP4363406A1
公开(公告)日：2024-05-08
申请号：EP22744149.0
申请日：2022-07-01
发明人： JOHANSSON, Lars Anders Mikael , GRADÉN, Henrik , BERGONZINI, Giulia , SUGAMA, Hiroshi , MATSUMURA, Takehiko
IPC分类号： C07D237/34 , C07D471/04
CPC分类号： C07D471/04 , C07D237/34
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公开(公告)号：EP2168952A1
公开(公告)日：2010-03-31
申请号：EP08777242.2
申请日：2008-06-16
发明人： AKATSUKA, Hidenori , SUGAMA, Hiroshi , AWAI, Nobumasa , KAWAGUCHI, Takayuki , TAKAHASHI, Yoichi , IIJIMA, Toru , SHEN, Jingkang , XIA, Guangxin , XIE, Jianshu
IPC分类号： C07D265/30 , A61K31/5375 , A61K31/538 , A61P9/04 , A61P9/12 , A61P13/12 , A61P43/00 , C07D265/36 , C07D413/12
CPC分类号： C07D265/30 , C07D209/08 , C07D209/14 , C07D209/30 , C07D209/34 , C07D209/42 , C07D231/56 , C07D265/36 , C07D403/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention provides a morpholine derivative of the formula [I];
wherein R 1 is a substituted alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclo group, a cycloalkyl group or an alkyl group; R 2 is a substituted alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclo group, an optionally substituted alkylcarbonyl group, an optionally substituted arylcarbonyl group, an optionally substituted heterocyclo-substituted carbonyl group or a cycloalkylcarbonyl group; T is a methylene group or a carbonyl group; R 3 , R 4 , R 5 and R 6 are the same or different and a hydrogen atom, an optionally substituted carbamoyl group or an optionally substituted alkyl group;
or pharmaceutically acceptable salts thereof.
These compounds are useful as a renin inhibitor.摘要翻译： 本发明提供式[I]的吗啉衍生物; 其中R 1是取代的烷基，任选取代的芳基，任选取代的杂环基，环烷基或烷基; R 2是取代的烷基，任选取代的芳基，任选取代的杂环基，任选取代的烷基羰基，任选取代的芳基羰基，任选取代的杂环取代的羰基或环烷基羰基; T是亚甲基或羰基; R 3，R 4，R 5和R 6相同或不同，氢原子，任选取代的氨基甲酰基或任选取代的烷基; 或其药学上可接受的盐。 这些化合物可用作肾素抑制剂。
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公开(公告)号：EP2105435A1
公开(公告)日：2009-09-30
申请号：EP08703326.2
申请日：2008-01-09
IPC分类号： C07D213/75 , A61K31/422 , A61K31/427 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/455 , A61K31/497 , A61K31/4995 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P27/02 , A61P43/00
CPC分类号： C07D213/75 , C07D213/80 , C07D239/42 , C07D239/72 , C07D241/20 , C07D261/14 , C07D277/20 , C07D277/46 , C07D277/56 , C07D285/08 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D487/08 , C07D498/04 , C07D513/04
摘要： A hydrazone derivative of formula [I]:
wherein Ring A is aryl or heteroaryl, Ring T is heteroaryl or heterocycle, R 1 and R 2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl, etc., R 3 and R 4 combine each other together with the adjacent nitrogen atom to form substituted or unsubstituted heterocycle, R 5 is hydrogen atom, halogen atom, cyano, nitro, tetrazolyl, etc., and R 6 is hydrogen atom, etc.; or a pharmaceutically acceptable salt thereof is useful as a gluokinase activation agent.摘要翻译： 式[I]的腙衍生物：其中环A是芳基或杂芳基，环T是杂芳基或杂环，R 1和R 2独立地是氢原子，卤素原子，环烷基磺酰基等，R 3和R 4相互结合 与相邻的氮原子一起形成取代或未取代的杂环，R 5为氢原子，卤素原子，氰基，硝基，四唑基等，R 6为氢原子等。 或其药学上可接受的盐可用作葡萄糖激酶活化剂。
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