公开(公告)号：EP4368184A3

公开(公告)日：2024-07-31

申请号：EP24166495.2

申请日：2020-11-19

申请人： Modag GmbH ,  Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： GIESE, Armin ,  SCHMIDT, Felix ,  WECKBECKER, Daniel ,  LEONOV, Andrei ,  RYAZANOV, Sergey ,  GRIESINGER, Christian ,  PICHLER, Bernd ,  HERFERT, Kristina ,  MAURER, Andreas ,  KÜBLER, Laura ,  BUSS, Sabrina

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  A61P25/16 ,  A61P25/28 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  A61P25/16 ,  A61P25/28

摘要： The present invention relates to a compound represented by the general formula Ila or IIb

or a solvate or salt thereof, wherein

is selected from

and

is selected from

Y1, Y2, Y3, Y4, Y5, Y6, Y7 and Y8 are independently selected from CR3 and N, with the proviso that at least one of Y1, Y2, Y3, Y4, Y5, Y6, Y7 and Y8 is N and with the proviso that in the formulae la or Ib, at least one of Y1, Y3, Y4, and Y6 is N; R1 is independently selected from hydrogen, C1-4 alkyl and -(CH2)-O-P(=O)(OR)(OR), wherein C1-4 alkyl can be optionally substituted by one or more halogen; R2 is independently selected from hydrogen, halogen, and C1-4 alkyl, wherein C1-4 alkyl can be optionally substituted by one or more halogen; R is hydrogen or a cation; R3 is hydrogen; R4 and R5 are independently selected from H and C1-4 alkyl, wherein C1-4 alkyl can be optionally substituted by one or more halogen or wherein R4 and R5 together with the nitrogen atom to which they are bound form a piperazinyl ring which is substituted by one or more R6; and R6 is independently selected from halogen, C1-4 alkyl, OH and C1-4 alkoxy, wherein C1-4 alkyl and C1-4 alkoxy can be optionally substituted by one or more halogen; and Hal is halogen.

公开(公告)号：EP4061807A1

公开(公告)日：2022-09-28

申请号：EP20810960.3

申请日：2020-11-19

申请人： Modag GmbH ,  Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： GIESE, Armin ,  SCHMIDT, Felix ,  WECKBECKER, Daniel ,  LEONOV, Andrei ,  RYAZANOV, Sergey ,  GRIESINGER, Christian ,  PICHLER, Bernd ,  HERFERT, Kristina ,  MAURER, Andreas ,  KÜBLER, Laura ,  BUSS, Sabrina

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  A61P25/16 ,  A61P25/28 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506

公开(公告)号：EP2307381A2

公开(公告)日：2011-04-13

申请号：EP09772072.6

申请日：2009-06-09

申请人： Ludwig-Maximilians-Universität München ,  Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： GIESE, Armin ,  BERTSCH, Uwe ,  KRETZSCHMAR, Hans ,  HABECK, Mathias ,  HIRSCHBERGER, Thomas ,  TAVAN, Paul ,  GRIESINGER, Christian ,  LEONOV, Andrei ,  RYAZANOV, Sergey ,  WEBER, Petra ,  GEISSEN, Markus ,  GROSCHUP, Martin, H. ,  WAGNER, Jens

IPC分类号： C07D231/06 ,  C07D231/12 ,  C07D233/22 ,  C07D261/08 ,  C07D271/06

CPC分类号： C07D231/12 ,  A61K31/40 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4164 ,  A61K31/42 ,  A61K31/4245 ,  C07D207/333 ,  C07D231/06 ,  C07D233/64 ,  C07D261/08 ,  C07D271/06 ,  C07D405/04 ,  C07D413/04 ,  G01N33/6896 ,  G01N2800/2828

摘要： The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed.

摘要翻译： 本发明涉及由式（E）表示的化合物。 因此，本发明涉及用于治疗或预防与蛋白聚集和/或神经变性疾病的疾病使用由式（E）表示的化合物。 更过地，本发明涉及药物和诊断组合物包括本发明的化合物以及一种试剂盒。 进一步地，本发明涉及聚集蛋白的成像沉积物的方法。 因此，一种制备本发明的可检测标记的化合物的试剂盒是游离缺失盘。

公开(公告)号：EP3634403A1

公开(公告)日：2020-04-15

申请号：EP18722077.7

申请日：2018-05-11

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. ,  Ludwig-Maximilians-Universität München ,  Georg-August-Universität Göttingen

发明人： BECKER, Dorothea ,  JOVIN, Thomas M. ,  GRIESINGER, Christian ,  LEONOV, Andrei ,  RYAZANOV, Sergey ,  GIESE, Armin ,  OUTEIRO, Tiago F. ,  LAZARO, Diana F. ,  SCHÖN, Michael P. ,  SCHÖN, Margarete

IPC分类号： A61K31/415 ,  A61K31/4155 ,  A61K31/675 ,  A61P35/00

公开(公告)号：EP4384013A1

公开(公告)日：2024-06-19

申请号：EP22812543.1

申请日：2022-10-27

申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

发明人： GRIESINGER, Christian ,  RUHE, Jonas ,  RYAZANOV, Sergey ,  KEMEN, Eric ,  LEONOV, Andrei

IPC分类号： A01N43/56 ,  A01N43/50 ,  A01N43/653 ,  A01N43/76 ,  A01N43/80 ,  A01N43/82 ,  A01P1/00 ,  A01P3/00 ,  C07D231/12 ,  C07D233/58 ,  C07D249/08 ,  C07D261/08 ,  C07D263/32 ,  C07D271/06 ,  C07D233/64 ,  C07D405/04 ,  C07D413/04

CPC分类号： A01N43/56 ,  A01N43/50 ,  A01N43/80 ,  A01N43/76 ,  A01N43/82 ,  A01N43/653 ,  C07D231/12 ,  C07D261/08 ,  C07D263/32 ,  C07D271/06 ,  C07D249/08 ,  C07D233/64 ,  C07D413/04 ,  C07D405/04