公开(公告)号：EP1438590A1

公开(公告)日：2004-07-21

申请号：EP02789229.8

申请日：2002-10-21

Applicant: MonoGen, Inc.

Inventor： PRESSMAN, Norman, J. ,  WROBLEWSKI, Lucien, J.

IPC: G01N35/02

CPC classification number: G01N1/4077 ,  B01D61/18 ,  B01D61/22 ,  B01D63/08 ,  B01D65/08 ,  B01D2321/02 ,  B01D2321/10 ,  B01D2321/16 ,  B01D2321/2008 ,  B01D2321/2016 ,  B01D2321/2066 ,  B01F7/00583 ,  B01F7/1695 ,  B01F13/002 ,  B01F13/04 ,  B01F13/045 ,  B01L3/502 ,  B01L3/508 ,  B01L3/50825 ,  B01L9/06 ,  B01L9/52 ,  B01L2200/025 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/0681 ,  B01L2300/0822 ,  B01L2300/0851 ,  B65B7/161 ,  B65B69/00 ,  G01N1/2813 ,  G01N27/22 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/021 ,  G01N35/04 ,  G01N35/1016 ,  G01N2001/1025 ,  G01N2001/2826 ,  G01N2035/00089 ,  G01N2035/00138 ,  G01N2035/0405 ,  G01N2035/0427 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0458 ,  G01N2035/0462 ,  Y10T29/49822 ,  Y10T29/53039 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/12 ,  Y10T436/25375 ,  Y10T436/255

Abstract: An article handling system and method for holding articles and moving selected articles individually from and/or to the article handling system. A plurality of vertically spaced article holding trays are mounted for independent rotation, each tray having a plurality of discrete article holding locations. A tray rotating mechanism is arranged to rotate a single selected tray, while a pick-and-place mechanism has an article gripper mounted for vertical and horizontal movement such that the gripper can reach any article holding location on any selected tray. A controller coordinates rotation of the selected tray and movement of the gripper such that the gripper can move to and from the selected article holding location. The handling system is especially useful as part of an automated system for processing multiple specimens of biological fluid in separate vials.

公开(公告)号：EP1438562A2

公开(公告)日：2004-07-21

申请号：EP02789228.0

申请日：2002-10-21

Applicant: MonoGen, Inc.

Inventor： MAYER, William, J. ,  WROBLEWSKI, Lucien, J.

IPC: G01N1/28 ,  B65G59/06 ,  B65G47/06 ,  G01N35/02

CPC classification number: G01N1/4077 ,  B01D61/18 ,  B01D61/22 ,  B01D63/08 ,  B01D65/08 ,  B01D2321/02 ,  B01D2321/10 ,  B01D2321/16 ,  B01D2321/2008 ,  B01D2321/2016 ,  B01D2321/2066 ,  B01F7/00583 ,  B01F7/1695 ,  B01F13/002 ,  B01F13/04 ,  B01F13/045 ,  B01L3/502 ,  B01L3/508 ,  B01L3/50825 ,  B01L9/06 ,  B01L9/52 ,  B01L2200/025 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/0681 ,  B01L2300/0822 ,  B01L2300/0851 ,  B65B7/161 ,  B65B69/00 ,  G01N1/2813 ,  G01N27/22 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/021 ,  G01N35/04 ,  G01N35/1016 ,  G01N2001/1025 ,  G01N2001/2826 ,  G01N2035/00089 ,  G01N2035/00138 ,  G01N2035/0405 ,  G01N2035/0427 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0458 ,  G01N2035/0462 ,  Y10T29/49822 ,  Y10T29/53039 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/12 ,  Y10T436/25375 ,  Y10T436/255

Abstract: Method and apparatus for storing and dispensing articles, one at a time, from the bottom of a stack of like articles. The articles are yieldably supported in at least one upright stack above an outlet, e.g., a resilient choke, sized to pass the articles if forced therethrough. Articles are dispensed by pressing downwardly on the stack with sufficient force and for sufficient duration to overcome the yieldable supporting force and move the lowest article through the outlet. Sensors may be provided for sensing when an article is dispensed, when the tube is empty, and the type of article in the holder. The method and apparatus are especially useful in a vial-based automated system for processing multiple specimens of biological fluid, wherein a filter assembly must be dispensed into a filtration chamber associated with each specimen vial.

公开(公告)号：EP1436629A1

公开(公告)日：2004-07-14

申请号：EP02789226.4

申请日：2002-10-21

Applicant: MonoGen, Inc.

Inventor： PRESSMAN, Norman, J. ,  MAYER, William, J. ,  WROBLEWSKI, Lucien, J.

IPC: G01N35/00

CPC classification number: G01N1/4077 ,  B01D61/18 ,  B01D61/22 ,  B01D63/08 ,  B01D65/08 ,  B01D2321/02 ,  B01D2321/10 ,  B01D2321/16 ,  B01D2321/2008 ,  B01D2321/2016 ,  B01D2321/2066 ,  B01F7/00583 ,  B01F7/1695 ,  B01F13/002 ,  B01F13/04 ,  B01F13/045 ,  B01L3/502 ,  B01L3/508 ,  B01L3/50825 ,  B01L9/06 ,  B01L9/52 ,  B01L2200/025 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/0681 ,  B01L2300/0822 ,  B01L2300/0851 ,  B65B7/161 ,  B65B69/00 ,  G01N1/2813 ,  G01N27/22 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/021 ,  G01N35/04 ,  G01N35/1016 ,  G01N2001/1025 ,  G01N2001/2826 ,  G01N2035/00089 ,  G01N2035/00138 ,  G01N2035/0405 ,  G01N2035/0427 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0458 ,  G01N2035/0462 ,  Y10T29/49822 ,  Y10T29/53039 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/12 ,  Y10T436/25375 ,  Y10T436/255

Abstract: A microscope slide cassette for use with specimen handling apparatus. A plurality of opposed pairs of shelves carried by the side walls of the cassette are adapted to support specimen slides by their ends in the cassette. The shelves have a top surface on which a specimen slide can rest, and a resilient bottom surface configured to pinch the slide below against the shelf below to frictionally retain the pinched slide in the cassette. The bottom surface may comprise a spring. An inclined shelf lead-in ramp guides slides during insertion. Drainage ports in the side walls above and/or below the shelves make the cassette well suited for use in staining baths. Two laterally spaced racks on the rear wall, vertically spaced indexing marks corresponding to each slide position, and a sensor window at each slide position make the cassette well-suited for use in automated slide cassette handling mechanisms. The cassette is stackable with others for compact storage.

Abstract translation: 用于样本处理设备的显微镜载玻片盒。 由盒的侧壁携带的多对相对的搁架适于通过其在盒中的端部来支撑样本载玻片。 搁架具有试样滑块可以搁置在其上的顶表面以及构造成将滑块夹紧在下面的搁架上以将摩擦地保持在卡匣中的滑动件的弹性底表面。 底表面可以包括弹簧。 插入过程中，倾斜的货架导入坡道导向滑道。 搁架上方和/或下方的侧壁上的排水口使得该盒适合用于染浴。 后壁上的两个横向间隔的支架，对应于每个滑动位置的垂直间隔的分度标记以及每个滑动位置处的传感器窗口使得盒子非常适合用于自动化幻灯片盒处理机构。 盒式磁带可与其他设备堆叠以实现紧凑存储。

公开(公告)号：EP1436199A1

公开(公告)日：2004-07-14

申请号：EP02784158.4

申请日：2002-10-21

Applicant: MonoGen, Inc.

Inventor： MAYER, William, J. ,  WROBLEWSKI, Lucien, J.

IPC: B65B7/16 ,  G01N35/00

CPC classification number: G01N1/4077 ,  B01D61/18 ,  B01D61/22 ,  B01D63/08 ,  B01D65/08 ,  B01D2321/02 ,  B01D2321/10 ,  B01D2321/16 ,  B01D2321/2008 ,  B01D2321/2016 ,  B01D2321/2066 ,  B01F7/00583 ,  B01F7/1695 ,  B01F13/002 ,  B01F13/04 ,  B01F13/045 ,  B01L3/502 ,  B01L3/508 ,  B01L3/50825 ,  B01L9/06 ,  B01L9/52 ,  B01L2200/025 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/0681 ,  B01L2300/0822 ,  B01L2300/0851 ,  B65B7/161 ,  B65B69/00 ,  G01N1/2813 ,  G01N27/22 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/021 ,  G01N35/04 ,  G01N35/1016 ,  G01N2001/1025 ,  G01N2001/2826 ,  G01N2035/00089 ,  G01N2035/00138 ,  G01N2035/0405 ,  G01N2035/0427 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0458 ,  G01N2035/0462 ,  Y10T29/49822 ,  Y10T29/53039 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/12 ,  Y10T436/25375 ,  Y10T436/255

Abstract: Method and apparatus for applying seals made of thin material to the open tops of containers, e.g., specimen containers for holding biological fluid that are processed automatically. A measured length of sealing material is advanced across and pressed against the top of the container (20) to effect a seal. Depending on the type of sealing material used, sealing may be accomplished by application of pressure alone, by application of heat and pressure, or by application of ultrasonic energy and pressure. Excess sealing material optionally may be folded against the container sides by means of a folding member adapted to surround a container (20) when the sealing head is lowered. Motor-driven rollers advance the sealing material, while a platen (854) on a movably mounted sealing head presses the sealing material into engagement with the container.

公开(公告)号：EP1438562B1

公开(公告)日：2007-06-27

申请号：EP02789228.0

申请日：2002-10-21

Applicant: MonoGen, Inc.

Inventor： MAYER, William, J. ,  WROBLEWSKI, Lucien, J.

IPC: G01N1/28 ,  B65G59/06 ,  B65G47/06 ,  G01N35/02

CPC classification number: G01N1/4077 ,  B01D61/18 ,  B01D61/22 ,  B01D63/08 ,  B01D65/08 ,  B01D2321/02 ,  B01D2321/10 ,  B01D2321/16 ,  B01D2321/2008 ,  B01D2321/2016 ,  B01D2321/2066 ,  B01F7/00583 ,  B01F7/1695 ,  B01F13/002 ,  B01F13/04 ,  B01F13/045 ,  B01L3/502 ,  B01L3/508 ,  B01L3/50825 ,  B01L9/06 ,  B01L9/52 ,  B01L2200/025 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/0681 ,  B01L2300/0822 ,  B01L2300/0851 ,  B65B7/161 ,  B65B69/00 ,  G01N1/2813 ,  G01N27/22 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/021 ,  G01N35/04 ,  G01N35/1016 ,  G01N2001/1025 ,  G01N2001/2826 ,  G01N2035/00089 ,  G01N2035/00138 ,  G01N2035/0405 ,  G01N2035/0427 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0458 ,  G01N2035/0462 ,  Y10T29/49822 ,  Y10T29/53039 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/12 ,  Y10T436/25375 ,  Y10T436/255

Abstract: Method and apparatus for storing and dispensing articles, one at a time, from the bottom of a stack of like articles. The articles are yieldably supported in at least one upright stack above an outlet, e.g., a resilient choke, sized to pass the articles if forced therethrough. Articles are dispensed by pressing downwardly on the stack with sufficient force and for sufficient duration to overcome the yieldable supporting force and move the lowest article through the outlet. Sensors may be provided for sensing when an article is dispensed, when the tube is empty, and the type of article in the holder. The method and apparatus are especially useful in a vial-based automated system for processing multiple specimens of biological fluid, wherein a filter assembly must be dispensed into a filtration chamber associated with each specimen vial.

公开(公告)号：EP1438559B1

公开(公告)日：2007-06-20

申请号：EP02773810.3

申请日：2002-10-21

Applicant: MonoGen, Inc.

Inventor： PRESSMAN, Norman, J. ,  MAYER, William, J. ,  WROBLEWSKI, Lucien, J.

IPC: G01N1/28

CPC classification number: G01N1/4077 ,  B01D61/18 ,  B01D61/22 ,  B01D63/08 ,  B01D65/08 ,  B01D2321/02 ,  B01D2321/10 ,  B01D2321/16 ,  B01D2321/2008 ,  B01D2321/2016 ,  B01D2321/2066 ,  B01F7/00583 ,  B01F7/1695 ,  B01F13/002 ,  B01F13/04 ,  B01F13/045 ,  B01L3/502 ,  B01L3/508 ,  B01L3/50825 ,  B01L9/06 ,  B01L9/52 ,  B01L2200/025 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/0681 ,  B01L2300/0822 ,  B01L2300/0851 ,  B65B7/161 ,  B65B69/00 ,  G01N1/2813 ,  G01N27/22 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/021 ,  G01N35/04 ,  G01N35/1016 ,  G01N2001/1025 ,  G01N2001/2826 ,  G01N2035/00089 ,  G01N2035/00138 ,  G01N2035/0405 ,  G01N2035/0427 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0458 ,  G01N2035/0462 ,  Y10T29/49822 ,  Y10T29/53039 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/12 ,  Y10T436/25375 ,  Y10T436/255

Abstract: A method and apparatus for collecting a cell sample of desired concentration on a filter collection site from a biological liquid specimen in a container. Specimen liquid is moved through a filter while the volume rate of liquid flow through the filter is monitored. The monitored liquid flow rate is compared to a reference value, and liquid flow through the filter is terminated when the ratio value. The predetermined ratio value preferably is a function of the protocol for processing the specimen. An alternative method and apparatus relies on the rate of change of the measured weight of the container. This rate is compared to a reference value, and liquid flow through the filter is terminated when the rate of change diminishes to or below a predetermined value.

公开(公告)号：EP1438559A2

公开(公告)日：2004-07-21

申请号：EP02773810.3

申请日：2002-10-21

Applicant: MonoGen, Inc.

Inventor： PRESSMAN, Norman, J. ,  MAYER, William, J. ,  WROBLEWSKI, Lucien, J.

IPC: G01N1/28

CPC classification number: G01N1/4077 ,  B01D61/18 ,  B01D61/22 ,  B01D63/08 ,  B01D65/08 ,  B01D2321/02 ,  B01D2321/10 ,  B01D2321/16 ,  B01D2321/2008 ,  B01D2321/2016 ,  B01D2321/2066 ,  B01F7/00583 ,  B01F7/1695 ,  B01F13/002 ,  B01F13/04 ,  B01F13/045 ,  B01L3/502 ,  B01L3/508 ,  B01L3/50825 ,  B01L9/06 ,  B01L9/52 ,  B01L2200/025 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/0681 ,  B01L2300/0822 ,  B01L2300/0851 ,  B65B7/161 ,  B65B69/00 ,  G01N1/2813 ,  G01N27/22 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/021 ,  G01N35/04 ,  G01N35/1016 ,  G01N2001/1025 ,  G01N2001/2826 ,  G01N2035/00089 ,  G01N2035/00138 ,  G01N2035/0405 ,  G01N2035/0427 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0458 ,  G01N2035/0462 ,  Y10T29/49822 ,  Y10T29/53039 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/12 ,  Y10T436/25375 ,  Y10T436/255

Abstract: A method and apparatus for collecting a cell sample of desired concentration on a filter collection site from a biological liquid specimen in a container. Specimen liquid is moved through a filter while the volume rate of liquid flow through the filter is monitored. The monitored liquid flow rate is compared to a reference value, and liquid flow through the filter is terminated when the ratio value. The predetermined ratio value preferably is a function of the protocol for processing the specimen. An alternative method and apparatus relies on the rate of change of the measured weight of the container. This rate is compared to a reference value, and liquid flow through the filter is terminated when the rate of change diminishes to or below a predetermined value.