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42 条记录 (耗时 0.017 秒)

    Novel peptides, and antidementia agents containing the same
    6.
    发明公开
    Novel peptides, and antidementia agents containing the same 失效
    肽和多肽肽enthaltende Wirkstoffe gegen痴呆。

    公开(公告)号：EP0393934A1

    公开(公告)日：1990-10-24

    申请号：EP90303987.3

    申请日：1990-04-12

    申请人： NIPPON CHEMIPHAR CO., LTD. ,  FUJIREBIO KABUSHIKI KAISHA

    发明人： Masaki, Mitsuo ,  Uehara, Masaki ,  Hirate, Kenji ,  Isowa, Yoshikazu ,  Sato, Yoshiaki ,  Nakashima, Yoshiharu

    IPC分类号： C07K5/10 ,  C07K7/16 ,  A61K37/02

    CPC分类号： C07K5/0202 ,  A61K38/00 ,  C07K5/1013 ,  C07K5/1024 ,  C07K7/16

    摘要： Disclosed is a novel peptide having one of the formulae:


    (A and B are the amino acids: wherein
    if A is D- or L-Pro, B is Har or Cit;
    if A is D-Pro, B is D-Arg, and
    if B is D- or L-Arg, A is Sar, Pip, Aze or Arg)
    Asn-A-L-(D-)Pro-Arg-(Gly) n (A is Ser, Thr or Ala, n is 1 or 0)
    A-Ser-Pip-Arg (A is Pro-Asn-, Asn- or Pro-) W
    A- C ys-Pro-Arg-B (A is cyclopentylcarbonyl, Pro or pGlu; B is Gly or β-Ala, W is a hydrogen atom or a group having the formula:
    or a peptide having the formula:
    wherein A and B have the same meanings as mentioned above, respectively
    pGlu-Asn-Ser-A-B-(Gl y )n (A is Aze, D- or L-Pro, Pip or Sar, B is D- or L-Arg, Cit, Har, Lys or Orn, n is 1 or 0) and
    Pro-(Asn) m Ser-L-(D-)Pro-Arg-(Gly) n (m and n are independently 0 or 1)
    their functional derivatives, and pharmaceutically acceptable salts thereof.

    摘要翻译： 公开了具有以下结构之一的新型肽：（A和B是氨基酸：其中如果A是D-或L-Pro，B是Har或Cit;如果A是D-Pro，B是D -Arg，如果B是D-或L-Arg，A是Sar，Pip，Aze或Arg）Asn-AL-（D-）Pro-Arg-（Gly）n（A是Ser，Thr或Ala，n A-Ser-Pip-Arg（A为Pro-Asn-，Asn-或Pro-）A-ys-Pro-Arg-B（A为环戊基羰基，Pro或pGlu; B为Gly或β -Ala，W是氢原子或具有下式的基团：H-ys-OH）或具有下式的肽：（A- @ ys-Pro-Arg-B）2其中A和B具有相同的含义 如上所述，分别为pGlu-Asn-Ser-AB-（Gly）n（A为Aze，D-或L-Pro，Pip或Sar，B为D-或L-Arg，Cit，Har，Lys或Orn， n为1或0）和Pro-（Asn）m-Ser-L-（D-）Pro-Arg-（Gly）n（m和n独立地为0或1）其功能衍生物及其药学上可接受的盐。

    Imidazole derivatives, process for the preparation of the same and antiulcer agents containing the same
    8.
    发明公开
    Imidazole derivatives, process for the preparation of the same and antiulcer agents containing the same 失效
    咪唑ivate ivate ivate。。。。。。。。。。。。。。。。。。。。。

    公开(公告)号：EP0412529A1

    公开(公告)日：1991-02-13

    申请号：EP90115236.3

    申请日：1990-08-08

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Okabe, Susumu, 287-5, Shingoryouguchi-cho ,  Masaki, Mitsuo ,  Yamakawa, Tomio ,  Matsukura, Hitoshi ,  Nomura, Yustaka

    IPC分类号： C07D233/84 ,  A61K31/415

    CPC分类号： C07D233/84

    摘要： Disclosed are novel imidazole derivatives having the formula:
    wherein R¹ is hydrogen or an alkyl group having 1-6 carbon atoms, R² is an alkyl group having 2-6 carbon atoms substi­tuted with an alkoxy group having 1-4 carbon atoms, each of R³, R⁴, R⁵ and R⁶ independently is hydrogen, a halogen, an alkyl group having 1-6 carbon atoms, an alkoxy group having 1-6 carbon atoms, a fluorine-substituted alkyl group having 1-6 carbon atoms, or a fluorine-substituted alkoxy group having 1-6 carbon atoms. The new imidazole derivatives are effective particularly as anti-ulcer agents.

    摘要翻译： 公开了具有下式的新型咪唑衍生物：其中R 1是氢或具有1-6个碳原子的烷基，其中R 2是具有2-6个碳原子的烷基， 1-4个碳原子，R 3，R 4，R 5和R 6各自独立地是氢，卤素，具有1-6个碳原子的烷基，具有1- 6个碳原子，具有1-6个碳原子的氟取代的烷基或具有1-6个碳原子的氟取代的烷氧基。 新的咪唑衍生物特别有效地用作抗溃疡剂。

    Novel imidazole derivatives
    9.
    发明公开
    Novel imidazole derivatives 失效
    Imidazolderivate，

    公开(公告)号：EP0354788A1

    公开(公告)日：1990-02-14

    申请号：EP89308119.0

    申请日：1989-08-10

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Okabe, Susumu 287-5, Shingoryouguchi-cho ,  Masaki, Mitsuo ,  Yamakawa, Tomio ,  Matsukura, Hitoshi ,  Nomura, Yutaka

    IPC分类号： C07D233/84 ,  C07D235/28

    CPC分类号： C07D235/28 ,  C07D233/84

    摘要： Disclosed are novel imidazole derivatives having the formula:
    wherein R 1 and R 2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R 1 and R 2 are combined to form a heterocyclic ring; R 3 , R 4 , R 5 and R 6 are H, halogen, alkoxy, aralkyloxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, or fluorine substituted-alkoxy, or R 3 is combined with R 2 to form a heterocyclic ring; R 8 and R 9 are H, halogen, alkoxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, fluorine substituted-alkoxy, or aryl group which may have a substitutent, or R 8 and R 9 are combined to form an alicyclic ring; R 7 is, where R 8 and R 9 are not combined, H, and, where R 8 and R 9 are combined, H, alkyl which may have a substitutent, aryl which may have a substitutent, arylcarbonyl which may have a substitutent, or a sulfur-containing heterocyclic group; and n is 0 or 1. The new imidazole derivatives are effective particularly as anti-ulcer agents.

    摘要翻译： 公开了具有下式的新型咪唑衍生物：其中R 1和R 2是H，烷基，环烷基，芳基，芳烷基或卤素取代的烷基，或R 1和R 2相结合的 形成杂环; R 3，R 4，R 5和R 6是H，卤素，烷氧基，芳烷氧基，烷基，烷氧基羰基，硝基，氨基，酰基，氟取代的烷基或氟取代的烷氧基 R 3与R 2结合形成杂环; R 8和R 9是可以具有取代基的H，卤素，烷氧基，烷基，烷氧基羰基，硝基，氨基，酰基，氟取代的烷基，氟取代的烷氧基或芳基，或R 8， 和R 9结合形成脂环族环; R 7是其中R 8和R 9不组合的化合物，其中R 8和R 9结合，H可以具有取代基的烷基，其可以具有 可以具有取代基的取代基芳基羰基或含硫杂环基; 并且n为0或1.新的咪唑衍生物特别用作抗溃疡剂。

    Amino-alcohol derivatives and processes for their preparation
    10.
    发明公开
    Amino-alcohol derivatives and processes for their preparation 失效
    Aminoalkohol-Derivate und Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0177245A2

    公开(公告)日：1986-04-09

    申请号：EP85306767.6

    申请日：1985-09-24

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Masaki, Mitsuo ,  Shinozaki, Haruhiko ,  Satoh, Masuru ,  Moritoh, Naoya ,  Hashimoto, Koichi ,  Kamishiro, Toshiro

    IPC分类号： C07D295/12 ,  C07C215/56 ,  C07C217/44

    CPC分类号： C07D295/13

    摘要： Amino-alcohol derivatives of the formula,
    where R, is a straight or branched alkyl group having 3 to 8 carbon atoms, R 2 and R 3 are each a lower alkyl group, or R 2 and R 3 form a 5- to 7-membered ring together with the adjacent nitrogen atom which may have an oxygen atom attached thereto, R. is a hydrogen atom or a lower alkyl group, R 5 is a hydrogen atom or a lower alkyl group, X is a hydrogen or halogen atom or a lower alkyl or lower alkoxy group, and n is an integer of 2 or 3, and acid addition salts thereof, are effectively useful as medicines and agricultural chemicals. Processes are also disclosed for preparing such compounds.

    摘要翻译： 其中R 1是具有3至8个碳原子的直链或支链烷基，R 2和R 3各自是低级烷基，或者R 2和R 3形成5-至7-元环的下式的氨基醇衍生物 与可能具有氧原子的相邻氮原子一起，R4是氢原子或低级烷基，R5是氢原子或低级烷基，X是氢或卤素原子或低级烷基或低级烷基 烷氧基，n为2或3的整数，其酸加成盐可有效用作药物和农药。 还公开了制备这些化合物的方法。