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    TRICYCLIC CONDENSED HETEROCYCLIC COMPOUND, METHOD FOR PRODUCING SAME, AND USE THEREOF
    1.
    发明公开
    TRICYCLIC CONDENSED HETEROCYCLIC COMPOUND, METHOD FOR PRODUCING SAME, AND USE THEREOF 有权
    TRICYCLISCHE KONDENSIERTE HETEROCYCLISCHE VERBINDUNG，HERSTELLUNGSVERFAHRENDAFÜRUND VERWENDUNG DAVON

    公开(公告)号：EP2415768A1

    公开(公告)日：2012-02-08

    申请号：EP10758499.7

    申请日：2010-03-24

    申请人： Nippon Suisan Kaisha, Ltd.

    发明人： SATO, Seizo ,  IWATA, Fumie ,  YAMADA, Shoichi ,  TAKEO,Jiro ,  ABE, Akihisa ,  KAWAHARA, Hiroyuki

    IPC分类号： C07D307/77 ,  A61K31/343 ,  A61K35/74 ,  A61P35/00 ,  C12P15/00 ,  C12P17/04

    CPC分类号： C07D307/93 ,  C07D307/77 ,  C12P17/04 ,  C12R1/465

    摘要： A novel compound derived from the culture product of an actinomycete and having an antitumor activity is provided. Provided is a compound represented by any one of formulas (I), (II) and (III)



    or an optical isomer thereof or a pharmaceutically acceptable salt thereof which can be isolated from the culture fluid of an actinomycete which belongs to the genus Streptomyces,
    wherein R 1 R 2 , R 5 and R 6 each independently represent a hydrogen atom, a methyl group, a hydroxymethyl group, a hydroxyl group, or a double bond by which R 1 and R 2 or R 5 and R 6 are bonded; R 3 , R 4 , R 7 and R 8 each independently represent a methyl group or a hydroxymethyl group; and R 9 represents a hydrogen atom or a hydroxyl group.

    摘要翻译： 提供衍生自放线菌培养物并具有抗肿瘤活性的新化合物。 提供可以从属于链霉菌属的放线菌的培养液中分离的由式（I），（II）和（III）中的任何一种表示的化合物或其旋光异构体或其药学上可接受的盐， 其中R 1 R 2，R 5和R 6各自独立地表示氢原子，甲基，羟甲基，羟基或R 1和R 2或R 5和R 6键合的双键。 R 3，R 4，R 7和R 8各自独立地表示甲基或羟甲基; R 9表示氢原子或羟基。

    FISH MEAL WITH INHIBITED OXIDATION AND PROCESS FOR PRODUCING THE SAME
    6.
    发明公开
    FISH MEAL WITH INHIBITED OXIDATION AND PROCESS FOR PRODUCING THE SAME 审中-公开
    FISCHMEHL MIT GEHEMMTER OXIDATION UND VERFAHREN ZU SEINER HERSTELLUNG

    公开(公告)号：EP2018812A1

    公开(公告)日：2009-01-28

    申请号：EP07742893.6

    申请日：2007-05-07

    申请人： NIPPON SUISAN KAISHA, LTD.

    发明人： DOISAKI, Nobushige ,  KAWAHARA, Hiroyuki ,  HATA, Kazuhiko

    IPC分类号： A23K1/10 ,  A23K1/00 ,  A23K1/16 ,  C09K15/06 ,  C09K15/34

    CPC分类号： A23K20/10 ,  A23K10/22 ,  A23K20/158 ,  A23K20/174 ,  A23L17/10

    摘要： [Problem]
    The problem for the present invention is to provide an antioxidation formulation that is highly safe due to derivation from natural substances and that has an effect when used in fish meal that is at least equivalent to that of the presently utilized ethoxyquin.
    [Means to Solve the Problem]
    A fish meal contains a vegetable oil distillation-deodorizing distillate as an added antioxidant substance, or the fish meal contains an added vegetable oil distillation-deodorizing distillate and ascorbic acid, or a salt thereof, or an ester thereof A method of production of fish meal controls oxidation by addition of a vegetable oil distillation-deodorizing distillate or by addition the vegetable oil distillation-deodorizing distillate and ascorbic acid, or a salt thereof, or an ester thereof An antioxidation composition for fish meal contains a vegetable oil distillation-deodorizing distillate or the antioxidation composition contains the added vegetable oil distillation-deodorizing distillate and ascorbic acid, or a salt thereof, or an ester thereof A feed is produced by use as raw material of a fish meal to which has been added a vegetable oil distillation-deodorizing distillate or the vegetable oil distillation-deodorizing distillate and ascorbic acid, or a salt thereof, or an ester thereof.

    摘要翻译： 本发明的问题在于提供一种抗氧化剂，其由于天然物质的衍生而具有高度的安全性，并且当用于至少等同于目前使用的乙氧喹的鱼粉时具有效果。 [解决问题的方法]鱼粉含有植物油蒸馏除臭馏出物作为添加的抗氧化剂物质，或者鱼粉含有添加的植物油蒸馏除臭馏出物和抗坏血酸或其盐或其酯 鱼粉的生产方法通过添加植物油蒸馏除臭馏出物或通过加入植物油蒸馏除臭馏分和抗坏血酸或其盐或其酯来控制氧化。鱼粉的抗氧化组合物含有 植物油蒸馏除臭馏出物或抗氧化组合物含有添加的植物油蒸馏除臭馏出物和抗坏血酸或其盐或其酯通过使用已经加入的鱼粉的原料来生产饲料 植物油蒸馏除臭馏出物或植物油蒸馏除臭馏出物和抗坏血酸 ，或其盐，或其酯。

    METHOD FOR PRODUCTION OF EPA-ENRICHED OIL AND DHA-ENRICHED OIL
    10.
    发明公开
    METHOD FOR PRODUCTION OF EPA-ENRICHED OIL AND DHA-ENRICHED OIL 有权
    VERFAHREN ZUR HERSTELLUNG VON MIT EPA ANGEREICHERTEMÖLUND MIT DHA ANGEREICHERTEMÖL

    公开(公告)号：EP2172558A1

    公开(公告)日：2010-04-07

    申请号：EP08791785.2

    申请日：2008-07-29

    申请人： NIPPON SUISAN KAISHA, LTD.

    发明人： FURIHATA, Kiyomi ,  KAWAHARA, Hiroyuki ,  YAMAGUCHI, Hideaki ,  IKEMOTO, Hideo ,  DOISAKI, Nobushige

    IPC分类号： C12P7/64 ,  C11C3/10

    CPC分类号： C11C1/045 ,  C11C3/10 ,  C12P7/6472

    摘要： Alcoholysis of oils and fats containing EPA and DHA is performed by a lipase having substrate specificity for fatty acids having 18 carbons or less and in the presence of a reaction additive such as magnesium oxide; then the glyceride fraction is separated; alcoholysis of the glyceride fraction is performed by a lipase having substrate specificity for fatty acids having 20 carbons or less and in the presence of a reaction additive such as magnesium oxide; and EPA-enriched oil and DHA-enriched oil are simultaneously obtained.

    摘要翻译： 含有EPA和DHA的油和脂肪的醇解通过对具有18个或更少碳原子的脂肪酸和在诸如氧化镁的反应添加剂存在下具有底物特异性的脂肪酶进行， 然后分离甘油酯级分; 甘油酯级分的醇解通过对具有20个碳以下的脂肪酸和在氧化镁等反应添加剂的存在下具有底物特异性的脂肪酶进行， 同时获得富含EPA的油和富含DHA的油。