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1.发明公开alpha-AMINO ACID DERIVATIVE AND PHARMACEUTICAL COMPRISING THE SAME AS ACTIVE INGREDIENT 审中-公开α-氨基酸衍生物和药物，这作为活性成分的
公开(公告)号：EP2045253A4
公开(公告)日：2013-01-23
申请号：EP07767879
申请日：2007-06-29
发明人： OHRAI KAZUHIKO , ADACHI MICHIAKI , TOYAMA KOJI , SHIMIZU TAKANORI , HAYASHI KEISHI , MINAMI MASATAKA , SUZUKI YOSHIYUKI , SUGIYAMA MASAKAZU , OHTA MASATERU , KADONO SHOJIRO , SHIRAISHI TAKUYA , SATO HARUHIKO , WATANABE YOSHIAKI , ISHII NOBUYA , SAKAITANI MASAHIRO , HASEGAWA MASAMI
IPC分类号： C07D513/04 , A61K31/429 , A61K31/4439 , A61P9/04 , A61P35/00 , A61P43/00
CPC分类号： C07D513/04
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公开(公告)号：EP1304334A4
公开(公告)日：2009-06-17
申请号：EP01945764
申请日：2001-07-02
IPC分类号： A61K31/565 , A61P13/08 , A61P15/00 , A61P17/00 , A61P17/08 , A61P17/14 , A61P35/00 , C07J1/00 , C07J41/00
CPC分类号： C07J41/0038 , A61K31/565 , C07J1/00 , C07J1/0022 , C07J41/00 , Y02P20/55
摘要： A compound represented by the general formula (I) useful as an antiandrogenic agent, a pharmacologically acceptable salt thereof, or a prodrug comprising either of these: (I) wherein X?1 and X2¿ each independently represents hydrogen or a substituent such as, e.g., Ra represents hydrogen or a hydroxyl-protecting group; R?b and Rc¿ in combination represent optionally protected -(C=O)- in cooperation with the 3-position carbon atom bonded to these; and the broken line indicates a single bond or double bond in cooperation with the solid line.
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公开(公告)号：EP1790640A4
公开(公告)日：2009-07-29
申请号：EP05782020
申请日：2005-09-09
发明人： TACHIBANA KAZUTAKA , SATO HARUHIKO , OHTA MASATERU , NAKAMURA MITSUAKI , SHIRAISHI TAKUYA , YOSHINO HITOSHI , EMURA TAKASHI , HONMA AKIE , ONUMA ETSURO , KAWATA HIROMITSU , TANIGUCHI KENJI
IPC分类号： C07D233/86 , A61K31/4166 , A61K31/428 , A61K31/454 , A61K31/496 , A61P5/24 , A61P5/28 , A61P13/08 , A61P17/00 , A61P17/08 , A61P17/10 , C07D211/58 , C07D233/74
CPC分类号： C07D417/04 , C07D211/58 , C07D233/74 , C07D233/86 , C07D277/82 , C07D401/04
摘要： A compound represented by the formula (I): [Chemical formula 1] (I) [wherein Q is a group represented by the formula; [Chemical formula 2] (X) or (Y) A is hydrogen, halogeno, -ORa, or C1-4 alkyl optionally substituted by one or more halogen atoms; E's each independently is C1-6 alkyl; m is an integer of 0-3; R2 and R3 each independently is C1-6 alkyl; X1 and X2 each independently is O or S; Y is one member selected among arylene, a divalent 5- or 6-membered monocyclic heterocyclic group, and a divalent 8- to 10-membered fused-ring heterocyclic group;and Z is -CON(-Ra)-, -CO-, -COO-, -NRa-C(=NH)NRb-, -NRa-(C=N-CN)NRb-, -N(-Ra)COO-, -C(=NH)-, -SO2-, -SO2N(-Ra)-, -SO2NR1-, -N(-Ra)CO-, -N(-Ra)CON(-Rb)-, -N(COR1)CO-, -N(-Ra)SO2-, -N(SO2R1)SO2-, -N(-Ra)-, or -N(-Ra)SO2N(-Rb)-], or a salt, prodrug, or solvate of the compound. Also provided is a medicinal composition containing the compound or the like.
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公开(公告)号：EP1634874A4
公开(公告)日：2008-04-02
申请号：EP04745805
申请日：2004-06-11
发明人： TACHIBANA KAZUTAKA , SATO HARUHIKO , OHTA MASATERU , NAKAMURA MITSUAKI , SHIRAISHI TAKUYA , IMAOKA IKUHIRO , YOSHINO HITOSHI , NAGAMUTA MASAHIRO , KAWATA HIROMITSU
IPC分类号： C07D233/86 , A61K31/4166 , A61P5/28 , A61P13/08 , A61P17/02 , A61P17/10 , A61P17/14 , A61P35/00 , A61P43/00
CPC分类号： C07D233/86
摘要： A compound represented by the formula (I): (wherein n is an integer selected among 1 to 20; and R1 and R2 may be the same or different and each represents hydrogen or linear or branched, C1-6 alkyl) and a salt, prodrug, and solvate of the compound. Also provided are a medicine and a medicinal composition which each contains the compound.
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公开(公告)号：EP2433940A4
公开(公告)日：2012-10-10
申请号：EP10769728
申请日：2010-04-27
发明人： ESAKI TORU , NISHIMURA YOSHIKAZU , ISSHIKI YOSHIAKI , OKAMOTO NAOKI , FURUTA YOSHIYUKI , MIZUTANI AKEMI , OHTA MASATERU , LAI WAYNE WEN , KOTAKE TOMOYA
IPC分类号： C07D471/10 , A61K31/438 , A61K31/444 , A61K31/496 , A61K31/5355 , A61P5/20 , A61P7/08 , A61P19/02 , A61P19/08 , A61P43/00 , C07D487/10
CPC分类号： C07D471/10 , C07D471/20 , C07D491/107 , C07D513/20 , C07D513/22 , C07D515/20
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公开(公告)号：EP1775289A4
公开(公告)日：2009-09-02
申请号：EP05768418
申请日：2005-08-03
发明人： TACHIBANA KAZUTAKA , SATO HARUHIKO , OHTA MASATERU , NAKAMURA MITSUAKI , SHIRAISHI TAKUYA , IMAOKA IKUHIRO , YOSHINO HITOSHI , NAGAMUTA MASAHIRO , KAWATA HIROMITSU
IPC分类号： C07D233/66 , A61K31/4164 , A61P13/08 , A61P15/00 , A61P17/00 , A61P17/08 , A61P17/14 , A61P35/00 , A61P43/00
CPC分类号： C07D233/86 , C07D233/76
摘要： Compounds represented by the general formula (I); and drugs and medicinal compositions, containing the compounds: (I) wherein n is an integer of 1 to 20; Q is (II) or (III) A is cyano or the like; B is hydrogen, halogeno, or the like; X1 and X2 are each independently selected from between O and S; E is C1-4 alkyl; and R1, R2, R3 and R4 are each independently selected from between hydrogen and C1-6 alkyl.
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