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公开(公告)号：EP2583691A4
公开(公告)日：2016-04-27
申请号：EP11795835
申请日：2011-06-17
申请人： NITTO DENKO CORP
IPC分类号： A61K47/10 , A61K9/127 , A61K31/7088 , A61K31/713 , A61K45/00 , A61K48/00 , A61P13/12 , A61P43/00
CPC分类号： C12N15/113 , A61K9/127 , A61K31/07 , A61K31/7088 , A61K31/713 , A61K47/10 , A61K47/542 , A61K47/6911 , A61K47/6919 , A61K47/6921 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： The present invention relates to a substance delivery carrier for extracellular matrix-producing cells in the kidney, the carrier including a retinoid as a targeting agent, an agent for treating renal fibrosis utilizing the carrier, a process for producing them, a production kit, a method for treating renal fibrosis using the agent for treating renal fibrosis, etc.
摘要翻译： 本发明涉及肾脏中细胞外基质产生细胞的物质递送载体，载体包括类视黄醇作为靶向剂，利用载体治疗肾纤维化的药剂，其制备方法，制备试剂盒， 使用治疗肾纤维化的药物治疗肾纤维化的方法等
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2.发明公开
公开(公告)号：EP1842557A4
公开(公告)日：2011-08-10
申请号：EP05819552
申请日：2005-12-22
申请人： NITTO DENKO CORP
发明人： NIITSU YOSHIRO , KATO JUNJI , SATO YASUSHI
IPC分类号： A61K47/10 , A61K9/107 , A61K9/127 , A61K9/50 , A61K9/51 , A61K31/7088 , A61K45/00 , A61K47/14 , A61K48/00 , A61P43/00
CPC分类号： A61K31/07 , A61K9/0019 , A61K9/127 , A61K9/14 , A61K31/7088 , A61K38/1833 , A61K38/1841 , A61K38/1858 , A61K45/06 , A61K47/6911 , Y10S514/893 , Y10T428/2982 , A61K2300/00
摘要： An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.
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公开(公告)号：EP2937099A4
公开(公告)日：2016-07-27
申请号：EP13865094
申请日：2013-12-20
申请人： NITTO DENKO CORP
发明人： NIITSU YOSHIRO , NISHITA HIROKI , TANAKA HIROYUKI
IPC分类号： A61K45/06 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K48/00 , A61P35/00 , A61P43/00 , C12N15/113
CPC分类号： C12Y205/01018 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , C12N15/1137 , C12N2310/14
摘要： The purpose of the present invention is to provide a composition for effectively inducing apoptosis and/or proliferation inhibition in a cell, and a method using the same. An agent for inducing apoptosis that comprises as active ingredients a drug inhibiting GST-À and a drug inhibiting Akt; a medicinal composition comprising the same; a method for treating a disease caused by abnormality in apoptosis using the same, etc.
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4.发明公开TARGETING AGENT FOR CANCER CELL OR CANCER-ASSOCIATED FIBROBLAST 审中-公开对肿瘤细胞或肿瘤相关成纤维细胞的作用是防止SANTANDER ACTIVE
公开(公告)号：EP2135600A4
公开(公告)日：2013-10-16
申请号：EP08739842
申请日：2008-03-28
申请人： NITTO DENKO CORP
发明人： NIITSU YOSHIRO , TAKIMOTO RISHU
IPC分类号： A61K9/127 , A61K9/107 , A61K9/50 , A61K9/51 , A61K31/704 , A61K31/713 , A61K45/00 , A61K47/08 , A61K48/00 , A61P35/00 , A61P43/00
CPC分类号： A61K47/10 , A61K9/0019 , A61K9/127 , A61K31/07 , A61K31/704 , A61K31/713 , A61K47/6911 , A61K48/00 , A61K48/005 , A61K2300/00 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2799/04 , C12N2810/10
摘要： Disclosed are a novel therapeutic agent and a novel treatment method for cancer. Specifically disclosed are: a targeting agent for a cell selected from the group consisting of a cancer cell and a cancer-associated fibroblast, which comprises a retinoid; a substance delivery carrier for the cell, which comprises the targeting agent; an anti-cancer composition utilizing the targeting agent or the carrier; an anti cancer-associated fibroblast composition; and a method for treatment of cancer.
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公开(公告)号：EP3159402A4
公开(公告)日：2018-01-17
申请号：EP15810202
申请日：2015-06-18
申请人： NITTO DENKO CORP
发明人： NIITSU YOSHIRO , YONEDA AKIHIRO
CPC分类号： A61K38/06 , A61K35/12 , A61K38/00 , A61K38/18 , A61K38/22 , A61L27/00 , C12N5/0671 , C12N2501/10 , C12N2501/998
摘要： The purpose of the present invention is to provide a novel tissue regeneration promoter and method for promoting tissue regeneration. The present invention pertains to: a composition for promoting tissue regeneration and/or promoting cell growth, the composition containing an RGD peptide; a method for promoting tissue regeneration and/or promoting cell growth using RGD peptide; and the like.
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公开(公告)号：EP2937090A4
公开(公告)日：2016-08-03
申请号：EP13866361
申请日：2013-12-20
申请人： NITTO DENKO CORP
发明人： NIITSU YOSHIRO , YONEDA AKIHIRO
CPC分类号： A61K38/4886 , A61K35/12 , A61K35/407 , A61K38/014 , A61K38/39 , C12M23/20 , C12M25/14 , C12Y304/2408
摘要： The purpose of the present invention is to provide a novel tissue regeneration accelerator and tissue regeneration method. The present invention relates to: a composition for accelerating tissue regeneration, accelerating cell differentiation and/or accelerating cell multiplication comprising a component selected from the group consisting of activated stellate cells, the decomposition product of activated stellate cells, MMP14, collagen that has been treated with MMP14, and the secretion product of activated stellate cells; a composition for suppressing cell multiplication comprising MMP14 suppressing material; and a cell cultivation substrate comprising collagen that has been treated with MMP14.
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7.发明公开COMPOSITION FOR REGENERATNG NORMAL TISSUE FROM FIBROTIC TISSUE 有权ZUSAMMENSETZUNG ZUR WIEDERGEWINNON VON NORMALEM AUS FIBROTISCHEM GEWEBE
公开(公告)号：EP2601971A4
公开(公告)日：2014-01-08
申请号：EP11814740
申请日：2011-08-05
申请人： NITTO DENKO CORP
IPC分类号： A61K31/41 , A61K9/00 , A61K9/127 , A61K31/55 , A61K31/713 , A61K45/06 , A61K47/10 , A61K47/12 , A61K48/00 , A61P43/00
CPC分类号： C12N15/113 , A61K9/0019 , A61K9/1272 , A61K31/41 , A61K31/55 , A61K31/713 , A61K45/06 , C12N2310/14 , C12N2320/31 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition and a method for regenerating normal tissue from fibrotic tissue, the pharmaceutical composition and the method employing a collagen-reducing substance. In accordance with the present invention, normal tissue can be therapeutically regenerated from fibrotic tissue.
摘要翻译： 本发明涉及从纤维组织再生正常组织的药物组合物和方法，该药物组合物和使用胶原减少物质的方法。 根据本发明，可以从纤维组织治疗性地再生正常组织。
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公开(公告)号：EP2724729A4
公开(公告)日：2015-04-15
申请号：EP11868386
申请日：2011-06-21
申请人： NITTO DENKO CORP
发明人： NIITSU YOSHIRO , NISHITA HIROKI
IPC分类号： A61K45/06 , A61K31/52 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K38/45 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C12N15/113
CPC分类号： A61K31/713 , A61K31/52 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K38/45 , A61K45/06 , C12N15/1137 , C12N2310/14 , C12Y205/01018 , A61K2300/00
摘要： This invention relates to: a novel use of GST-À and GST-À suppressing agents; an apoptosis-inducing agent containing as active components a drug that suppresses GST-À and a drug that suppresses autophagy; a medical composition containing said agent; and a method using said medical composition for treating diseases associated with abnormal apoptosis.
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公开(公告)号：EP2509991A4
公开(公告)日：2013-05-22
申请号：EP10836656
申请日：2010-12-08
发明人： JIN XIAOMEI , YU LEI , TAKAHASHI HIROKAZU , TANAKA YASUNOBU , NIITSU YOSHIRO , FEINSTEIN ELENA , AVKIN-NACHUM SHARON , KALINSKI HAGAR , METT IGOR , ERLICH SHAI , SQUIERS ELIZABETH C , CHEN NING
IPC分类号： C07H21/00 , A61K31/7088
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/33 , C12N2310/531 , C12N2320/30 , C12N2310/3521
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公开(公告)号：EP2338519A4
公开(公告)日：2012-10-31
申请号：EP09811296
申请日：2009-09-04
申请人： NITTO DENKO CORP
发明人： NIITSU YOSHIRO , MATSUNAGA TAKUYA
IPC分类号： A61K47/10 , A61K9/127 , A61K31/7105 , A61K45/00 , A61K48/00 , A61P7/00 , A61P19/00 , A61P43/00 , C12N15/11
CPC分类号： C12N15/113 , A61K9/1272 , A61K31/07 , A61K31/7105 , A61K45/06 , A61K47/551 , A61K47/6911 , C12N15/111 , C12N2310/14 , C12N2320/32 , A61K2300/00
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