公开(公告)号：EP2049517B1

公开(公告)日：2013-11-27

申请号：EP07786158.1

申请日：2007-07-18

申请人： Novartis AG

发明人： IMASE, Hidetomo ,  IWAKI, Yuki ,  KAWANAMI, Toshio ,  MIYAKE, Takahiro ,  MOGI, Muneto ,  OHMORI, Osamu ,  QIN, Hongbo ,  UMEMURA, Ichiro ,  YAMADA, Ken ,  YASOSHIMA, Kayo

IPC分类号： C07D401/12 ,  C07D311/30 ,  A61K31/455 ,  A61P9/00 ,  C07D211/58 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

CPC分类号： C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

公开(公告)号：EP2229356A1

公开(公告)日：2010-09-22

申请号：EP08857355.5

申请日：2008-12-01

申请人： Novartis AG

发明人： MOGI, Muneto ,  KAWANAMI, Toshio ,  YAMADA, Ken ,  YASOSHIMA, Kayo ,  IMASE, Hidetomo ,  MIYAKE, Takahiro ,  OHMORI, Osamu

IPC分类号： C07D207/14 ,  C07D403/12 ,  C07D403/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/40 ,  A61P3/06

CPC分类号： C07D207/14 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.

公开(公告)号：EP1968941A1

公开(公告)日：2008-09-17

申请号：EP06829878.5

申请日：2006-12-27

申请人： Novartis AG

发明人： SAKAKI, Junichi ,  KISHIDA, Masashi ,  MATSUURA, Naoko ,  UMEMURA, Ichiro ,  KAWAHARA, Eiji ,  YAMADA, Ken ,  KONISHI, Kazuhide ,  IWAKI, Yuki ,  IMASE, Hidetomo ,  MIYAKE, Takahiro

IPC分类号： C07D213/38 ,  C07D213/40 ,  C07D401/12 ,  A61K31/44 ,  A61K31/4439 ,  A61P3/00 ,  A61P9/00

CPC分类号： C07D401/12 ,  C07D213/74 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables are as defined, useful as inhibitors of chlosteryl ester transfer protein.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中变量如所定义，可用作氯代酯转移蛋白的抑制剂。

公开(公告)号：EP1660458A1

公开(公告)日：2006-05-31

申请号：EP04764093.3

申请日：2004-08-13

申请人： Novartis AG ,  Novartis Pharma GmbH ,  IRM LLC

发明人： GARCIA-ECHEVERRIA, Carlos ,  KANAZAWA, Takanori ,  KAWAHARA, Eiji ,  MASUYA, Keiichi ,  MATSUURA, Naoko ,  MIYAKE, Takahiro ,  OHMORI, Osamu ,  UMEMURA, Ichiro ,  STEENSMA, Ruo ,  CHOPIUK, Greg ,  JIANG, Jiqing ,  WAN, Yongqin ,  DING, Qiang ,  ZHANG, Qiong ,  GRAY, Nathanael, Schiander ,  KARANEWSKY, Donald

IPC分类号： C07D239/48 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61K35/00 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07D239/48 ,  C04B35/632 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14

摘要： Novel pyrimidine derivatives of formula (I) Wherein R is selected from C16-10 aryl, C5-10heteroaryl, C3-12cycloalkyl and C3-10heterocycloalkyl; R0-R6 as described herein; and their use for the manufacture of a medicament for the treatment or prevention of a disease wich responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR.

公开(公告)号：EP2049517A1

公开(公告)日：2009-04-22

申请号：EP07786158.1

申请日：2007-07-18

申请人： NOVARTIS AG

发明人： IMASE, Hidetomo ,  IWAKI, Yuki ,  KAWANAMI, Toshio ,  MIYAKE, Takahiro ,  MOGI, Muneto ,  OHMORI, Osamu ,  QIN, Hongbo ,  UMEMURA, Ichiro ,  YAMADA, Ken ,  YASOSHIMA, Kayo

IPC分类号： C07D401/12 ,  C07D311/30 ,  A61K31/455 ,  A61P9/00 ,  C07D211/58 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

CPC分类号： C07D211/58 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention provides a compound of formula (I), wherein the variants R1, R2, R3, R4, R5, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.

摘要翻译： 本发明提供了式（I）化合物，其中变体R1，R2，R3，R4，R5，R6，R7如本文所定义，并且其中所述化合物是CETP的抑制剂，因此可用于 治疗由CETP介导的或响应于CETP抑制的病症或疾病。

公开(公告)号：EP1660458B1

公开(公告)日：2012-01-25

申请号：EP04764093.3

申请日：2004-08-13

申请人： Novartis AG ,  IRM LLC

发明人： GARCIA-ECHEVERRIA, Carlos ,  KANAZAWA, Takanori ,  KAWAHARA, Eiji ,  MASUYA, Keiichi ,  MATSUURA, Naoko ,  MIYAKE, Takahiro ,  OHMORI, Osamu ,  UMEMURA, Ichiro ,  STEENSMA, Ruo ,  CHOPIUK, Greg ,  JIANG, Jiqing ,  WAN, Yongqin ,  DING, Qiang ,  ZHANG, Qiong ,  GRAY, Nathanael, Schiander ,  KARANEWSKY, Donald

IPC分类号： C07D239/48 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61K35/00 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07D239/48 ,  C04B35/632 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14

摘要： Novel pyrimidine derivatives of formula (I) Wherein R is selected from C16-10 aryl, C5-10heteroaryl, C3-12cycloalkyl and C3-10heterocycloalkyl; R0-R6 as described herein; and their use for the manufacture of a medicament for the treatment or prevention of a disease wich responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR.

公开(公告)号：EP1606265B1

公开(公告)日：2011-02-02

申请号：EP04719989.8

申请日：2004-03-12

申请人： Novartis AG

发明人： .GARCIA-ECHEVERRIA, Carlos ,  KANAZAWA, Takanori ,  KAWAHARA, Eiji ,  MASUYA, Keiichi ,  MATSUURA, Naoko ,  MIYAKE, Takahiro ,  OHMORI, Osamu ,  UMEMURA, Ichiro

IPC分类号： C07D239/48 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61K35/00 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07D401/12 ,  C07D239/48 ,  C07D401/14

摘要： Novel pyrimidine derivatives of formula (I), to processes for their production, their use as pharmaceuticals in the treatment of neoplastic diseases, inflammatory and immune system disorders and to pharmaceutical compositions comprising them.

公开(公告)号：EP1601677A1

公开(公告)日：2005-12-07

申请号：EP04715273.1

申请日：2004-02-27

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： IRIE, Osamu ,  IWASAKI, Genji ,  MASUYA, Keiichi ,  MIYAKE, Takahiro ,  TENO, Naoki

IPC分类号： C07D487/04 ,  A61P29/00 ,  A61K31/00

CPC分类号： C07D519/00

摘要： The invention provides compounds of formula (I) or a pharmaceutically acceptable salt or ester thereof formula (I) wherein the symbols have the meaning as defined in the description. Said compounds are inhibitors of cathepsin K and/or cathepsin S and are useful for the treatment of diseases and medical conditions in which cathepsin K and/or cathepsin S is implicated, e.g. various disorders including neuropathic pain, inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis, multiple sclerosis and tumours.

公开(公告)号：EP2229356B1

公开(公告)日：2011-10-12

申请号：EP08857355.5

申请日：2008-12-01

申请人： Novartis AG

发明人： MOGI, Muneto ,  KAWANAMI, Toshio ,  YAMADA, Ken ,  YASOSHIMA, Kayo ,  IMASE, Hidetomo ,  MIYAKE, Takahiro ,  OHMORI, Osamu

IPC分类号： C07D207/14 ,  C07D403/12 ,  C07D403/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/40 ,  A61P3/06

CPC分类号： C07D207/14 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

摘要： The present invention provides a compound of formula (I): wherein the variants R1, R2, R3, R4, R6, R7 are as defined herein, and wherein said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.

公开(公告)号：EP1601677B1

公开(公告)日：2006-06-28

申请号：EP04715273.1

申请日：2004-02-27

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： IRIE, Osamu ,  IWASAKI, Genji ,  MASUYA, Keiichi ,  MIYAKE, Takahiro ,  TENO, Naoki

IPC分类号： C07D487/04 ,  A61P29/00 ,  A61K31/00

CPC分类号： C07D519/00

摘要： The invention provides compounds of formula (I) or a pharmaceutically acceptable salt or ester thereof formula (I) wherein the symbols have the meaning as defined in the description. Said compounds are inhibitors of cathepsin K and/or cathepsin S and are useful for the treatment of diseases and medical conditions in which cathepsin K and/or cathepsin S is implicated, e.g. various disorders including neuropathic pain, inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis, multiple sclerosis and tumours.