-
公开(公告)号：EP2007788A2
公开(公告)日：2008-12-31
申请号：EP07781535.5
申请日：2007-04-09
申请人： NOVARTIS AG , Novartis Pharma GmbH
发明人： COTTENS, Sylvain , EHRHARDT, Claus , FU, Jiping , PARKER, David Thomas , PATANE, Michael , RADETICH, Branko , RAMAN, Prakash , RANDL, Stefan Andreas , RIGOLLIER, Pascal , SEEPERSAUD, Mohindra , SIMIC, Oliver , WAN, Dongpeng
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
-
公开(公告)号：EP2007789B1
公开(公告)日：2015-05-20
申请号：EP07811837.9
申请日：2007-04-09
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BRANDL, Trixi , FU, Jiping , LENOIR, Francois , PARKER, David Thomas , PATANE, Michael , RADETICH, Branko , RAMAN, Prakash , RIGOLLIER, Pascal , SEEPERSAUD, Mohindra , SIMIC, Oliver , YIFRU, Aregahegn , ZHENG, Rui
IPC分类号： C07K5/078 , C07K5/083 , C07K5/087 , C07K5/103 , C07K5/107 , A61K38/05 , A61P31/14 , C07D401/12 , C07D403/12 , C07D409/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/10 , C07D209/96 , C07K5/065 , C07K5/062
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
-
公开(公告)号：EP2007787A2
公开(公告)日：2008-12-31
申请号：EP07781534.8
申请日：2007-04-09
申请人： NOVARTIS AG , Novartis Pharma GmbH
发明人： BRANDL, Trixi , BRITT, Shawn D. , COTTENS, Sylvain , EHRHARDT, Claus , FU, Jiping , KARUR, Subramanian , LI, Hongju , LU, Peichao , PARKER, David Thomas , PATANE, Michael , RADETICH, Branko , RAMAN, Prakash , RANDL, Stefan Andreas , RIGOLLIER, Pascal , SEEPERSAUD, Mohindra , SIMIC, Oliver , TICHKULE, Ritesh Bhanudasji , ZHU, Yanyi
CPC分类号： C07K5/1016 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C12N2770/24211
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
-
公开(公告)号：EP2007789A2
公开(公告)日：2008-12-31
申请号：EP07811837.9
申请日：2007-04-09
发明人： BRANDL, Trixi , FU, Jiping , LENOIR, Francois , PARKER, David Thomas , PATANE, Michael , RADETICH, Branko , RAMAN, Prakash , RIGOLLIER, Pascal , SEEPERSAUD, Mohindra , SIMIC, Oliver , YIFRU, Aregahegn , ZHENG, Rui
IPC分类号： C07K5/06 , C07K5/078 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/10 , C07K5/103 , C07K5/107 , A61K38/05 , A61K38/06 , A61K38/07 , A61P31/12 , A61P31/14 , A61P31/18
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
摘要： The present application describes organic compounds of formula (I): that are useful for the treatment, prevention and/or amelioration of human diseases such as HCV and HIV.
-
公开(公告)号：EP1896452A2
公开(公告)日：2008-03-12
申请号：EP06770806.5
申请日：2006-05-22
发明人： BRACKEN, Kathryn Rene , BUSHELL, Simon , DEAN, Karl , FRANCAVILLA, Charles , JAIN, Rakesh K. , LEE, Kwangho , SEEPERSAUD, Mohindra , SHU, Lei , SUNDARAM, Arathia , YUAN, Zhengyu
IPC分类号： C07D401/12 , C07D403/12 , A61P31/04
CPC分类号： C07D401/12 , C07D403/12
摘要： Novel N-formyl hydroxylamine compounds (I) and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes . The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed. wherein R1 is hydrogen, alkyl, heteroalkyi, heterocycloalkyl, aryl or heteroaryl.; R3 is hydrogen, halogen, or alkoxy; R4 is aryl, or heteroaryl; or n is 0 to 3 and provided that R1 is cycloalkyl and/or R4 is an optionally substituted 6 membered, monocyclic heteroaryl ring having 2, 3 or 4 nitrogen heteroatoms in the ring wherein one or more of the ring nitrogen heteroatoms is optionally oxidized.
-
公开(公告)号：EP1896452B1
公开(公告)日：2011-11-16
申请号：EP06770806.5
申请日：2006-05-22
发明人： BRACKEN, Kathryn Rene , BUSHELL, Simon , DEAN, Karl , FRANCAVILLA, Charles , JAIN, Rakesh K. , LEE, Kwangho , SEEPERSAUD, Mohindra , SHU, Lei , SUNDARAM, Arathia , YUAN, Zhengyu
IPC分类号： C07D401/12 , C07D403/12 , A61P31/04
CPC分类号： C07D401/12 , C07D403/12
摘要： Novel N-formyl hydroxylamine compounds (I) and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes . The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed. wherein R1 is hydrogen, alkyl, heteroalkyi, heterocycloalkyl, aryl or heteroaryl.; R3 is hydrogen, halogen, or alkoxy; R4 is aryl, or heteroaryl; or n is 0 to 3 and provided that R1 is cycloalkyl and/or R4 is an optionally substituted 6 membered, monocyclic heteroaryl ring having 2, 3 or 4 nitrogen heteroatoms in the ring wherein one or more of the ring nitrogen heteroatoms is optionally oxidized.
-
公开(公告)号：EP2417108A1
公开(公告)日：2012-02-15
申请号：EP10722776.1
申请日：2010-04-09
申请人： Novartis AG
IPC分类号： C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/14 , A61K31/403 , A61P31/22 , C07K5/08
CPC分类号： C07K7/06 , A61K31/403 , A61K31/4439 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/14 , C07K5/06165 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/10 , C07K5/101 , C07K5/1016
摘要： The present application describes organic compounds of formula (I) that are useful for the treatment, prevention and/or amelioration of human diseases, in particular HCV.
-
8.发明公开
公开(公告)号：EP3887388A1
公开(公告)日：2021-10-06
申请号：EP19816906.2
申请日：2019-11-26
申请人： Novartis AG
-
公开(公告)号：EP2417108B1
公开(公告)日：2016-08-17
申请号：EP10722776.1
申请日：2010-04-09
申请人： Novartis AG
IPC分类号： C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/14 , A61K31/403 , A61P31/22 , C07K5/08
CPC分类号： C07K7/06 , A61K31/403 , A61K31/4439 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/14 , C07K5/06165 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/10 , C07K5/101 , C07K5/1016
-
10.发明公开
公开(公告)号：EP2205584A1
公开(公告)日：2010-07-14
申请号：EP08805142.0
申请日：2008-10-08
申请人： Novartis AG
发明人： BRITT, Shawn, D. , CISZEWSKI, Lech, Andrzej , FU, Jiping , KARUR, Subramanian , LIU, Yugang , PARKER, David Thomas , PRASHAD, Mahavir , RAMAN, Prakash , SEEPERSAUD, Mohindra , ZHENG, Rui , LU, Peichao , RIGOLLIER, Pascal , YIFRU, Aregahegn
IPC分类号： C07D401/12 , C07D403/12 , A61K31/403 , A61K31/44 , A61K31/497 , A61P31/12
CPC分类号： C07D401/12 , C07D403/12 , C07K5/0812 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.023 秒)
