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公开(公告)号：EP2007789B1
公开(公告)日：2015-05-20
申请号：EP07811837.9
申请日：2007-04-09
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BRANDL, Trixi , FU, Jiping , LENOIR, Francois , PARKER, David Thomas , PATANE, Michael , RADETICH, Branko , RAMAN, Prakash , RIGOLLIER, Pascal , SEEPERSAUD, Mohindra , SIMIC, Oliver , YIFRU, Aregahegn , ZHENG, Rui
IPC分类号： C07K5/078 , C07K5/083 , C07K5/087 , C07K5/103 , C07K5/107 , A61K38/05 , A61P31/14 , C07D401/12 , C07D403/12 , C07D409/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/10 , C07D209/96 , C07K5/065 , C07K5/062
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
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2.发明公开CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES 审中-公开CARXOXYAMIN组合物以及它们在HDAC依赖性疾病的治疗
公开(公告)号：EP1996550A2
公开(公告)日：2008-12-03
申请号：EP06804134.2
申请日：2006-09-25
申请人： NOVARTIS AG , Novartis Pharma GmbH
发明人： DOBLER, Marcus, Rolf , GROB, Jonathan, E. , PATNAIK, Anup , RADETICH, Branko , SHULTZ, Michael , ZHU, Yanyi
IPC分类号： C07D211/44 , C07D211/70 , C07D209/44 , C07D221/20 , C07D295/185 , C07D295/192 , C07D401/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/10 , A61K31/4162 , A61K31/438 , A61K31/445 , A61K31/472
CPC分类号： C07D209/44 , C07D211/44 , C07D211/70 , C07D221/20 , C07D295/185 , C07D295/192 , C07D401/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/10
摘要： The invention relates to the use of carboxyamine compounds and salts thereof in the treatment of HDAC dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases.
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公开(公告)号：EP2007787A2
公开(公告)日：2008-12-31
申请号：EP07781534.8
申请日：2007-04-09
申请人： NOVARTIS AG , Novartis Pharma GmbH
发明人： BRANDL, Trixi , BRITT, Shawn D. , COTTENS, Sylvain , EHRHARDT, Claus , FU, Jiping , KARUR, Subramanian , LI, Hongju , LU, Peichao , PARKER, David Thomas , PATANE, Michael , RADETICH, Branko , RAMAN, Prakash , RANDL, Stefan Andreas , RIGOLLIER, Pascal , SEEPERSAUD, Mohindra , SIMIC, Oliver , TICHKULE, Ritesh Bhanudasji , ZHU, Yanyi
CPC分类号： C07K5/1016 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C12N2770/24211
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
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公开(公告)号：EP2007788A2
公开(公告)日：2008-12-31
申请号：EP07781535.5
申请日：2007-04-09
申请人： NOVARTIS AG , Novartis Pharma GmbH
发明人： COTTENS, Sylvain , EHRHARDT, Claus , FU, Jiping , PARKER, David Thomas , PATANE, Michael , RADETICH, Branko , RAMAN, Prakash , RANDL, Stefan Andreas , RIGOLLIER, Pascal , SEEPERSAUD, Mohindra , SIMIC, Oliver , WAN, Dongpeng
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
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公开(公告)号：EP2007789A2
公开(公告)日：2008-12-31
申请号：EP07811837.9
申请日：2007-04-09
发明人： BRANDL, Trixi , FU, Jiping , LENOIR, Francois , PARKER, David Thomas , PATANE, Michael , RADETICH, Branko , RAMAN, Prakash , RIGOLLIER, Pascal , SEEPERSAUD, Mohindra , SIMIC, Oliver , YIFRU, Aregahegn , ZHENG, Rui
IPC分类号： C07K5/06 , C07K5/078 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/10 , C07K5/103 , C07K5/107 , A61K38/05 , A61K38/06 , A61K38/07 , A61P31/12 , A61P31/14 , A61P31/18
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
摘要： The present application describes organic compounds of formula (I): that are useful for the treatment, prevention and/or amelioration of human diseases such as HCV and HIV.
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公开(公告)号：EP2125757A1
公开(公告)日：2009-12-02
申请号：EP08707770.7
申请日：2008-02-19
申请人： Novartis AG
发明人： BRITT, Shawn, D. , FU, Jiping , PARKER, David, Thomas , PATANE, Michael A. , RAMAN, Prakash , RADETICH, Branko , SEEPERSAUD, Mohindra , YIFRU, Aregahegn , ZHENG, Rui , BRANDL, Trixi , COTTENS, Sylvain , EHRHARDT, Claus , RANDL, Stefan, Andreas , RIGOLLIER, Pascal , SCHIERING, Nikolaus , SIMIC, Oliver
IPC分类号： C07D257/02 , C07D285/00 , C07D487/04 , C07D487/08 , C07D498/04 , C07D513/04 , C07D515/04 , C07D519/00 , A61K31/395 , A61P31/14 , C07K5/02
CPC分类号： C07D513/04 , C07D257/02 , C07D285/00 , C07D487/04 , C07D487/08 , C07D498/04 , C07D515/04 , C07D519/00 , C07K5/0202 , C07K5/0207 , C07K5/0804 , C07K5/0827 , C07K5/1008 , C07K5/1024
摘要： The present application describes macrocyclic compounds of formula (I) with NS3 protease inhibitory activity for treating hepatitis C virus infection.
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公开(公告)号：EP2670753B1
公开(公告)日：2016-10-19
申请号：EP12704135.8
申请日：2012-01-30
申请人： Novartis AG
发明人： RADETICH, Branko , YU, Bing , ZHU, Yanyi
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5377 , C07D519/00
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公开(公告)号：EP2670753A1
公开(公告)日：2013-12-11
申请号：EP12704135.8
申请日：2012-01-30
申请人： Novartis AG
发明人： RADETICH, Branko , YU, Bing , ZHU, Yanyi
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5377 , C07D519/00
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, to their preparation, to their medical use, in particular to their use in the treatment of cancer and neurodegenerative disorders, and to medicaments comprising them.
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公开(公告)号：EP2771342B1
公开(公告)日：2016-05-18
申请号：EP12798854.1
申请日：2012-10-26
申请人： Novartis AG
发明人： BRIARD, Emmanuelle , FURET, Pascal , LERCHNER, Andreas , MEIER, Peter , RADETICH, Branko , SANDHAM, David Andrew , ZHU, Yanyi
IPC分类号： C07D473/16 , C07D519/00
CPC分类号： C07D473/16 , A61K31/5377 , A61K31/553 , C07D487/04 , C07D491/048 , C07D491/107 , C07D519/00
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公开(公告)号：EP2771342A1
公开(公告)日：2014-09-03
申请号：EP12798854.1
申请日：2012-10-26
申请人： Novartis AG
发明人： BRIARD, Emmanuelle , FURET, Pascal , LERCHNER, Andreas , MEIER, Peter , RADETICH, Branko , SANDHAM, David Andrew , ZHU, Yanyi
IPC分类号： C07D473/16 , C07D519/00
CPC分类号： C07D473/16 , A61K31/5377 , A61K31/553 , C07D487/04 , C07D491/048 , C07D491/107 , C07D519/00
摘要： The invention relates to PI3K inhibitors of the formula (I) • in which all of the variables are as defined in the specification, to their preparation, to their medical use, in particular to their use in the treatment of cancer and neurodegenerative disorders, and to medicaments comprising them.
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