公开(公告)号：EP1531815B1

公开(公告)日：2014-09-24

申请号：EP03761446.8

申请日：2003-06-27

申请人： NOVO NORDISK A/S ,  TransTech Pharma, LLC

发明人： POLISETTI, Dharma, Rao ,  KODRA, János, Tibor ,  LAU, Jesper ,  BLOCH, Paw ,  VALCARCE-LOPEZ,Maria,Carmen, ,  BLUME, Niels ,  GUZEL, Mustafa ,  SANTHOSH, Kalpathy, Chidambareswaran ,  MJALLI, Adnan, M., M. ,  ANDREWS, Robert, Carl ,  SUBRAMANIAN, Govindan ,  ANKERSEN, Michael ,  VEDSOE, Per ,  MURRAY, Anthony ,  JEPPESEN, Lone ,  LAU, Jesper

IPC分类号： A61K31/433 ,  A61P3/10 ,  A61P3/06 ,  A61P3/04 ,  C07D277/48 ,  C07D277/52 ,  C07D213/75 ,  C07D417/12 ,  C07D277/56 ,  C07D417/06 ,  C07D417/14 ,  C07D285/16 ,  C07D487/04 ,  C07D277/54

CPC分类号： C07D277/38 ,  A61K31/426 ,  A61K31/427 ,  A61K31/454 ,  A61K31/55 ,  A61K45/06 ,  C07D213/75 ,  C07D277/46 ,  C07D277/48 ,  C07D277/52 ,  C07D277/54 ,  C07D277/56 ,  C07D285/135 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D473/38

公开(公告)号：EP1723128A1

公开(公告)日：2006-11-22

申请号：EP05700554.8

申请日：2005-01-06

申请人： NOVO NORDISK A/S

发明人： MURRAY, Anthony ,  LAU, Jesper ,  JEPPESEN, Lone ,  VEDSO , Per ,  ANKERSEN, Michael ,  LUNDBECK, Jane, Marie ,  KRISTIANSEN, Marit ,  VALCARCE-LOPEZ, Maria Carmen ,  POLISETTI, Dharma, Rao ,  SUBRAMANIAN, Govindan ,  ANDREWS, Robert, Carl ,  CHRISTEN, Daniel, P. ,  COOPER, Jeremy, T. ,  SANTHOSH, Kalpathy, Chidambareswaran

IPC分类号： C07D277/48 ,  C07D277/56 ,  C07D285/12 ,  C07D277/82 ,  C07D241/20 ,  C07D285/08 ,  C07D277/60 ,  C07D213/75 ,  C07D233/88 ,  C07D271/08 ,  C07D261/14 ,  C07D417/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14

CPC分类号： C07D417/12 ,  A61K31/4168 ,  A61K31/427 ,  A61K31/433 ,  C07D213/75 ,  C07D233/88 ,  C07D241/20 ,  C07D261/14 ,  C07D271/08 ,  C07D277/48 ,  C07D277/56 ,  C07D277/60 ,  C07D277/82 ,  C07D285/08 ,  C07D285/135 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D513/04

摘要： This invention relates to compounds that are of formula (I) wherein A is heteroaryl and R1 and R2 are both cyclic residues, that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial .

公开(公告)号：EP0805816B1

公开(公告)日：2004-07-28

申请号：EP96900550.3

申请日：1996-01-26

申请人： NOVO NORDISK A/S

发明人： LAU, Jesper ,  PESCHKE, Bernd ,  HANSEN, Thomas, Kruse ,  JOHANSEN, Nils, Langeland ,  ANKERSEN, Michael

IPC分类号： C07K5/02 ,  A61K38/05 ,  A61K38/06

CPC分类号： C07D271/06 ,  A61K38/00 ,  C07C233/38 ,  C07C237/22 ,  C07C237/32 ,  C07C237/36 ,  C07D211/62 ,  C07D271/10 ,  C07D277/56 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07K14/60

摘要： There are disclosed novel synthetic peptides of general formula (I), where the abbreviations A, B, D, E, F, G, J and m, n, p are further defined in the description. Compounds of formula (I) promote the release of growth hormone in humans and animals. Growth promoting compositions containing such compounds of formula (I) as the active ingredient thereof, methods of stimulating the release of growth hormone as well as use of such compounds of formula (I) are also disclosed.

公开(公告)号：EP1019050A1

公开(公告)日：2000-07-19

申请号：EP98929232.1

申请日：1998-06-22

申请人： NOVO NORDISK A/S

发明人： ANKERSEN, Michael ,  STIDSEN, Carsten, Enggaard ,  CRIDER, Michael, Albert

IPC分类号： A61K31/44 ,  C07D401/12 ,  C07D213/74 ,  C07D413/12

CPC分类号： C07D213/74 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12

摘要： The invention relates to the use of a somatostatin receptor ligand of nonpeptide origin, e.g. of general formula (Ia) or (Ib) or a pharmaceutically acceptable salt thereof, which has high and/or selective affinity to the somatostatin receptor protein designated SSTR4, for the preparation of a medicament for the treatment of a disease associated with an adverse condition in the retina and/or iris-ciliary body of a mammal. Such conditions being high intraocular pressure (IOP) and/or deep ocular infections. The diseases which may be treated are e.g. glaucoma, stromal keratitis, iritis, retinitis, cataract and conjunctivitis.

公开(公告)号：EP0912551A1

公开(公告)日：1999-05-06

申请号：EP97921646.0

申请日：1997-05-14

申请人： NOVO NORDISK A/S

发明人： ANKERSEN, Michael ,  STIDSEN, Carsten, Enggaard ,  ANDERSEN, Henrik, Sune

IPC分类号： C07D215 ,  A61K31 ,  A61P1 ,  A61P5 ,  A61P9 ,  A61P35 ,  A61P43 ,  C07D213 ,  C07D401

CPC分类号： C07D213/74 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/12

摘要： The present invention relates to somatostatin ligands (Ia) or (Ib) which are useful for treating medical disorders related to binding to human somatostatin receptor subtypes, wherein X is =S, =O, =NH, =NCOPh or =N(CN), A is aryl optionally substituted with halogen, amino, hydroxy, nitro, C1-6-alkyl, C1-6-alkoxy or aryl, B is aryl optionally substituted with halogen, amino, hydroxy, C1-6-alkyl, C1-6-alkoxy or aryl, D is aryl, amino, optionally substituted with halogen, amino, hydroxy, C1-6-alkyl, C1-6-alkoxy or aryl, or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP1723128B1

公开(公告)日：2012-11-07

申请号：EP05700554.8

申请日：2005-01-06

申请人： NOVO NORDISK A/S ,  TransTech Pharma, Inc

发明人： MURRAY, Anthony ,  LAU, Jesper ,  JEPPESEN, Lone ,  VEDSO , Per ,  ANKERSEN, Michael ,  LUNDBECK, Jane, Marie ,  KRISTIANSEN, Marit ,  VALCARCE-LOPEZ, Maria Carmen ,  POLISETTI, Dharma, Rao ,  SUBRAMANIAN, Govindan ,  ANDREWS, Robert, Carl ,  CHRISTEN, Daniel, P. ,  COOPER, Jeremy, T. ,  SANTHOSH, Kalpathy, Chidambareswaran

IPC分类号： C07D277/48 ,  C07D417/12 ,  A61K31/14 ,  A61K31/426 ,  A61P3/10

CPC分类号： C07D417/12 ,  A61K31/4168 ,  A61K31/427 ,  A61K31/433 ,  C07D213/75 ,  C07D233/88 ,  C07D241/20 ,  C07D261/14 ,  C07D271/08 ,  C07D277/48 ,  C07D277/56 ,  C07D277/60 ,  C07D277/82 ,  C07D285/08 ,  C07D285/135 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D513/04

公开(公告)号：EP1100824B1

公开(公告)日：2011-03-02

申请号：EP99929114.9

申请日：1999-06-29

申请人： NOVO NORDISK A/S

发明人： PESCHKE, Bernd ,  RICHTER, Stefan, Lutz ,  HANSEN, Thomas, Kruse ,  ANKERSEN, Michael

IPC分类号： C07K14/60 ,  C07K5/02 ,  C07K5/06 ,  A61K38/05 ,  A61K38/25

CPC分类号： C07K5/0207 ,  A61K38/00

摘要： The invention relates to novel compounds, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone.

公开(公告)号：EP1689392A1

公开(公告)日：2006-08-16

申请号：EP04797475.3

申请日：2004-11-24

申请人： NOVO NORDISK A/S

发明人： LAU, Jesper F ,  VEDSO , Per ,  KODRA, János Tibor ,  MURRAY, Anthony ,  JEPPESEN, Lone ,  ANKERSEN, Michael ,  SUBRAMANIAN, Govindan ,  MJALLI, Adnan M. M. ,  ANDREWS, Robert Carl ,  POLISETTI, Dharma Rao ,  CHRISTEN, Daniel Peter

IPC分类号： A61K31/427 ,  A61P3/06 ,  A61P3/10 ,  C07D417/12 ,  C07D401/12 ,  C07D491/04 ,  C07D403/12

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D491/04

摘要： This invention relates to compounds that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial, such as diabetes. The compounds are of the general formula (I) wherein B is (X) and A is heteroaryl as defined in the claims.

公开(公告)号：EP1200111A1

公开(公告)日：2002-05-02

申请号：EP00931042.6

申请日：2000-05-31

申请人： NOVO NORDISK A/S

发明人： ANKERSEN, Michael

IPC分类号： A61K38/08 ,  A61K38/24 ,  A61P3/00

CPC分类号： A61K38/07 ,  A61K38/066 ,  A61K38/08 ,  A61K2300/00

摘要： Compositions comprising TRH and a compound of the general formula A-B-C-D(-E)p are used for treating the catabolic state of prolonged critical illness.

摘要翻译： 包含TRH和通式A-B-C-D（-E）p的化合物的组合物用于治疗长时间危重疾病的分解代谢状态。

公开(公告)号：EP1005484A1

公开(公告)日：2000-06-07

申请号：EP98929229.7

申请日：1998-06-12

申请人： NOVO NORDISK A/S

发明人： HANSEN, Thomas, Kruse ,  LAU, Jesper ,  PESCHKE, Bernd ,  ANKERSEN, Michael ,  MADSEN, Kjeld ,  JOHANSEN, Nils, Langeland

IPC分类号： C07K5/08 ,  C07K5/10 ,  C07K7/02 ,  C07K14/60 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/0207 ,  C07K5/0827

摘要： Compounds of general formula (I), compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone.