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1.发明公开DETERGENT CONTAINING PROTEASE AND INHIBITOR AND NOVEL INHIBITORS FOR USE THEREIN 失效蛋白酶和抑制剂含清洁剂和新的抑制剂在其中的用途。
公开(公告)号：EP0549675A1
公开(公告)日：1993-07-07
申请号：EP91916862.0
申请日：1991-09-18
申请人： NOVO NORDISK A/S
CPC分类号： C12N9/54 , C07K14/811 , C11D3/386
摘要： Composition détersive contenant une protéase ainsi qu'un inhibiteur de protéase réversible du type peptidique ou protéinique, dans laquelle le rapport entre la constante de dissociation et la concentration de protéase se situe dans une plage allant de 0,006 à 6. Lorsque la protéase est de la subtilisine, l'inhibiteur de protéase est de préférence un inhibiteur de subtilisine modifiée de la Famille VI.
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公开(公告)号：EP0652899A1
公开(公告)日：1995-05-17
申请号：EP93914657.0
申请日：1993-07-09
申请人： NOVO NORDISK A/S
发明人： PEDERSEN, Anders Hjelholt , HALKIER, Torben , NIELSEN, Birte, Annette , LANGE, Lene , MIKKELSEN, Jan, Moeller , RASMUSSEN, Grethe , HANSEN, Mogens, Trier
摘要： A DNA construct comprising a DNA sequence encoding an antifungal polypeptide, which sequence comprises the nucleotide sequence shown in SEQ ID No. 1 or an analogue thereof, which i) hybridizes with a DNA sequence comprising the nucleotide sequence shown in SEQ ID No. 1, or with a probe hybridizing with the nucleotide sequence SEQ ID No. 1, ii) encodes a polypeptide which reacts with an antibody reactive with at least one epitope of the polypeptide having the amino acid sequence shown in SEQ ID No. 2, and/or iii) encodes a polypeptide having the amino acid sequence shown in the appended SEQ ID No. 2 or a sequence homologous thereto, provided that the DNA sequence is different from one which encodes the polypeptide having the amino acid sequence shown in SEQ ID No. 2 except for an asparagine in position 4, an alanine in position 24, a lysine in position 32, a phenylalanine in position 42 and a tyrosine in position 50. The antifungal polypeptide encoded by the DNA construct may be used for combating or controlling fungal infections, in particular on plants.
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公开(公告)号：EP0631585A1
公开(公告)日：1995-01-04
申请号：EP93901661.0
申请日：1992-12-11
申请人： NOVO NORDISK A/S
发明人： JOERGENSEN, Per, Linaa , PEDERSEN, Poul, Erik , PETERSEN, Joergen , NIELSEN, Torben, K. , MIKKELSEN, Jan, Moeller
摘要： A process for the microbial production of a protein susceptible to inactivation in a fluid production medium by constinuously and reversibly protecting said protein against said inactivation during the production stage, separating the protein from the production medium, deprotecting the protein, and recovering the protein product. The process is especially useful for obtaining substantially increased yields of the protein in question by continuously precipitating said protein.
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公开(公告)号：EP0631585B1
公开(公告)日：1998-09-30
申请号：EP93901661.4
申请日：1992-12-11
申请人： NOVO NORDISK A/S
发明人： JOERGENSEN, Per, Linaa , PEDERSEN, Poul, Erik , PETERSEN, Joergen , NIELSEN, Torben, K. , MIKKELSEN, Jan, Moeller
摘要： A process for the microbial production of a protein susceptible to inactivation in a fluid production medium by constinuously and reversibly protecting said protein against said inactivation during the production stage, separating the protein from the production medium, deprotecting the protein, and recovering the protein product. The process is especially useful for obtaining substantially increased yields of the protein in question by continuously precipitating said protein.
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5.发明授权DETERGENT CONTAINING PROTEASE AND INHIBITOR AND NOVEL INHIBITORS FOR USE THEREIN 失效蛋白酶和抑制剂含清洁剂和新的抑制剂在其中的用途。
公开(公告)号：EP0549675B1
公开(公告)日：1995-04-05
申请号：EP91916862.5
申请日：1991-09-18
申请人： NOVO NORDISK A/S
CPC分类号： C12N9/54 , C07K14/811 , C11D3/386
摘要： A detergent composition and additive comprising a protease and a reversible protease inhibitor of the peptide or protein type, wherein the ratio of the dissociation constant to the protease concentration in the range from 0.006 to 6. When the protease is subtilisin, the protease inhibitor is preferably a modified subtilisin inhibitor of Family VI.
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