公开(公告)号：EP0521977B1

公开(公告)日：1996-09-11

申请号：EP91906843.7

申请日：1991-03-27

申请人： NYCOMED IMAGING AS

发明人： BERG, Arne ,  ALMEN, Torsten ,  KRAUTWURST, Klaus, Dieter ,  KIM, Sook-Hui ,  RONGVED, Pal ,  KLAVENESS, Jo ,  DUGSTAD, Harald

IPC分类号： A61K49/04 ,  A61K49/00

CPC分类号： C07F11/005 ,  A61K49/04 ,  A61K51/02 ,  A61K51/04 ,  A61K51/0482 ,  A61K2123/00 ,  Y10S514/836

摘要： The invention relates to the use as contrast enhancing agents in medical imaging, especially X-ray imaging, of multinuclear complexes, i.e. complexes, such as those of W2O2(ν2O)2, in which the complexed entity comprises at least two contrast enhancing atoms.

公开(公告)号：EP0452392B1

公开(公告)日：1995-04-12

申请号：EP90901813.7

申请日：1990-01-15

申请人： NYCOMED IMAGING AS

发明人： ALMEN, Torsten ,  BERG, Arne ,  DUGSTAD, Harald ,  KLAVENESS, Jo ,  KRAUTWURST, Klaus, Dieter ,  RONGVED, Pal

IPC分类号： C07D211/46 ,  A61K49/00 ,  C07D265/30 ,  C07D207/12 ,  C07D241/04 ,  C07D279/12 ,  A61K51/00 ,  A61K49/04

CPC分类号： C07D211/56 ,  A61K47/54 ,  A61K47/547 ,  A61K49/06 ,  A61K51/0478 ,  A61K51/0482 ,  A61K2121/00 ,  A61K2123/00 ,  C07D207/14 ,  C07D241/04 ,  C07D265/30 ,  C07D279/12 ,  C07F3/003 ,  C07F5/003 ,  C07F9/94 ,  C07F13/005 ,  Y10S514/836 ,  Y10T436/24

摘要： There are provided heterocyclic chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents being compounds of formula (I) (wherein X represents a bond, an oxygen or sulphur atom or a group of formula CHR?1 or NR3¿; each R1 which may be the same or different represents a hydrogen atom, a group of formula OR?3 or NR3R3¿ or an alkyl or alkoxyalkyl group optionally substituted by a hydroxyl group or by a group of formula NR3R3 or CONR3R3; each R2 which may be the same or different represents a hydrogen atom or an alkyl or alkoxy group optionally substituted by a hydroxyl or alkoxy group; each R3 which may be the same or different represents a hydrogen atom, an optionally hydroxylated alkyl group or a group of formula CH¿2?Y; Y represents a group of formula COZ, CON(OH)R?4, POZ¿2 or SO2Z; Z represents a group of formula OR?4, Nr4R4¿ or (II) where each R11 which may be the same or different is a hydrogen atom, a hydroxyl group or an optionally hydroxylated alkyl group, s is 0, 1 or 2, and W is a group CHR?11, NR11¿ or an oxygen atom; and each R4 which may be the same or different represents a hydrogen atom or an optionally mono- or poly hydroxylated alkyl, alkoxyalkyl or polyalkoxyalkyl group; with the provisos that where s is 0 then W is a CHR11 group and that where X represents a bond or a group CHR1 at least one group R1 or R2 represents other than a hydrogen atom or an unsubstituted alkyl group) and chelate complexes and salts thereof.

公开(公告)号：EP0521977A1

公开(公告)日：1993-01-13

申请号：EP91906843.0

申请日：1991-03-27

申请人： NYCOMED IMAGING AS

发明人： BERG, Arne ,  ALMEN, Torsten ,  KRAUTWURST, Klaus, Dieter ,  KIM, Sook-Hui ,  RONGVED, Pal ,  KLAVENESS, Jo ,  DUGSTAD, Harald

IPC分类号： A61K ,  A61K49 ,  A61K51 ,  C07F11

CPC分类号： C07F11/005 ,  A61K49/04 ,  A61K51/02 ,  A61K51/04 ,  A61K51/0482 ,  A61K2123/00 ,  Y10S514/836

摘要： L'invention concerne l'utilisation, comme agents d'amélioration du contraste en imagerie médicale, notamment en radiographie, de complexes multinucléaires, c'est-à-dire de complexes tels que ceux de formule W2O2(mu2O)2, dans lesquels l'entité composite comprend au moins deux atomes améliorant le contraste.

摘要翻译： 本发明涉及多核配合物的医学成像尤其是放射线照相术中的对比增强剂，即配合物如式W 2 O 2（mu 2 O）2的配合物，其中 复合实体包括至少两个对比增强原子。