公开(公告)号：EP0877630A2

公开(公告)日：1998-11-18

申请号：EP97900316.0

申请日：1997-01-09

申请人： NYCOMED IMAGING AS

发明人： COCKBAIN, Julian ,  GUNTHER, Wolfgang ,  KELLAR, Kenneth ,  FUJII, Dennis, Kiyoshi ,  DESAI, Vinay ,  BLACK, Christopher ,  BEEBER, Marshall ,  WELLONS, Jennifer ,  FAHLVIK, Anne, Kjersti ,  NAEVESTAD, Anne ,  NA, George ,  YUAN, Barbara ,  STEVENS, Jack ,  WEEKLEY, Brian ,  ENGELL, Torgrim ,  GACEK, Michel ,  LADD, David, Lee ,  SINGH, Jasbir ,  BACON, Edward, Richard ,  McINTIRE, Gregory, Lynn ,  SNOW, Robert, Alan

IPC分类号： A61K49 ,  C01G49 ,  C08J3 ,  C08L3

CPC分类号： B82Y5/00 ,  A61K49/049 ,  A61K49/1842 ,  A61K49/186 ,  A61K49/1863

摘要： The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized polyalkyleneoxide which serves to prolong blood residence.