公开(公告)号：EP0973554A1

公开(公告)日：2000-01-26

申请号：EP98917352.1

申请日：1998-04-14

申请人： NYCOMED IMAGING AS

发明人： YU, Shi-Bao ,  SINGH, Jasbir ,  GOLDING, Louise

IPC分类号： A61K51/04 ,  A61K49/04 ,  A61K49/00

CPC分类号： A61K49/103 ,  A61K49/04 ,  A61K51/0478

摘要： The invention provides a complexant compound of formula (I): R3S(CR12)nN(R2)i(CR12)nX(CR12)nN(R2)i(CR12)nSR3, (wherein each n, which may be the same or different, is an integer 2, 3 or 4 (preferably 2); each i, which may be the same or different, represents 0 or 1; each R3, which may be the same or different, is H or a thiol protecting group, preferably a protecting group; X is O, S, N, NR4 or a substituted phosphorus (e.g. oxo substituted phosphorus), preferably S or N; each R4, which may be the same or different, is hydrogen or an optionally substituted organic group; each R2, which may be the same or different, is hydrogen or an optionally substituted organic group; each R1, which may be the same or different, is hydrogen or an optionally substituted organic group, or a moiety CR12 may represent a carbonyl group or two, three or four R1S on two different carbons together with those carbons and any intervening atoms may represent an optionally substituted saturated or unsaturated homocyclic or heterocyclic ring; and preferably, at least one CR12 moiety is other than CH2 or CH(CH3)) or a salt or complex thereof, wherein optionally at least one of the R?1, R2, R3 and R4¿ moieties is coupled directly or indirectly to a vector moiety.

公开(公告)号：EP0877630A2

公开(公告)日：1998-11-18

申请号：EP97900316.0

申请日：1997-01-09

申请人： NYCOMED IMAGING AS

发明人： COCKBAIN, Julian ,  GUNTHER, Wolfgang ,  KELLAR, Kenneth ,  FUJII, Dennis, Kiyoshi ,  DESAI, Vinay ,  BLACK, Christopher ,  BEEBER, Marshall ,  WELLONS, Jennifer ,  FAHLVIK, Anne, Kjersti ,  NAEVESTAD, Anne ,  NA, George ,  YUAN, Barbara ,  STEVENS, Jack ,  WEEKLEY, Brian ,  ENGELL, Torgrim ,  GACEK, Michel ,  LADD, David, Lee ,  SINGH, Jasbir ,  BACON, Edward, Richard ,  McINTIRE, Gregory, Lynn ,  SNOW, Robert, Alan

IPC分类号： A61K49 ,  C01G49 ,  C08J3 ,  C08L3

CPC分类号： B82Y5/00 ,  A61K49/049 ,  A61K49/1842 ,  A61K49/186 ,  A61K49/1863

摘要： The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized polyalkyleneoxide which serves to prolong blood residence.