公开(公告)号：EP2822539B1

公开(公告)日：2018-11-21

申请号：EP13724871.2

申请日：2013-03-07

申请人： National Institute Of Pharmaceutical Education And Research (NIPER)

发明人： BANSAL, Arvind, Kumar ,  DANTULURI, Ajay, Kumar, Raju ,  SHETE, Ganesh, Bhaskarao ,  PAWAR, Yogesh, Bapurao

IPC分类号： A61K9/16 ,  A61K31/192 ,  A61K31/198 ,  A61K31/216 ,  A61K31/405 ,  A61K31/415

CPC分类号： A61K31/415 ,  A23D7/0053 ,  A23L33/10 ,  A23L33/105 ,  A23L33/12 ,  A23L33/15 ,  A23L33/155 ,  A23L33/16 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1623 ,  A61K31/12 ,  A61K31/192 ,  A61K31/197 ,  A61K31/198 ,  A61K31/216 ,  A61K31/353 ,  A61K31/405 ,  A61K31/4184 ,  A61K31/496 ,  A61K31/635 ,  A23V2200/25 ,  A23V2250/1886 ,  A23V2250/2112

摘要： The present invention relates to a method of preparation of discrete particles of nanocrystalline solid dispersion, wherein said discrete particle comprises crystals of said active ingredient(s) in the matrix of the said crystallization inducer(s) and/or coexisting with crystals of crystallization inducer(s), optionally along with pharmaceutically acceptable excipient(s). An active ingredient and crystallization inducer is dissolved in a solvent or solvent mixture and then dried to obtain discrete particles of 0.5 to 20 micron size. Each particle consists of crystals of active ingredient in the range of 10-1000 nm dispersed in the matrix of crystallization inducer.