公开(公告)号：EP3872055A1

公开(公告)日：2021-09-01

申请号：EP19876774.1

申请日：2019-10-23

申请人： National University Corporation Hokkaido University

发明人： ITO, Hajime ,  KUBOTA, Koji

IPC分类号： C07C1/32 ,  C07C15/14 ,  C07C15/24 ,  C07C19/08 ,  C07C41/22 ,  C07C43/205 ,  C07C45/68 ,  C07C69/76 ,  C07C209/10 ,  C07C209/68 ,  C07C211/48 ,  C07C211/54 ,  C07C211/58 ,  C07C211/61 ,  C07D333/08 ,  C07D333/36 ,  C07F5/02 ,  C09B47/00 ,  C07C17/275 ,  C07C49/784 ,  C07B61/00

摘要： Disclosed is a cross-coupling reaction method which forms a chemical bond selected from C-N, C-B, C-C, C-O and C-S bonds, the method comprising:
preparing an aromatic compound (1) having a leaving group;
preparing a compound (2) capable of undergoing a cross-coupling reaction selected from an aromatic amino compound (2-1), a diboronic acid ester or the like (2-2), an aromatic boronic acid or the like (2-3), an aromatic compound (2-4) having a hydroxyl group and an aromatic compound (2-5) having a thiol group; and
performing a cross-coupling reaction of the compound (1) with the compound (2) in the presence of a palladium catalyst, a base and a compound (4) having a carbon-carbon double bond or a carbon-carbon triple bond, in the absence of a solvent.

公开(公告)号：EP4310067A1

公开(公告)日：2024-01-24

申请号：EP22771541.4

申请日：2022-03-18

申请人： National University Corporation Hokkaido University

发明人： ITO, Hajime ,  KUBOTA, Koji

IPC分类号： C07B49/00 ,  C07C29/40 ,  C07C33/20 ,  C07C33/24 ,  C07C33/34 ,  C07C33/50 ,  C07C45/00 ,  C07C45/61 ,  C07F3/02 ,  C07C49/11

摘要： A first object is to provide a method for producing an organometallic nucleophile, which uses a reduced amount of organic solvent to reduce environmental load and which does not require the adjustment of an atmosphere or water (moisture) and thus is a simplified means without the use of a large-scale apparatus. A second object is to provide a reaction method by which reactions between an organometallic nucleophile and various organic electrophiles can be performed by an efficient and simplified means such as a one-pot system and which is advantageous in terms of cost. A third object is to provide a simplified method for producing an organometallic nucleophile having higher reactivity. As a solution, a method for producing an organometallic nucleophile, including reacting an organohalide and a metal or metal compound with each other by a mechanochemical process in the presence of an ether compound in an amount of 0.5 to 10.0 equivalents relative to 1 equivalent of the organohalide, is provided.

公开(公告)号：EP4116282A1

公开(公告)日：2023-01-11

申请号：EP21764165.3

申请日：2021-03-02

申请人： National University Corporation Hokkaido University

发明人： ITO, Hajime ,  KUBOTA, Koji

IPC分类号： C07C1/32 ,  C07C15/20 ,  C07C25/22 ,  C07C41/30 ,  C07C43/205 ,  C07C209/68 ,  C07C211/45 ,  C07D333/16 ,  C07D333/18 ,  C07D333/56 ,  C07C17/26 ,  C07B61/00

摘要： Disclosed is a method for producing a mono-cross-coupled aromatic compound (3-1) having one less leaving group than an aromatic compound (1) having at least two leaving groups, the method comprising: preparing the aromatic compound (1) having at least two leaving groups; preparing a compound (2) capable of undergoing a cross-coupling reaction selected from an aromatic boronic acid (2-1), an aromatic amino compound (2-2), a diboronic acid ester (2-3), an aromatic compound (2-4) having a hydroxyl group and an aromatic compound (2-5) having a thiol group; and performing a cross-coupling reaction of the aromatic compound (1) having at least two leaving groups with the compound (2) in the presence of a palladium catalyst and a base, in the absence of a solvent.

公开(公告)号：EP4026821A1

公开(公告)日：2022-07-13

申请号：EP20861184.8

申请日：2020-09-04

申请人： National University Corporation Hokkaido University

发明人： ITO, Hajime ,  KUBOTA, Koji

IPC分类号： C07B37/04 ,  C07C41/30 ,  C07C43/225 ,  C07C201/12 ,  C07C205/06 ,  C07D333/10 ,  C07D333/38 ,  C07F5/02 ,  C07D209/42 ,  C07D307/06

摘要： Disclosed are a method for producing a highly reactive intermediate, which comprises: preparing an electron-accepting active compound (1), preparing a piezoelectric material (3), and applying mechanical strain to the piezoelectric material (3) in the presence of the electron-accepting active compound (1) and the piezoelectric material (3), and subjecting the compound (1) to one-electron reduction to generate a corresponding highly reactive intermediate; a redox reaction method using the method for producing the same; and a method for producing a redox reaction product.