公开(公告)号：EP2513087A1

公开(公告)日：2012-10-24

申请号：EP10796372.0

申请日：2010-12-16

申请人： NeuroSearch A/S

发明人： PETERS, Dan ,  GRUNNET, Morten ,  TIMMERMANN, Daniel, B. ,  ERIKSEN, Birgitte, L. ,  DYHRING, Tino ,  AHRING, Philip, K.

IPC分类号： C07D401/14 ,  A61K31/4439 ,  A61K31/41 ,  A61P5/00

CPC分类号： C07D401/14

摘要： This invention relates to novel tetrazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

公开(公告)号：EP2155700A1

公开(公告)日：2010-02-24

申请号：EP08736619.1

申请日：2008-04-29

申请人： NeuroSearch A/S

发明人： NARDI, Antonio ,  CHRISTENSEN, Jeppe, Kejser ,  GRUNNET, Morten ,  CHRISTOPHERSEN, Palle ,  JONES, David, Spencer ,  NIELSEN, Elsebet, Østergaard ,  STRØBÆK, Dorte ,  MADSEN, Lars, Siim

IPC分类号： C07D257/04 ,  A61K31/41 ,  A61P9/00

CPC分类号： C07D257/04

摘要： This invention relates to novel β-keto-amide derivatives that are found to be potent modulators of ion channels, and in particular potassium channels and chloride channels, and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.

摘要翻译： 本发明涉及新的β-酮酰胺衍生物，其被发现是有效的离子通道调节剂，特别是钾通道和氯离子通道，因此它们是治疗各种疾病或病症的有价值的候选者 它们响应于钾通道的调节。

公开(公告)号：EP2814473A1

公开(公告)日：2014-12-24

申请号：EP13703834.5

申请日：2013-02-14

申请人： NeuroSearch A/S

发明人： HANSEN, Henrik Björk ,  GRUNNET, Morten ,  BENTZEN, Bo Hjorth ,  HYVELED-NIELSEN, Lars ,  LASSEN, Jørgen Buus ,  SUNDGREEN, Claus

IPC分类号： A61K31/135 ,  A61K31/46 ,  A61P3/04 ,  A61P9/00 ,  A61P3/00 ,  A61P9/10 ,  A61P3/10

CPC分类号： A61K31/138 ,  A61K31/135 ,  A61K31/46 ,  A61K2300/00

摘要： This invention relates to the use of pharmaceutical compositions comprising a therapeutically effective combination of Tesofensine and Metoprolol for preventing the cardiovascular side effects of Tesofensine, while leaving the robust inhibitory efficacy on food intake and body weight loss unaffected.

公开(公告)号：EP2094655A1

公开(公告)日：2009-09-02

申请号：EP07857650.1

申请日：2007-12-17

申请人： NeuroSearch A/S

发明人： NARDI, Antonio ,  DEMNITZ, Joachim ,  GRUNNET, Morten ,  CHRISTOPHERSEN, Palle ,  JONES, David Spencer ,  NIELSEN, Elsebet Østergaard ,  STRØBÆK, Dorte ,  MADSEN, Lars Siim

IPC分类号： C07C335/18 ,  C07D257/04 ,  A61K31/17 ,  A61P15/12

CPC分类号： C07D257/04 ,  A61K31/17 ,  A61K31/41 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/53 ,  C07C335/18

摘要： The invention relates to novel biphenyl thio-urea derivatives of Formula (I), wherein A represents hydroxy or tetrazolyl; R1 represents halo, hydroxy or phenyl, which phenyl may optionally be substituted with halo; and R2 and R3, independent of each other, represent halo, trifluoromethyl, nitro and/or phenyl, that are found to be potent modulators of ion channels and, as such, they are valuable candidates for the treatment of disease or disorders as diverse as those which are responsive to modulation of ion channels.

公开(公告)号：EP1663192B1

公开(公告)日：2008-12-03

申请号：EP04766708.4

申请日：2004-09-06

申请人： NeuroSearch A/S

发明人： OLESEN, Soeren, Peter ,  GRUNNET, Morten ,  CHRISTOPHERSEN, Palle ,  STROBAEK, Dorte ,  DEMNITZ, Joachim ,  HANSEN, Rie, S.

IPC分类号： A61K31/17 ,  A61K31/41 ,  A61K31/00 ,  A61P9/06 ,  A61P9/10

CPC分类号： A61K31/00 ,  A61K31/17 ,  A61K31/41

摘要： This invention relates to the use of ERG channel openers for the treatment of cardiac arrhythmias, and to the use of specific compounds for such treatment. In a separate aspect the invention provides novel compounds useful as ERG channel openers.

公开(公告)号：EP2155700B1

公开(公告)日：2010-10-06

申请号：EP08736619.1

申请日：2008-04-29

申请人： NeuroSearch A/S

发明人： NARDI, Antonio ,  CHRISTENSEN, Jeppe, Kejser ,  GRUNNET, Morten ,  CHRISTOPHERSEN, Palle ,  JONES, David, Spencer ,  NIELSEN, Elsebet, Østergaard ,  STRØBÆK, Dorte ,  MADSEN, Lars, Siim

IPC分类号： C07D257/04 ,  A61K31/41 ,  A61P9/00

CPC分类号： C07D257/04

公开(公告)号：EP2139855A1

公开(公告)日：2010-01-06

申请号：EP08717796.0

申请日：2008-03-14

申请人： NeuroSearch A/S

发明人： NARDI, Antonio ,  GRUNNET, Morten ,  CHRISTOPHERSEN, Palle ,  JONES, David, Spencer ,  NIELSEN, Elsebet, Østergaard ,  STRØBÆK, Dorte ,  MADSEN, Lars, Siim

IPC分类号： C07D209/04 ,  A61K31/405

CPC分类号： A61K31/405 ,  C07D209/42

摘要： This invention relates to pharmaceutical compositions comprising phenylcarbamoyl-methyl-indole derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.

公开(公告)号：EP2125790A1

公开(公告)日：2009-12-02

申请号：EP08701549.1

申请日：2008-01-17

申请人： NeuroSearch A/S

发明人： NARDI, Antonio ,  GRUNNET, Morten ,  DEMNITZ, Joachim ,  CHRISTOPHERSEN, Palle ,  JONES, David, Spencer ,  NIELSEN, Elsebet, Østergaard ,  STRØBÆK, Dorte ,  MADSEN, Lars, Siim

IPC分类号： C07D403/10 ,  C07D413/10 ,  A61K31/4192 ,  A61P9/00

CPC分类号： C07D413/10 ,  C07D403/10

摘要： This invention relates to novel 1,4-and 1,5-diarylsubstituted 1,2,3-triazole derivatives that are found to be potent modulators of potassium channels and, as such, they are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to modulation of potassium channels.

公开(公告)号：EP2152677A1

公开(公告)日：2010-02-17

申请号：EP08749830.9

申请日：2008-04-29

申请人： NeuroSearch A/S

发明人： NARDI, Antonio ,  GRUNNET, Morten ,  CHRISTOPHERSEN, Palle ,  DEMNITZ, Joachim ,  JONES, David, Spencer ,  NIELSEN, Elsebet, Østergaard ,  STRØBÆK, Dorte ,  MADSEN, Lars, Siim

IPC分类号： C07D257/04 ,  C07D271/07 ,  A61K31/41 ,  A61K31/4245 ,  A61P9/00

CPC分类号： C07D257/04 ,  C07D271/07

摘要： This invention relates to novel acetamide derivatives that are found to be potent modulators of ion channels, in particular potassium channels and chloride channels, and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.

公开(公告)号：EP2146971A1

公开(公告)日：2010-01-27

申请号：EP08750148.2

申请日：2008-05-07

申请人： NeuroSearch A/S

发明人： NARDI, Antonio ,  DEMNITZ, Joachim ,  GRUNNET, Morten ,  CHRISTOPHERSEN, Palle ,  JONES, David, Spencer ,  NIELSEN, Elsebet, Østergaard ,  STRØBÆK, Dorte ,  MADSEN, Lars, Siim

IPC分类号： C07D257/04 ,  C07D403/10 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/41 ,  A61P11/00

CPC分类号： C07D257/04 ,  C07D403/10

摘要： This invention relates to novel benzamidine derivatives of formula (I) that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels. A stereoisomer or a mixture of its stereoisomers, or an N-oxide thereof, or a pharmaceutically-acceptable addition salt thereof, wherein B may be absent (i.e. no heterocyclic ring is formed); and when absent, the nitrogen next to B holds a hydrogen (i.e. 'NH'), and A represents NH2 or OH; or B may be present (i.e. forms part of a heterocyclic ring); and when present, B represents C=O or C=S; and A represents NH or O; and wherein the rest of variables are as specified in claim 1.