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公开(公告)号：EP3235537B1
公开(公告)日：2019-08-07
申请号：EP15869935.5
申请日：2015-12-14
发明人： YAMADA, Shinya , CHIYAMA, Masateru , AKITA, Kensaku , UENO, Takako , IDE, Yuko , NAGAI, Sachi , AKAO, Osanobu , ONO, Ichiro , TAKADA, Kanji
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2.发明公开MICRONEEDLE-ARRAY PRODUCTION DEVICE, MICRONEEDLE-ARRAY PRODUCTION METHOD, AND ARTICLE PROVIDED WITH MICRONEEDLE ARRAY 审中-公开微型阵列生产装置，微型阵列生产方法和提供微型阵列的物品
公开(公告)号：EP3235537A1
公开(公告)日：2017-10-25
申请号：EP15869935.5
申请日：2015-12-14
发明人： YAMADA, Shinya , CHIYAMA, Masateru , AKITA, Kensaku , UENO, Takako , IDE, Yuko , NAGAI, Sachi , AKAO, Osanobu , ONO, Ichiro , TAKADA, Kanji
CPC分类号： B29C39/24 , A61M37/00 , A61M37/0015 , A61M2037/0053 , B05B12/122 , B29C65/004 , B29L2031/7544 , B81B1/00
摘要： A product having a microneedle array is provided wherein the composition distribution has been adjusted with good accuracy. A droplet-delivery apparatus (10) of a microneedle-array manufacturing apparatus (1) is configured capable of delivering, to each recessed part, droplets of a raw-material liquid in a prescribed amount that is less than the capacity of the recessed part. An aligning apparatus (20) can align the relative position of the droplet-delivery apparatus (10) and a mold (80) such that the droplets from the droplet-delivery apparatus (10) are caused to land in each of the recessed parts. The droplet-delivery apparatus (10) delivers a plurality of the droplets to each of the recessed parts; and the aligning apparatus aligns the relative position of the droplet-delivery apparatus and the mold such that a second droplet lands in each of the recessed parts on the center part side of a first droplet.
摘要翻译： 提供了具有微针阵列的产品，其中组合物分布已经以良好的精度进行了调整。 微针阵列制造装置（1）的液滴输送装置（10）被构造成能够将小于凹部的容量的规定量的原料液的液滴输送到每个凹部 。 对准装置（20）可以使液滴输送装置（10）和模具（80）的相对位置对齐，使得来自液滴输送装置（10）的液滴落在每个凹陷部分中。 液滴输送装置（10）将多个液滴输送至每个凹陷部分; 并且对准装置将液滴输送设备和模具的相对位置对齐，使得第二液滴落在第一液滴的中心部分侧的每个凹陷部分中。
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3.发明公开MICRONEEDLE PATCH, METHOD FOR MANUFACTURING SAME, AND APPARATUS FOR MANUFACTURING MICRONEEDLE ARRAY 审中-公开MICRONEEDLE PATCH，其制造方法及用于制造MICRONEEDLE ARRAY的装置
公开(公告)号：EP3235538A1
公开(公告)日：2017-10-25
申请号：EP15869985.0
申请日：2015-12-15
发明人： ONO, Ichiro , YAMADA, Shinya , CHIYAMA, Masateru , AKITA, Kensaku , UENO, Takako , IDE, Yuko , NAGAI, Sachi , AKAO, Osanobu , TAKADA, Kanji
CPC分类号： B29C39/24 , A61M37/00 , A61M37/0015 , A61M2037/0053 , B05B12/122 , B29C65/004 , B29L2031/7544 , B81B1/00
摘要： A microneedle patch with which a treatment is reliably completed in a short time when a microneedle is administered into skin or mucous membrane is provided. A microneedle patch (100F) includes a base member (101) and a plurality of microneedles (103g) supported by the base member (101). Each microneedle (103g) includes a top-section layer (104) comprising a biologically active substance to be inserted in dermis (310), and an intermediate layer (106) provided between the top-section layer (104) and the base member (101), having a composition having breaking strength weaker than breaking strength of a composition of the top-section layer (104), and having a thickness of 5 µm and 100 µm inclusive.
摘要翻译： 本发明提供一种微针贴片，该微针贴片在向皮肤或粘膜给予微针时能够在短时间内可靠地完成治疗。 微针贴片（100F）包括基座构件（101）和由基座构件（101）支撑的多个微针（103g）。 每个微针103g包括包含待插入真皮310中的生物活性物质的顶层部分104以及设置在顶层部分104和基底部件103之间的中间层106。 101），其组成具有断裂强度弱于顶部层（104）的组成的断裂强度，并且具有5μm和100μm（包括端值）的厚度。
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公开(公告)号：EP3459584A1
公开(公告)日：2019-03-27
申请号：EP17806519.9
申请日：2017-05-25
申请人： Nissha Co., Ltd.
摘要： Provided is an inexpensive microneedle array with little dimensional error that can control, with high precision, the amount of a predetermined component to be introduced to the inner part of the skin, and a production method for this microneedle array. A foundation (14) that is insoluble or sparingly soluble in a raw material liquid (200) is overlaid on a mold (50). A plurality of frustum-shaped protrusions (14), which are insoluble or sparingly soluble in the raw material liquid (200), provided on a first main surface (14a) of the foundation (14) are fit into a plurality of cone-shaped recesses (51). The raw material liquid (200) in the plurality of cone-shaped recesses (51) dries and, as a result, a plurality of microneedles, which are dissolvable in the inner part of the skin, are fixed to tip surfaces of the plurality of frustum-shaped protrusions.
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